54 studies on Oxytocin curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
A preliminary study assessed the feasibility and safety of intranasal oxytocin as an adjuvant treatment for challenging behaviors in children with autism spectrum disorder and moderate to severe intellectual disability.
If oxytocin is shown to enhance social cognition training outcomes in schizophrenia, it could represent a significant advance in treating a debilitating aspect of the disorder that current therapies often miss. For cl…
If this Phase 2 trial demonstrates positive results, it could establish intranasal oxytocin as a viable intervention for mitigating chronic stress in dementia caregivers. This would offer a significant, non-invasive t…
If successful, this study could validate a novel, patient-friendly oral delivery method for oxytocin, potentially overcoming the limitations of current intranasal or lingual routes. An effective oral oxytocin formulat…
A 12-week randomized, placebo-controlled trial investigated intranasal oxytocin (24 IU BID) for social cognition, psychotic symptoms, and social functioning in schizophrenia.
If successful, this pilot study could pave the way for a novel, non-addictive adjunctive therapy for benzodiazepine withdrawal, potentially transforming how clinicians manage this challenging process. A safe and effec…
The high prevalence and severe consequences of co-occurring stimulant use disorder and opioid use disorder underscore an urgent need for effective, integrated treatments. Current methadone maintenance therapy (MMT) ad…
A successful sublingual Oxytocin formulation could revolutionize PPH prevention, particularly in settings where intravenous access or skilled personnel are limited. This non-injectable route offers a practical, user-f…
While specific results from this completed Phase 2 trial are not yet available, the investigation of intranasal oxytocin for obesity holds significant potential. If positive findings emerge, oxytocin could offer a nov…
This Phase 2 study represents an important step in exploring Oxytocin as a potential therapeutic agent for Posttraumatic Stress Disorder, particularly for its challenging affective symptoms. The investigation into Oxy…
These findings suggest that integrating non-pharmacological interventions like breast massage and VR could offer a valuable, accessible, and drug-free strategy to support new mothers facing lactation challenges. The s…
As this record describes a study protocol (NCT02303418) rather than a completed research paper, specific quantitative results are not yet available. The researchers' primary objective is to rigorously compare the inci…
Augmenting existing, evidence-based psychotherapies for PTSD is crucial to improve treatment response rates and long-term outcomes for individuals suffering from this debilitating condition. If intranasal oxytocin pro…
Postpartum hemorrhage remains a critical concern in maternal health, and identifying simple, non-pharmacological adjuncts to existing treatments is highly valuable. If this study's full results demonstrate a significa…
This research provides crucial insights into the acute pharmacology of 2C-B, demonstrating its dose-dependent effects and unique subjective profile compared to other well-known psychoactive substances. The distinct bl…
This comprehensive meta-analysis provides robust evidence supporting the enhanced efficacy of carbetocin over oxytocin, particularly for PPH prevention in caesarean sections, and highlights the utility of misoprostol …
This research highlights the distinct neurobiological pathways through which vasopressin and oxytocin modulate cognitive functions, even though they are structurally similar. Understanding these differential effects c…
This research highlights oxytocin's broader role in human social cognition and economic decision-making, suggesting it influences how we assign value to objects based on ownership. Understanding this mechanism could p…
Optimizing labor induction protocols is crucial for improving maternal and neonatal outcomes, potentially reducing complications and improving patient experience. If one route of Misoprostol administration proves sign…
Optimizing labor management is crucial for improving maternal and neonatal outcomes, potentially reducing the need for more invasive interventions and lowering healthcare costs. If increased hydration proves effective…
This SingWell proof-of-concept study highlights that group singing offers a holistic, accessible, and enjoyable non-pharmacological intervention for older adults. The observed improvements in mood, social engagement, …
Melatonin's potential as a safe, easily administered, and cost-effective intervention for C-section recovery is a significant finding. If confirmed in larger trials, melatonin could become a valuable adjunct therapy t…
This pivotal study provides robust evidence that sublingual misoprostol is an effective and comparable alternative to intravenous oxytocin for managing primary postpartum hemorrhage. Its significant advantages, includ…
This study provides compelling evidence that Carbetocin is more effective than Oxytocin in preventing PPH in women with multiple risk factors after vaginal delivery. The significant reduction in PPH incidence, blood l…
This research is critical for identifying novel strategies to improve outcomes for individuals suffering from eating disorders, which often have high relapse rates and incomplete recovery. If successful, this study co…
This research highlights the critical role of the gut microbiome in maintaining basal oxytocin homeostasis within the hypothalamus, a key brain region for social and emotional regulation. The selective effect, where b…
This study identifies a novel collicular-hypothalamic pathway critical for social visual awareness, providing a foundational understanding of how the brain integrates visual input with social behavior. The discovery o…
This study provides crucial insights into the risk factors for PBIE, enabling breeders and veterinarians to implement more targeted and effective management strategies. Identifying high-risk mares early can lead to pr…
This research is significant because it identifies a novel, dual-compound approach for managing primary dysmenorrhea, moving beyond symptomatic relief to target underlying mechanisms. The discovery of the Hsp90ab1/p38…
This extensive UK-specific data provides crucial insights into the epidemiology and management of feline dystocia, offering a robust evidence base for veterinary practitioners. The findings highlight specific risk fac…
Understanding the intricate interaction between oxytocin and serotonin is profoundly important for advancing our knowledge of human social behavior and emotional health. Dysregulation in either system is implicated in…
This research provides compelling evidence that pineapple consumption during late pregnancy may serve as a natural, accessible, and cost-effective intervention to promote cervical ripening and optimize labor progressi…
This review significantly advances our understanding of oxytocin's profound and multifaceted role in maternal mental health, extending far beyond its well-known reproductive functions. The findings underscore oxytocin…
The study revealed significant alterations in brain dynamics and molecular profiles in individuals with late-life depression. Specifically, they observed a significant reduction in brain entropy, particularly in the p…
These findings underscore OEA's potential as a novel therapeutic agent for Alcohol Use Disorder, targeting multiple pathways involved in addiction neurobiology and peripheral organ damage. By modulating both central n…
This research provides critical insights into the neurobiological underpinnings of Methamphetamine Use Disorder, highlighting the potential role of neurosteroids and oxytocin in mediating craving, aggression, and emot…
The study was terminated prematurely after enrolling only 5 participants, a significantly lower number than required for a robust pilot assessment. Consequently, no definitive efficacy or safety data comparing the int…
This study provides crucial safety data, reassuring clinicians that both carbetocin and oxytocin are comparably safe for the heart when used for postpartum hemorrhage prevention. Given the global burden of PPH, identi…
If the findings demonstrate a significant reduction in labor pain and anxiety, this study could validate a simple, accessible, and non-pharmacological intervention for childbirth. Empowering birth partners with effect…
While this specific study yielded no data due to its withdrawal, the underlying research question remains highly relevant. Understanding interventions that could improve family interactions is critical for supporting …
Postpartum depression carries grave consequences for maternal-infant bonding and childhood psychological development, making early identification critical. If prenatal oxytocin levels are confirmed as a reliable bioma…
If successful, this study could highlight oxytocin as a promising adjunctive treatment for improving critical social and emotional deficits in schizophrenia and schizoaffective disorder patients. Addressing these symp…