8,723 peptide studies,
read so you don't have to.

1. 2026-09-13 PubMed

   Oral Small-Molecule GLP-1 RAs Offer Enhanced Access and Adherence for Cardiometabolic Conditions

   Oral small-molecule GLP-1 receptor agonists, including orforglipron, promise improved accessibility and adherence for **type 2 diabetes** and **obesity** management.

2. 2026-09-13 PubMed

   GLP-1RA Discontinuation Leads to Significant Weight Regain; Tirzepatide Shows Higher Rebound Than Semaglutide

   Discontinuing **GLP-1RAs** causes significant weight regain (**MD = 17.90%**), with **tirzepatide** showing higher rebound than **semaglutide**.

3. 2026-09-13 PubMed

   GLP-1 Receptor Agonists Show No Bone Effect, Significantly Reduce Lean Body Mass in Meta-Analysis

   GLP-1 RAs showed no bone or fracture effect in a meta-analysis, but consistently reduced lean body mass by a standardized mean difference of **0.52**.

4. 2026-09-12 PubMed

   Structural Features Drive GLP-1 Analog Efficacy and Pharmacokinetics, Guiding Next-Gen Incretin Design

   This review consolidates knowledge crucial for designing more effective and longer-acting **GLP-1** analogs. **Understanding these structural principles allows for rational design of peptides with improved stability, receptor selectivity…

5. 2026-09-11 PubMed

   Semaglutide Therapy Linked to Acute Pancreatitis in 41-Year-Old Man for Weight Loss

   This case report underscores the importance of clinician awareness regarding the rare but serious risk of **acute pancreatitis** associated with **semaglutide**, especially when prescribed for weight loss in non-diabetic individuals. For…

6. 2012-06-18 ClinicalTrials.gov

   Cixutumumab and temsirolimus combination therapy evaluated for recurrent or refractory sarcoma in younger patients

   While specific results are not detailed in this abstract, the investigation of **cixutumumab** and **temsirolimus** for recurrent sarcoma represents a crucial step towards targeted therapies for a devastating disease. **If successful, th…

7. 2019-06-18 ClinicalTrials.gov

   Acromegaly Study Aims to Quantify Therapy Effects on Hand/Foot Dimensions and Gait via 3D Scanning

   While this abstract presents no results, the study's aims highlight a critical need to **quantify the impact of acromegaly therapies on physical manifestations beyond just hormonal levels**. Current treatment success is often gauged by G…

8. 2026-01-01 ClinicalTrials.gov

   Randomized trial to evaluate combined nipple stimulation and Foley balloon for improved cervical ripening

   If successful, this trial could **integrate a physiological, low-cost intervention into standard labor induction protocols**, potentially reducing the reliance on pharmacological agents or more invasive procedures. For clinicians, a vali…

9. 2022-10-29 ClinicalTrials.gov

   Chronic Dry Eye Post-LASIK: Ocular Surface, Cytokine, and Neuropeptide Profiles Under Investigation

   Understanding the distinct clinical characteristics, **cytokine** profiles, and **neuropeptide** changes in chronic dry eye patients post-LASIK, especially those with persistent pain, could significantly refine diagnostic approaches and …

10. 2026-09-11 ClinicalTrials.gov

    Intranasal Oxytocin (TI-001) Trial Investigates High Frequency Episodic and Chronic Migraine

    A randomized clinical trial evaluated intranasal oxytocin (TI-001) for treating high frequency episodic and chronic migraine.

11. 2023-07-12 ClinicalTrials.gov

    Tranexamic Acid's Efficacy for Postpartum Hemorrhage in Placenta Previa Patients Remains Unclear

    Existing evidence on tranexamic acid's prophylactic use for **postpartum hemorrhage** in high-risk **placenta previa** patients is inconclusive due to poor study quality and insufficient power.

12. 2026-09-11 ClinicalTrials.gov

    Oxytocin blunts LPS-induced cytokine and endocrine responses in healthy human volunteers

    If oxytocin effectively blunts **LPS**-induced inflammation and modulates endocrine responses, it could open new avenues for treating acute and chronic inflammatory conditions. **This research could position oxytocin as a novel therapeut…

13. 2021-09-01 ClinicalTrials.gov

    Intensive glucose management strategy aims to preserve β-cell function and reduce complications in Type 2 Diabetes

    If successful, the "CHANGE" study could fundamentally shift the paradigm for **Type 2 Diabetes** management from reactive treatment to proactive disease modification. **Preserving β-cell function** would mean fewer patients progressing t…

14. 2024-10-24 ClinicalTrials.gov

    Semaglutide's SUSTAIN6 Trial Outcomes Emulated Using Healthcare Claims Data to Assess Real-World Evidence Validity

    A study is emulating the **semaglutide** SUSTAIN6 trial using healthcare claims data to validate real-world evidence methods for clinical questions.

15. 2026-09-11 PubMed

    Proline-regulated G5P2 antimicrobial peptide achieves 93.52% bacterial clearance in vivo, synergizes with antibiotics

    This study offers a novel and efficient strategy for designing highly selective antimicrobial peptides, addressing a critical gap in combating **drug-resistant bacterial infections**. The optimized peptide, **G5P2**, represents a compell…

16. 2026-09-11 PubMed

    Ixekizumab and Upadacitinib Combination Resolves Refractory Psoriatic Arthritis Symptoms in a 35-Year-Old Male

    **Ixekizumab** (IL-17 inhibitor) and **upadacitinib** (JAK inhibitor) combination resolved refractory psoriatic arthritis symptoms and normalized inflammatory markers in a 35-year-old male.

17. 2026-09-11 PubMed

    Platelet-rich plasma, autologous serum, and cyclosporine A improve Sjögren's dry eye outcomes

    Platelet-rich plasma, autologous serum, and cyclosporine A topical therapies show outcome-specific benefits for Sjögren's dry eye, improving ocular staining, tear stability, and secretion.

18. 2026-09-11 PubMed

    SFRP2 Potentiates Colon Cancer Metastasis by Stabilizing Snai1 Protein via USP11

    SFRP2 enhances colon cancer cell migration and invasion by stabilizing the Snai1 protein through USP11, forming a feedback loop that drives metastasis.

19. 2026-09-11 PubMed

    Mignot and Yanagisawa Awarded Lasker Prize for Orexin Discovery in Wake, Sleep, and Narcolepsy

    Emmanuel Mignot and Masashi Yanagisawa received the Lasker Prize for their independent discoveries of orexin's fundamental role in regulating wakefulness, sleep, and its link to narcolepsy.

20. 2026-09-11 PubMed

    Orexin Deficiency Identified as Core Cause of Narcolepsy via Dual Genetic Approaches

    This seminal work fundamentally transformed the understanding of **sleep-wake regulation** and the etiology of narcolepsy, moving beyond symptomatic treatments to address the root cause. **The identification of orexin as the key neuropep…

21. 2026-09-11 PubMed

    CRBN-based PROTAC CW-10201 degrades KRAS G12D/G12V mutants, inducing tumor regression in xenograft models.

    The discovery of **CW-10201** represents a significant advance in targeting **KRAS G12D** and **G12V** mutations, which are notoriously challenging and drive a large proportion of human cancers. **This PROTAC approach offers a distinct a…

22. 2015-03-20 ClinicalTrials.gov

    Oxytocin's impact on approach/avoidance behaviors in complicated grief explored in randomized trial

    If future results from this study demonstrate a significant effect, **intranasal oxytocin** could emerge as a novel therapeutic target for modulating maladaptive approach/avoidance behaviors in **complicated grief**. This could lead to n…

23. 2022-02-03 ClinicalTrials.gov

    Sogroya (Somapacitan) long-term safety and effectiveness assessed in Japanese adults with severe AGHD

    This post-marketing surveillance study is critical for understanding the real-world profile of **Sogroya (somapacitan)**, particularly its long-term safety and effectiveness in a diverse patient population outside of controlled clinical …

24. 2022-03-10 ClinicalTrials.gov

    Liraglutide's Effect on Weight Loss Investigated in Patients Post-Revisional Bariatric Surgery

    Addressing insufficient weight loss after **bariatric surgery** is a significant clinical challenge, impacting patient health and quality of life. If Liraglutide proves effective in this population, it could offer a crucial **non-surgica…

25. 2026-09-11 ClinicalTrials.gov

    Liraglutide plus metformin combination *investigated* for superior weight reduction in obese **PCOS** patients

    **Obese PCOS** patients who exhibit poor weight loss responses to metformin represent a significant clinical challenge. If the study's hypothesis is confirmed by its full results, **liraglutide** as an add-on to metformin could establish…

26. 2026-10-01 ClinicalTrials.gov

    Real-world study initiated for Tirzepatide outcomes in Pakistani adults with obesity, prediabetes, and type 2 diabetes

    This study is critical for providing the first real-world evidence of **Tirzepatide**'s performance in a **Pakistani** population, offering insights directly applicable to clinical practice in **South Asia**. **Clinicians will gain valua…

27. 2026-09-11 PubMed

    Adjunctive GLP-1RAs cut HbA1c **0.23%** and body weight **3.93 kg** in **Type 1 Diabetes**.

    Adjunctive GLP-1RAs reduced HbA1c by **0.23%** and body weight by **3.93 kg** in **Type 1 Diabetes** patients receiving insulin.

28. 2026-09-10 EuropePMC

    Molecular Synergy of SGLT2 Inhibitors and GLP-1R Agonists Targets Atrial Cardio-Metabolic Inflammation

    Review highlights how SGLT2 inhibitors and GLP-1 receptor agonists synergistically combat atrial cardio-metabolic cardiomyopathy by reducing inflammation and oxidative stress.

29. 2026-09-10 EuropePMC

    GLP-1 Receptor Agonist Weight Loss Surveyed for Dermatological, Trichological, and Quality of Life Consequences

    Understanding the dermatological and trichological consequences of **GLP-1 RA**-mediated weight loss is crucial for both clinicians and patients. **This research highlights the need for comprehensive patient counseling regarding potentia…

30. 2026-09-10 EuropePMC

    Prospective clinical trial evaluates GHK-conjugated spicule regimen with glutathione booster for aesthetic benefits

    A prospective, active-controlled split-face clinical trial is evaluating the incremental aesthetic benefits of a **glutathione**-containing booster in a **GHK**-conjugated spicule regimen.

31. 2026-09-10 PubMed

    Review highlights sex-specific differences in pancreatic α-cell function and glucagon secretion

    Understanding these **sex-specific differences in glucagon biology** is crucial for developing more precise and effective therapeutic strategies for metabolic diseases. Current treatments for conditions like **type 2 diabetes** often do …

32. 2026-09-10 PubMed

    Oral Semaglutide in EVOKE/EVOKE+ Trials Missed Alzheimer's Primary Endpoints; Reanalysis Shows Limited Inferential Weight

    **Clinicians and individuals considering GLP-1 receptor agonists for Alzheimer's disease should temper expectations regarding direct disease modification based on the EVOKE trials.** While the broader cardiometabolic hypothesis linking *…

33. 2026-09-10 ClinicalTrials.gov

    rhIGF-I/IGFBP-3 therapy evaluated for safety and growth velocity in children with Growth Hormone Insensitivity Syndrome

    **Successful rhIGF-I/IGFBP-3 therapy could offer a crucial treatment option for children with GHIS**, a condition currently lacking effective growth-promoting interventions. For clinicians, this therapy represents a direct approach to by…

34. 2016-06-15 ClinicalTrials.gov

    Intranasal Oxytocin + Social Skills Group Therapy Explored for Autism Spectrum Disorder

    If positive results are found, this study could significantly advance the treatment paradigm for **autism spectrum disorder (ASD)**, particularly in improving social cognitive skills. **Intranasal oxytocin**, if proven effective and safe…

35. 2026-09-10 ClinicalTrials.gov

    Vaginally administered Oxytocin investigated to reverse postmenopausal vaginal atrophy by promoting mucosal cell proliferation

    Should this study demonstrate positive results, it could offer a **novel, non-estrogen-based treatment option for postmenopausal vaginal atrophy**, potentially benefiting women who cannot or prefer not to use estrogen therapy. A topical …

36. 2026-09-10 ClinicalTrials.gov

    Trial to Assess Insulin Detemir's Effect in Combination with Liraglutide and Metformin for Type 2 Diabetes

    Understanding the optimal combination of established therapies is paramount for managing progressive **Type 2 Diabetes**. If this trial were to demonstrate superior efficacy for the triple combination of **insulin detemir**, **liraglutid…

37. 2026-09-10 ClinicalTrials.gov

    Liraglutide's Impact on Endothelial Function in Type 2 Diabetes Patients to be Investigated in US Trial

    A US-based randomized trial will assess liraglutide's effect on forearm blood flow in Type 2 Diabetes subjects on diet or metformin monotherapy.

38. 2011-05-23 ClinicalTrials.gov

    IDegLira combination therapy for Type 2 Diabetes compared against Liraglutide and Insulin Degludec monotherapies in global Phase 3 trial

    This trial is crucial for understanding the comparative benefits of **IDegLira** as a fixed-ratio combination therapy for **Type 2 Diabetes**. If the combination proves superior in efficacy or safety compared to its individual components…

39. 2025-08-01 ClinicalTrials.gov

    Generic semaglutide injection vs. Ozempic® efficacy and safety evaluated in Phase III Type 2 Diabetes trial

    The successful completion of this Phase III trial, demonstrating equivalence between a generic semaglutide injection and branded Ozempic®, could significantly impact **Type 2 Diabetes** treatment accessibility. **Increased availability o…

40. 2026-07-15 ClinicalTrials.gov

    Semaglutide study to image muscle volume, quality, and metabolic function in T2D and obesity

    **Understanding semaglutide's impact on muscle health is critical for optimizing patient care, especially during significant weight loss.** If semaglutide can preserve or even improve muscle quality and function, it could mitigate concer…

41. 2025-09-11 ClinicalTrials.gov

    Semaglutide to be investigated for improving depressive symptoms in MDD patients with overweight or obesity

    If the trial demonstrates positive results, **semaglutide could become a valuable adjunctive treatment for MDD patients with co-occurring overweight or obesity**, offering a dual benefit for both metabolic health and mood. This would pro…

42. 2025-11-10 ClinicalTrials.gov

    Wegovy's Real-World Effectiveness and Safety in Korean Patients with Obesity to be Assessed Over 52 Weeks

    Wegovy (semaglutide) effectiveness and safety for obesity in Korean patients will be investigated in a 52-week real-world study, focusing on weight change and clinical characteristics.

43. 2026-08-01 ClinicalTrials.gov

    Tirzepatide Pilot Trial to Assess Feasibility and Tolerability for Cannabis Use Disorder Treatment

    Proposed Phase 2 trial to evaluate feasibility and tolerability of weekly **Tirzepatide** injections for adults with **Cannabis Use Disorder** (CUD).

44. 2026-09-09 PubMed

    Semaglutide and Tirzepatide Linked to Reduced Skin Cancer Risk in Obese Patients

    Obese patients on semaglutide and tirzepatide showed a reduced risk of melanoma and nonmelanoma skin cancers in a real-world observational study.

45. 2026-09-09 PubMed

    Thymosin-ɑ1 Meta-Analysis Aims to Clarify Benefits, Harms for Chronic Hepatitis B

    A Cochrane meta-analysis aims to systematically assess the benefits and harms of **Thymosin-ɑ1** therapy for people with chronic hepatitis B, addressing prior inconsistent findings.

46. 2022-02-18 ClinicalTrials.gov

    Oral LUM-201 Growth Response Explored in Children with Prior rhGH-Treated GHD

    **An effective oral treatment for growth hormone deficiency could significantly improve patient adherence and quality of life** for children and their families. The burden of daily injections is a major factor in treatment discontinuatio…

47. 2026-09-09 ClinicalTrials.gov

    rhIGF-1 Treatment Aims to Increase Height Velocity in Children with IGF-1 Deficiency

    A Phase 3 trial investigates **rhIGF-1** once daily dosing to increase height velocity in prepubertal children with primary `IGF-1` deficiency.

48. 2026-09-09 ClinicalTrials.gov

    Intranasal Oxytocin Study Aims to Evaluate Effects on Human Pain Sensitivity and Threshold

    A study hypothesized intranasal oxytocin would decrease pain sensitivity and increase pain threshold in human volunteers compared to saline.

49. 2026-09-01 ClinicalTrials.gov

    Mazdutide Trial Investigates Portal Pressure Reduction in Overweight Compensated Cirrhosis Patients with CSPH

    If successful, this trial could establish **Mazdutide** as a novel pharmacological strategy for reducing portal hypertension in patients with **compensated cirrhosis** and **obesity/MASLD**, a population with limited treatment options. *…

50. 2026-02-01 ClinicalTrials.gov

    Semaglutide's Effects and Mechanisms on Intestinal Flora in Obese Patients Clarified by Multi-Omics

    Semaglutide treatment's effects and specific mechanisms on the intestinal flora of obese patients were clarified using multi-omics techniques and in vitro strain screening.

51. 2019-07-24 ClinicalTrials.gov

    Semaglutide Clinical Trial Protocol to Map Hepatic Glucose Response in Non-Alcoholic Fatty Liver Disease

    This detailed protocol for the NAFLD HEROES trial is significant because it outlines a robust investigation into **semaglutide's** potential role in managing **NAFLD** by understanding its impact on hepatic glucose response. For peptide …

52. 2026-09-09 PubMed

    GLP-1 Receptor Agonists Offer Transformative Therapeutic Opportunity for Polyendocrine Metabolic Ovarian Syndrome

    **GLP-1 receptor agonists (GLP-1RAs) are poised to transform the management of polyendocrine metabolic ovarian syndrome (PMOS)**, offering a unified approach to a condition historically managed with fragmented therapies. For clinicians, …

53. 2026-09-08 PubMed

    Salivary **cathelicidin LL-37** levels rise progressively, detecting **oral squamous cell carcinoma** with high sensitivity.

    This research offers a significant step towards a non-invasive, early detection method for **oral squamous cell carcinoma (OSCC)**, potentially transforming current diagnostic protocols. **Salivary LL-37 could enable routine screening fo…

54. 2026-09-08 ClinicalTrials.gov

    High Protein Diet's Effects on Older Women's Gut Microbiota, GI Function, and Wellness to be Determined

    A proposed study aims to determine how a high protein diet impacts fecal microbiota, GI function, and overall wellness in older women.

55. 2026-09-08 ClinicalTrials.gov

    Oxytocin with membrane sweeping compared against dinoprostone pessary for labor induction in term multiparas

    While specific results are not available, understanding the comparative efficacy of **oxytocin with membrane sweeping** versus **dinoprostone pessary** could significantly impact obstetric practice. If one method proves superior in terms…

56. 2019-03-28 ClinicalTrials.gov

    Intravenous anesthetics' impact on human uterine contractility to be compared in vitro, informing postpartum hemorrhage prevention

    This study's findings will be pivotal for anesthesiologists, providing critical data to inform drug selection during cesarean sections, particularly for patients at high risk of **postpartum hemorrhage (PPH)**. **Understanding how intrav…

57. 2025-09-15 ClinicalTrials.gov

    Extracellular Calcium's Role in Carbetocin-Mediated Human Myometrial Contractility Hypothesized to Optimize Uterine Tone

    If the hypothesis is confirmed, this research could significantly refine **postpartum hemorrhage (PPH)** prevention and treatment protocols, particularly for women with comorbidities or labor arrest. **Optimizing carbetocin's efficacy by…

58. 2017-01-04 ClinicalTrials.gov

    Outpatient Foley catheter cervical ripening aims to reduce hospital time and costs for labor induction

    A randomized trial compares outpatient versus inpatient transcervical Foley catheter placement for labor induction, anticipating reduced hospitalization time and costs.

59. 2015-09-28 ClinicalTrials.gov

    High-dose vs. low-dose **oxytocin** regimens compared for labor augmentation, aiming to reduce C-section risk

    Optimizing **oxytocin** dosing for labor augmentation holds significant implications for maternal and neonatal health. If a higher-dose regimen is proven to safely reduce C-section rates without increasing adverse events, it could **stan…

60. 2026-09-08 PubMed

    Inflammation Emerges as Central Therapeutic Target for Chronic Kidney Disease and Cardiovascular Complications

    Inflammation is a critical therapeutic target for **chronic kidney disease (CKD)** and cardiovascular events. Existing therapies like **GLP-1 receptor agonists** also exert anti-inflammatory effects.

61. 2026-09-08 PubMed

    Gene-modified MSC-Exos show therapeutic potential for insulin resistance by targeting mitochondrial crosstalk and miRNA regulation

    This review underscores a significant shift in the approach to **insulin resistance** therapy, moving from symptomatic management to precision disease modification. For biohackers and clinicians, the concept of gene-modified MSC-Exos rep…

62. 2026-09-08 PubMed

    Multi-epitope peptide vaccine design against Nipah virus phosphoprotein shows robust immune potential

    **This *in-silico* design provides a crucial blueprint for developing a much-needed Nipah virus vaccine.** The identification of conserved multi-epitopes and the predicted robust immune response suggest a promising path towards a broadly…

63. 2026-09-08 PubMed

    Immunoinformatics-designed mRNA vaccine candidate against **Trypanosoma brucei** achieves **100% global population coverage** and robust in-silico immune responses.

    An in-silico designed mRNA vaccine candidate targeting **Trypanosoma brucei** demonstrated **100% global population coverage** and robust simulated humoral and cellular immune responses.

64. 2026-09-08 PubMed

    Age-dependent H3K27me3 accumulation represses Hippo-YAP signaling, driving chicken OSC decline.

    Age-dependent H3K27me3 accumulation epigenetically represses `Hippo-YAP` signaling, significantly reducing oogonial stem cell proliferation in aging chickens.

65. 2026-09-08 PubMed

    Non-surgical periodontal treatment reduces elevated GCF prolactin in periodontitis patients with type 2 diabetes.

    Non-surgical periodontal treatment reduced elevated GCF prolactin in periodontitis patients with type 2 diabetes, linking it to disease and suggesting a biomarker role.

66. 2026-09-08 PubMed

    Metformin plus insulin therapy reduces HbA1c and improves retinal microvascular density in type 2 diabetic retinopathy

    Combined metformin and insulin therapy significantly reduced HbA1c and improved retinal microvascular density in type 2 diabetic retinopathy patients over two years.

67. 2026-09-08 PubMed

    Hydrogen Sulfide Suppresses Osteoclast Differentiation via Nrf2/GPX4 Pathway in RAW264.7 Cells

    This study provides a crucial mechanistic understanding of how hydrogen sulfide (H2S) can inhibit osteoclast differentiation, highlighting the `Nrf2/GPX4` pathway as a key mediator. **For individuals concerned with bone health or bone-re…

68. 2026-09-08 PubMed

    SS31-functionalized nanovesicles ameliorate rheumatoid arthritis by regulating macrophage autophagy and cGAS-STING signaling

    Engineered SS31-CB@MM-FNVs/CLT nanovesicles target macrophage mitochondria, scavenging ROS, activating autophagy, and inhibiting `cGAS-STING` to ameliorate **rheumatoid arthritis** in vitro and in vivo.

69. 2025-02-08 ClinicalTrials.gov

    Intra-articular Human Growth Hormone Injections Explored for Knee Osteoarthritis Cartilage Regeneration and Symptom Relief

    A clinical trial investigates if intra-articular `human growth hormone` injections can stimulate cartilage growth, reduce pain, and improve mobility in **knee osteoarthritis**.

70. 2026-11-15 ClinicalTrials.gov

    Mazdutide Trial to Evaluate Efficacy in Reducing Fatty Pancreas in Overweight/Obese Patients

    **Mazdutide's potential to reduce fatty pancreas could offer a novel therapeutic avenue for metabolic dysfunction.** For individuals with **overweight or obesity**, who are at high risk for **type 2 diabetes** and **pancreatitis**, this …

71. 2026-09-08 ClinicalTrials.gov

    Liraglutide's short-term kidney effects in Type 2 Diabetes patients investigated for nephroprotection

    Liraglutide's short-term impact on kidney function and injury markers in Type 2 Diabetes patients is being investigated, hypothesizing nephroprotection.

72. 2026-09-08 ClinicalTrials.gov

    Tirzepatide's Impact on Gastric Emptying in Type 1 Diabetes with Overweight/Obesity Under Investigation

    If **tirzepatide** demonstrates a favorable impact on gastric emptying in **Type 1 Diabetes Mellitus** patients with overweight/obesity, it could represent a significant advancement in managing this challenging comorbidity. **Slowing gas…

73. 2024-11-14 ClinicalTrials.gov

    Study Initiated to Assess Feasibility of Online Recruitment for Semaglutide, Tirzepatide Users

    Successful online recruitment for studies involving anti-obesity medications like **semaglutide** and **tirzepatide** could significantly accelerate real-world evidence generation. **This approach could enable faster insights into long-t…

74. 2026-09-07 PubMed

    Recombinant human growth hormone therapy safely improved growth in a child with brachydactyly type C

    This case report offers a significant insight for clinicians and patients dealing with **brachydactyly-associated short stature**, particularly when endogenous growth hormone levels are normal. **It suggests that rhGH therapy may be bene…

75. 2026-09-07 PubMed

    TRT plus SLT most effectively boosts testosterone and erectile function in obese hypogonadal men.

    A network meta-analysis found **TRT plus SLT** significantly increased total testosterone and improved erectile function in obese men with functional hypogonadism.

76. 2026-09-07 PubMed

    Tirzepatide-based therapy improves multidomain metabolic health in active-duty service member

    This case report suggests that a comprehensive treatment approach, including **tirzepatide**, can achieve significant multidomain metabolic improvement in young active-duty service members. **This finding is crucial for military healthca…

77. 2026-09-06 PubMed

    Semaglutide and Tirzepatide Drive 15-20% Weight Loss, Offer Broad Cardiometabolic Benefits

    This review underscores a paradigm shift in **obesity management**, moving beyond mere weight loss to comprehensive cardiometabolic health improvement. For peptide users and clinicians, this means that agents like **semaglutide** and **t…

78. 2026-09-04 EuropePMC

    sFlt-1/PlGF ratio predicts adverse perinatal outcomes even in low-risk term pregnancies below diagnostic thresholds.

    This research could significantly expand the utility of the `sFlt-1/PlGF ratio` beyond its current diagnostic role in high-risk pregnancies. **Identifying subtle angiogenic imbalances in low-risk term pregnancies could enable earlier int…

79. 2026-09-04 EuropePMC

    Aerobic Exercise and Abdominal Massage Combination Improves Functional Constipation Symptoms in Randomized Controlled Study

    **Integrating non-pharmacological approaches like aerobic exercise and abdominal massage could offer a valuable, accessible, and low-risk strategy for managing functional constipation.** For individuals struggling with chronic FC, this c…

80. 2026-09-04 EuropePMC

    Acyl-Coenzyme A Binding Protein (ACBP) levels paradoxically increase post-bariatric surgery, questioning its obesity biomarker role.

    This finding necessitates a critical re-evaluation of ACBP's role in **obesity** and **metabolic dysfunction**. If ACBP levels rise post-bariatric surgery despite significant weight loss, its utility as a simple biomarker for obesity sev…

81. 2026-09-04 EuropePMC

    Topical Zinc/Taurine/Panthenol cream demonstrates skin acceptability in females with urinary incontinence

    Topical cream with zinc oxide, zinc gluconate, taurine, and panthenol assessed for skin acceptability in females with urinary incontinence.

82. 2026-09-04 EuropePMC

    Phase 2/3 study evaluates investigational anti-inflammatory biologic therapy for Inclusion Body Myositis

    The initiation of a **Phase 2/3 clinical trial** for **Inclusion Body Myositis** represents a significant step forward in addressing a disease with profound unmet needs. If successful, this investigational anti-inflammatory biologic ther…

83. 2026-09-04 EuropePMC

    Collagen Biostimulators Offer Mechanistic Insights into GLP-1 RA-Induced Facial Aging

    Rapid weight loss from GLP-1 RAs like semaglutide causes 'Ozempic Face.' This paper explores how collagen biostimulators might counteract dermal mechanotransduction collapse.

84. 2026-09-04 PubMed

    PD-L1 and BCL2 proteins ubiquitously expressed in colorectal carcinoma, suggesting prognostic biomarker roles

    Immunohistochemistry revealed ubiquitous expression of `PD-L1` and `BCL2` proteins in **60** colorectal carcinoma patients, highlighting their potential as prognostic biomarkers.

85. 2026-09-04 PubMed

    Cyclosporine and prednisone perioperative regimen prevents pyoderma gangrenosum recurrence after breast reconstruction.

    This case report offers a significant practical takeaway for clinicians and patients with a history of **pyoderma gangrenosum** (PG) who require further surgery. **Perioperative immunosuppression with cyclosporine and prednisone can be a…

86. 2026-09-04 PubMed

    IL-31 drives **atopic dermatitis** and **prurigo nodularis** itch; Nemolizumab targeting IL-31RA demonstrates efficacy.

    **Targeting IL-31RA with nemolizumab offers a highly effective, mechanism-specific treatment option for patients with severe, intractable itch in atopic dermatitis and prurigo nodularis.** This review solidifies IL-31's central role in t…

87. 2026-09-04 PubMed

    mRNA-delivered Alb-IL-2var variant prolongs exposure, boosts CD8+ T cells, and enhances antitumor immunity

    An mRNA-delivered, albumin-fused IL-2 variant (Alb-IL-2var) with tuned CD25/CD122 affinity selectively expands CD8+ T cells and potentiates antitumor immunity.

88. 2026-09-04 PubMed

    Designer peptide CmTx potently blocks Kv1.5 channels by neutralizing R487 arginines, revealing electrostatic complementation

    **Overcoming Kv1.5's inherent resistance to peptide toxins, this work offers a novel strategy for drug development.** `CmTx` provides a valuable research tool to dissect `Kv1.5` channel physiology, particularly its role in conditions lik…

89. 2026-09-04 PubMed

    Tissue mitochondrial activity dictates macrophage pool size by modulating CSF1 availability, ensuring efficient waste disposal.

    **Understanding how tissue mitochondrial activity regulates macrophage populations opens new avenues for maintaining metabolic health and improving tissue repair.** This mechanism, where `CSF1` signaling links mitochondrial waste product…

90. 2026-09-04 PubMed

    Tirzepatide's emerging oral health implications demand focused attention in oral medicine practice

    **Oral medicine practitioners must proactively assess and manage potential oral health changes in patients using tirzepatide, integrating this knowledge into routine clinical practice.** This review signals a pressing need for updated cl…

91. 2025-04-15 ClinicalTrials.gov

    IBI311 IGF-1R Antibody to Evaluate Efficacy, Safety in Inactive Moderate-to-Severe Thyroid Eye Disease

    A clinical study will evaluate the efficacy and safety of **IBI311**, a fully human IGF-1R inhibitory antibody, for treating inactive moderate-to-severe thyroid-associated ophthalmopathy (TAO).

92. 2026-09-04 ClinicalTrials.gov

    Multicentric Cross-Sectional Study Initiated to Characterize Hypersomnia in Pediatric Populations

    A 36-month multicentric cross-sectional study is underway to characterize hypersomnia in children aged 6-17 across general, sleep disorder, and healthy populations.

93. 2023-05-25 ClinicalTrials.gov

    Carbetocin's effect on QT/QTc interval to be evaluated in healthy subjects for cardiac safety

    A trial will assess **Carbetocin's** impact on the QT/QTc interval in healthy individuals to ensure cardiac safety, as required by regulators.

94. 2019-01-01 ClinicalTrials.gov

    Oxytocin administration prior to planned C-section aims to reduce neonatal respiratory morbidity and improve bonding

    If successful, this study could introduce a significant **protocol change for planned caesarean sections**, potentially improving neonatal outcomes and early maternal-infant dynamics. For clinicians, implementing a pre-C-section **oxytoc…

95. 2021-06-24 ClinicalTrials.gov

    HIIT and MICT exercise protocols compared for maternal and child health during pregnancy

    Understanding the differential impacts of **HIIT** versus **MICT** during pregnancy could significantly refine exercise recommendations for expectant mothers and postpartum women. If HIIT proves superior for certain biological and psycho…

96. 2026-09-04 ClinicalTrials.gov

    Oxytocin, ACTH, and Cortisol Associations with Postpartum Mood and Lactation in Latinas to be Examined in New Study

    Understanding the interplay of **oxytocin**, **ACTH**, and **cortisol** with stress, trauma, **PPD**, and lactation in Latinas could revolutionize targeted support strategies. **Identifying distinct hormonal profiles or risk factors in i…

97. 2026-09-04 ClinicalTrials.gov

    Trauma exposure study aims to characterize social olfactory and tactile stimulus perception.

    Understanding how trauma exposure influences the perception of social olfactory and tactile stimuli is critical for advancing **PTSD** diagnostics and treatment. **Identifying specific sensory processing differences could lead to novel b…

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