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P21 2026-10-28 PubMed

Paeonol attenuates UVB-induced premature senescence in human dermal fibroblasts, reducing ROS, p16/p21, MMP-1, and SASP.

Paeonol Attenuates UVB-Induced Premature Senescence in Human Dermal Fibroblasts to Promote Skin Longevity.

Abstract

Paeonol reduced UVB-induced premature senescence in human dermal fibroblasts, decreasing SA-β-gal, ROS, p16/p21, MMP-1, and SASP factors, suggesting skin longevity benefits.


Source: pubmed:42942117 · Ingested Oct 28, 2026 · Digest: gemini-2.5-flash