S-ketoprofen stereoselectively interacts with L/D-Trp-Leu-Pro-Phe peptide, influencing aggregation and phototoxicity.
Stereoselectivity of photoinduced interaction of nonsteroidal anti-inflammatory drug S-ketoprofen with (L/D)-Trp-Leu-Pro-Phe peptide in solution studied by NMR, CIDNP and molecular dynamics simulation.
Abstract
(S)-ketoprofen demonstrates stereoselective interaction with L- and D-enantiomers of the WLPF tetrapeptide, with the D-epimer showing greater aggregation.
