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2026-10-26 PubMed

Tiplaxtinin inhibits SERPINE1 to suppress circEPSTI1 and reduce dengue virus replication

circEPSTI1 regulates miR-942-5p-SERPINE1-AKT1 signaling axis to enhance dengue infection and is suppressed by Tiplaxtinin.

Abstract

Tiplaxtinin inhibits SERPINE1, reducing circEPSTI1 expression and suppressing dengue virus replication by targeting the circEPSTI1-miR-942-5p-SERPINE1-AKT1 axis.


Source: pubmed:42932652 · Ingested Oct 26, 2026 · Digest: gemini-2.5-flash