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2026-10-28 PubMed

Plecanatide 3 mg dose offers optimal balance for chronic constipation and IBS-C, boosting bowel movements

Gut relief revisited: plecanatide in chronic idiopathic constipation and irritable bowel syndrome with constipation - a systematic review and meta-analysis with GRADE assessment.

Abstract

Plecanatide significantly increased complete spontaneous bowel movements (CSBMs) across all doses in chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C), with the 3 mg dose demonstrating the best efficacy-safety balance.


Source: pubmed:42934540 · Ingested Oct 28, 2026 · Digest: gemini-2.5-flash