45 studies on Ipamorelin curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This review highlights a critical distinction for peptide users and clinicians: only GLP-1R agonists currently possess reproducible, high-quality evidence for a specific musculoskeletal indication (knee osteoarthritis…
This study provides crucial evidence of the ongoing misuse of GHRP-2 and GHRP-6 in sports and validates a robust analytical method for their detection. The ability to accurately identify these peptides in athlete urin…
Improved and more sensitive detection methods are paramount for maintaining the integrity and fairness of competitive sports. By identifying novel metabolites and optimizing analytical protocols, this research signifi…
The discovery of these novel, orally active growth hormone secretagogues represents a significant advancement in the field of endocrinology and drug development. Oral administration offers a more convenient and patien…
This study marks a significant advancement by identifying Ipamorelin as the first truly selective growth hormone secretagogue, offering a cleaner pharmacological profile. The absence of significant prolactin or cortis…
This research highlights Ipamorelin's potential as a potent and selective growth hormone secretagogue capable of directly stimulating bone growth. Its efficacy, comparable to recombinant human GH in this model, sugges…
The discovery of NN703 as a potent and orally bioavailable GH secretagogue represents a significant advancement in the field of endocrinology. An oral GH secretagogue could revolutionize the treatment paradigm for con…
This research provides critical insights into the pharmacology of ipamorelin, establishing a robust quantitative link between its systemic exposure and its growth hormone-releasing effects in humans. Understanding thi…
This finding is highly significant because it suggests that this novel GHS could potentially be effective even in individuals undergoing glucocorticoid therapy, where GH secretion is often suppressed. This could open …
This foundational research is profoundly significant as it underscores the promising potential of GH secretagogues as a novel therapeutic strategy for managing and preventing conditions characterized by bone loss, suc…
This study reveals a critical GH-independent mechanism by which GHSs can increase body fat, potentially driven by increased feeding and altered metabolic signaling. This finding is highly significant for understanding…
This research provides a crucial mechanistic insight into how GHRPs stimulate growth hormone release, suggesting a significant interaction with the body's endogenous ghrelin system. Understanding this pathway could le…
This research significantly deepens our understanding of ghrelin's structure-activity relationship, particularly concerning its minimal active core and the critical role of specific amino acid positions. The identific…
This research highlights a successful strategy for designing highly potent growth hormone secretagogues by combining structural features from different active compounds. The discovery that re-introducing specific mole…
This research highlights Ipamorelin's potential to mitigate severe side effects of glucocorticoid therapy, which are widely used but often limited by their catabolic impact on bone and muscle. By demonstrating that Ip…
This study provides crucial insights into the long-term effects of Ipamorelin on the pituitary, demonstrating that chronic administration can lead to a sustained enhancement of somatotroph function and GH release capa…
This research successfully identified novel growth hormone secretagogues with significantly improved potency and, crucially, excellent oral bioavailability. The development of orally active GHS is a major step forward…
This study highlights a critical paradox in diabetes: GH hypersecretion coexisting with peripheral GH receptor resistance. This finding suggests that the body attempts to compensate for impaired GH signaling by increa…
This research is significant because it identifies a novel role for Ipamorelin beyond its known growth hormone-releasing effects, demonstrating its ability to directly stimulate insulin secretion. The finding that Ipa…
This research provides the first comprehensive molecular characterization of ghrelin in seabream, a commercially important aquaculture species. Understanding the genetic structure and regulatory elements of seabream g…
This study provides compelling evidence that both growth hormone and growth hormone secretagogues can effectively mitigate the severe catabolic effects of steroid treatment, specifically by improving nitrogen balance …
This study provides compelling evidence that ipamorelin, a novel ghrelin mimetic, can effectively mitigate the symptoms and accelerate recovery from postoperative ileus in a preclinical model. The observed improvement…
This study provides a highly sensitive and robust analytical tool that significantly enhances the capabilities of anti-doping laboratories to detect GHRP abuse. By simultaneously identifying both parent GHRPs and thei…
This research highlights ipamorelin's potential as a novel therapeutic agent for managing postoperative ileus by directly addressing gastric dysmotility and associated inflammation. Its ability to accelerate gastric e…
This advanced analytical method significantly enhances anti-doping efforts by providing a highly sensitive, robust, and expandable tool for detecting a broad panel of small prohibited peptides. The ability to detect t…
Understanding these specific metabolic pathways is crucial for anti-doping efforts, enabling the development of more sensitive and specific detection methods for the misuse of performance-enhancing GHRPs. This researc…
This advanced analytical method provides a crucial tool for anti-doping agencies to combat the illicit use of GHRPs in both equine and human sports. By enabling reliable and high-throughput detection, it helps ensure …
This study provides compelling early evidence that ipamorelin, by mimicking the action of ghrelin (a hormone that stimulates appetite and GI motility), can effectively accelerate gastrointestinal recovery after bowel …
This research significantly enhances anti-doping capabilities by providing specific, long-lasting biomarkers for GHRPs administered nasally. The identification of these metabolites means that athletes misusing these s…
This detailed structure-activity relationship analysis provides invaluable insights for the rational design of next-generation peptidic growth hormone secretagogues. Understanding how specific amino acid changes impac…
This pilot study provides compelling evidence that a specialized doping control container can substantially enhance the stability of urine samples, ensuring the accurate detection of prohibited substances over extende…
This study unequivocally highlights the severe public health risks associated with the use of unregulated black market growth-promoting products. Consumers are frequently exposed to mislabeled, contaminated, or entire…
This groundbreaking discovery represents a significant new challenge for global anti-doping agencies and laboratories, as these glycine-modified GHSs are unlikely to be detected by current, standard screening protocol…
This research demonstrates that incorporating a meta-carborane scaffold can effectively improve the metabolic stability of peptide agonists without compromising their potency or selectivity for the ghrelin receptor. T…
This review underscores the potential of growth hormone secretagogues as a valuable therapeutic option for managing body composition in hypogonadal males, especially those who may not fully respond to or tolerate trad…
This research is significant as it expands our understanding of ghrelin's role beyond metabolism and growth, specifically highlighting its influence on reproductive physiology in non-mammalian vertebrates. For the aqu…
This research highlights the significant potential of GHS-R1a agonists like anamorelin and ipamorelin as novel therapeutic agents for managing chemotherapy-induced cachexia and emesis. The dual benefit of anamorelin i…
These findings suggest that Ipamorelin could be a promising therapeutic agent for conditions characterized by growth hormone deficiency, sarcopenia, or osteoporosis. Its selective action as a growth hormone secretagog…
This study provides compelling evidence that ipamorelin can significantly accelerate recovery from post-operative ileus, offering a potential breakthrough in managing this common surgical complication. The observed 35…