106 studies on IGF-1 curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
Bottom line: TitrateLab currently tracks 17 published third-party lab tests of IGF-1 across 10 identified manufacturers. Among reports with a positive numeric purity result, the average is 99.17%. Within this published corpus, 0 positive purity results were below 90%, and 0 reports showed measured quantity more than 10% below the label claim. These are batch-level observations, not guarantees of product identity, safety, or vendor quality.
Independent certificate-of-analysis evidence from third-party labs — the data behind the studies. Updated as new COAs are verified. Read the full grey-market analysis →
Within that total, 6 batches have unresolved manufacturer identity. They remain in corpus-level lab evidence and are excluded from named-manufacturer rankings.
Recent certificates: #86142 (99.81%) · #15360 (98.134%) · #20106 (98.134%) · #95781 (98.587%) · #23248 (99.456%) · #23216 (99.563%)
Understanding the local pharmacokinetics of IGF-I in muscle tissue is critical for optimizing therapeutic strategies for Type 1 Diabetes Mellitus. If the microdialysis technique proves reliable for measuring interstit…
The continuation of similar monitoring efforts, as seen in the ongoing Increlex® Global Registry (NCT00903110), underscores the importance of continuous post-market surveillance for this patient population.
If the study demonstrates positive results, it could establish recombinant human growth hormone (rhGH) as a critical and effective treatment for short stature in children with chronic kidney disease prior to transplan…
This study is significant because it could elucidate the precise role of IGF-1 in the pathogenesis of vitiligo, specifically its interaction with oxidative stress. Understanding this mechanism could open new avenues f…
Despite its termination, this study highlights the ongoing effort to understand and optimize treatments for Primary IGF-1 Deficiency, a condition causing significant growth failure in children. The intent was to gathe…
While the specific, detailed results from this completed Phase 2 clinical trial (NCT01777542) are not included in the provided record, the study's primary objective was to evaluate the efficacy and safety of recombina…
This Phase 2 trial represents a significant step in exploring targeted treatments for Phelan-McDermid Syndrome, a condition with limited therapeutic options. If IGF-1 proves safe and effective in subsequent studies, i…
The development of a sustained-release human growth hormone (SR-hGH) formulation could significantly improve treatment adherence and quality of life for children with Idiopathic Short Stature (ISS) by reducing injecti…
The successful completion of this Phase 1 trial is a crucial step towards providing a more convenient treatment option for children with Growth Hormone Deficiency. A long-acting growth hormone like somapacitan could s…
If successful, this trial could establish **dietary interventions as a valuable adjunctive strategy for managing acromegaly**, potentially improving hormonal control and patient quality of life beyond current pharmaco…
This systematic review provides a comprehensive synthesis of the endocrine pathways connecting birth size to infant metabolic programming, highlighting the crucial roles of placental hormones and IGF-1. Understanding …
The termination of this trial highlights the significant challenges in developing and testing combination therapies for complex conditions like IGF-1 deficiency and short stature. While this specific study did not yie…
Sandostatin LAR is a well-established treatment for acromegaly, and this study aimed to refine our understanding of its comprehensive benefits beyond just hormone suppression. Demonstrating clear improvements in metab…
This study is significant because it explores the practical application of lanreotide Autogel 120 mg at extended dosing intervals, potentially offering a more convenient and less burdensome treatment schedule for pati…
The successful completion of this Phase 3 trial is a significant step towards developing an effective treatment for primary IGF-1 deficiency, a condition with limited therapeutic options. rhIGF-1 (mecasermin) holds su…
This pioneering single-patient study represents an early, crucial exploration into a novel therapeutic approach for a complex and rare genetic disease. Targeting low IGF-1 levels in Werner's Syndrome patients with ost…
This comprehensive review validates the traditional uses of velvet antler with a robust body of modern scientific evidence, establishing a strong foundation for its continued investigation as a potent therapeutic agen…
This research highlights that serum IGF-1 could serve as a valuable biomarker for predicting the progression of anxiety in Parkinson's disease patients, potentially allowing for earlier intervention. Identifying patie…
This research highlights Kisspeptin's potential as a therapeutic agent for mitigating the adverse effects of maternal hypothyroidism on pregnancy outcomes. The restoration of placental mTOR signaling and glucose homeo…
This research establishes IGF-1 deficiency as a crucial, previously underappreciated factor in the pathogenesis and prediction of Poor Ovarian Response. The findings suggest that routine screening for IGF-1 levels cou…
This study underscores the significant impact of modifiable lifestyle factors on IGF-1 levels and subsequent breast cancer risk, particularly within vulnerable populations like Palestinian women in the Gaza Strip. The…
This research identifies MLPH as a novel and potent regulator of human hair growth, acting directly on the critical IGF-1 signaling pathway within the dermal papilla. Understanding this mechanism provides a new therap…
This synthesis of evidence underscores the critical role of growth hormone (GH) in driving breast cancer progression, metastasis, and angiogenesis, moving beyond the traditional focus on steroid hormones. Understandin…
This research highlights a critical, previously underappreciated mechanism by which androgenic anabolic steroid (AAS) use may exert its adverse health effects. The disruption of the IGF-PAPP-A-stanniocalcin axis could…
This study represents a significant advancement in standardizing IGF-1 measurement, which is absolutely critical for accurate diagnosis and effective monitoring of endocrine disorders. The enhanced precision, accuracy…
This comprehensive review highlights the critical role of IGF-1 in MASLD pathogenesis, suggesting it's not just a correlative factor but potentially a key player. The most significant implication is that IGF-1 levels …
This study provides compelling evidence that combining BoNT-A with CIMT offers a synergistic approach to not only improve motor function but also actively promote skeletal muscle regeneration in hemiplegic cerebral pa…
This research suggests that tripeptide-copper complex could be a potent new agent for treating hair loss by directly stimulating hair follicle cells and upregulating critical growth factors. Its ability to promote cel…
This research fundamentally shifts our understanding of IGF-1's role in aging, proposing a biphasic model that moves beyond simple 'more is better' or 'less is better' paradigms. The identification of an IGF-1 senesce…
The establishment of accurate normative ranges for IGF-1, IGFBP-3, and ALS is profoundly important for pediatric endocrinology. These reference values provide clinicians with the necessary tools to differentiate betwe…
This global registry represents a crucial step in understanding the long-term safety and effectiveness of Increlex® for SPIGFD. By collecting data from a large, diverse patient population over many years, it can ident…
This research provides compelling evidence that recombinant IGF-1 can induce targeted organ growth, rather than generalized, uncontrolled proliferation, in a developing fetus. This specificity is critical, as it sugge…
This research provides compelling evidence that GH and IGF-I can effectively counteract the decline in milk production during prolonged lactation, suggesting new avenues for intervention. The distinct yet complementar…
This research provides critical insights into the intricate mechanisms governing coordinated cardiac and vascular development, particularly during vulnerable fetal stages. Understanding how IGF-1 orchestrates this bal…
This research provides compelling evidence that sustained elevated IGF-1 during fetal development directly programs pancreatic beta-cell dysfunction, leading to reduced glucose-stimulated insulin secretion. This is a …
This research highlights the fundamental importance of N-linked glycosylation for optimal IGF-1 signaling, providing crucial insights into cell biology and receptor function. Given that CHO cells are the primary indus…
This research highlights a complex interplay between IGF-1 and fetal glucose metabolism, suggesting that the in vivo effects of IGF-1 LR3 on insulin secretion are not solely due to direct actions on pancreatic beta ce…
This research highlights a critical insight into Alzheimer's disease pathology, suggesting that interventions solely focused on modifying amyloid plaques may not always translate into tangible cognitive benefits. The …
This study suggests that IGF-1 LR3 may not be an effective therapeutic strategy for reversing late-gestation intrauterine growth restriction (IUGR), even when systemic levels of IGF-1 are significantly elevated. The f…
This research introduces a highly innovative, sustainable, and biologically active nerve conduit derived from a plant source, offering a compelling alternative to current nerve repair strategies. The successful integr…
This research highlights a highly promising therapeutic strategy for treating volumetric muscle loss, a condition with limited effective treatments. By demonstrating that localized and sustained delivery of IGF-1 via …
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