162 studies on Thymosin class curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This study provides compelling evidence that Thymosin alpha 1 can significantly enhance the efficacy of existing immuno-oncology treatments, specifically checkpoint inhibitors, by modulating the tumor microenvironment…
This pilot trial's preliminary findings are significant as they highlight a potential new prophylactic strategy for an extremely vulnerable patient population. If confirmed in larger studies, Thymalfasin (Ta1) could b…
This research highlights the transformative potential of metagenomic next-generation sequencing (mNGS) as a rapid and highly sensitive diagnostic tool for adenovirus infections in immunocompromised patients. Early and…
This research provides compelling evidence that Thymosin α1 possesses significant immunomodulatory properties that could be highly beneficial in managing SARS-CoV-2 infection. By dampening the excessive inflammatory r…
This study provides compelling evidence that Thymosin alpha 1 can effectively restore critical aspects of immune homeostasis in patients suffering from Long COVID. The observed improvements in T cell subsets, reductio…
Thymosin α1 demonstrates potent immunomodulatory and antiviral effects, significantly improving survival and reducing viral load in a severe influenza model. Its ability to enhance both innate and adaptive immune resp…
This systematic review underscores the significant therapeutic potential of thymosin drugs as a valuable addition to the current arsenal against lung cancer. Their ability to modulate the immune system offers a distin…
The Thymalfasin treatment group demonstrated significantly faster clinical recovery compared to the control group. The median time to clinical discharge was 14 days for Thymalfasin patients, markedly shorter than the …
This research highlights Thymosin α1's potential as a significant immunomodulator in the context of COVID-19, offering critical insights into its mechanism of action at a cellular level. Understanding these precise im…
This meta-analysis provides compelling evidence supporting the beneficial role of Thymosin Alpha-1 as an adjunctive therapy for moderate to critical COVID-19 patients. Its immunomodulatory properties, which help resto…
This robust and expanding patenting activity unequivocally underscores the escalating commercial and clinical interest in thymosin peptides as a promising class of therapeutics. The identification of rapidly emerging …
This study suggests that thymosin α1 could serve as a valuable adjunctive therapy for HIV immunological nonresponders, offering a pathway to restore crucial immune functions. By boosting CD4+ T-cell counts and improvi…
This comprehensive review solidifies the evidence base for Thymosin Alpha 1's role as a safe and effective immunomodulatory agent in human medicine. The consistent safety profile and demonstrated efficacy across multi…
Targeted immune-enhancing strategies could represent a critical adjunct therapy for patients suffering from Acute Necrotizing Pancreatitis (ANP), particularly those with co-existing metabolic abnormalities. This appro…
This paper strongly suggests that Thymosin Alpha-1 (Ta1), with its broad and beneficial effects on the immune system, is an ideal molecule for phenotypic drug discovery, offering a promising avenue for treating comple…
This case report highlights the potential of combining PD-1 inhibitors with SBRT, GM-CSF, and thymosin alpha-1 as a novel strategy to overcome resistance in metastatic breast cancer. The observed robust clinical respo…
This research highlights a novel strategy to overcome a significant hurdle in oncolytic adenovirus (OAV) therapy: the immunosuppressive tumor microenvironment. Thymosin α1's ability to reprogram M2 macrophages into an…
This meta-analysis provides compelling evidence supporting the use of Thymosin Alpha 1 as an effective adjunctive therapy for managing acute exacerbations of COPD. The consistent improvements in hospital stay and recu…
This phase 3 trial provides robust, high-level evidence for the efficacy and safety of Thymosin α1 as an adjunctive therapy for sepsis, a condition with persistently high mortality and morbidity. Given the significant…
This study provides compelling initial evidence that Thymosin alpha-1 may offer a novel and effective treatment strategy for depression in CVID patients, addressing both immune dysregulation and mood symptoms. The obs…
This study provides compelling evidence that combining hypofractionated radiotherapy with a PD-1 inhibitor, GM-CSF, and thymosin-α1 can significantly enhance anti-tumor responses in patients with advanced metastatic s…
This umbrella review provides compelling evidence that Ulinastatin is a beneficial adjunctive therapy for sepsis, significantly improving patient survival and reducing organ dysfunction. The consistent findings across…
This study highlights the potential of thymosin alpha-1 to enhance the efficacy of established targeted and immunotherapies for unresectable HCC, a disease with high unmet medical need. The observed 45% objective resp…
Acute type A aortic dissection (ATAAD) surgery carries a high risk of complications, and current treatments lack targeted strategies for immune modulation to prevent organ failure. A successful outcome for the PANDA I…
This comprehensive meta-analysis provides strong evidence that Thymosin alpha 1 (Tα1), an immunomodulatory peptide, can effectively reduce inflammation and prevent infections in patients with severe acute pancreatitis…
This research provides compelling in vitro evidence for the direct anti-proliferative effects of Thymosin Alpha 1 on various cancer cell lines and its potent ability to activate key immune cell subsets. The key implic…
This comprehensive meta-analysis provides strong evidence supporting the use of thymosin α1 as an effective adjunctive therapy for sepsis, a condition with devastating mortality rates. The findings suggest that thymos…
This research is highly significant because it suggests a novel strategy to augment the efficacy of current Pulmonary Tuberculosis treatment, potentially leading to faster recovery times and improved patient outcomes.…
This research is highly significant as it identifies Thymosin α1 as a promising therapeutic agent for pulpitis by targeting ferroptosis, a previously underexplored mechanism in dental inflammation. The ability of Thym…
The development of Refnot represents a significant advancement, offering a novel and potentially safer strategy to combat the multifaceted challenges of age-related immune decline and chronic inflammation. By combinin…
This study highlights Zerumbone as a promising therapeutic agent for triple negative breast cancer by effectively targeting CD1d and inhibiting the critical process of EMT. Given the aggressive nature of TNBC and its …
This research highlights the significant potential of Thymosin Alpha 1 (Tα1) as an immunotherapeutic agent to overcome T cell exhaustion in chronic diseases. The observed 'reset' of CD8 T cells suggests Tα1 could be a…
This compelling case report underscores the critical need for heightened clinical vigilance and careful patient selection when considering combination therapies involving immune checkpoint inhibitors and other immunom…
This research is critically important for anti-doping efforts in sports, as it provides a definitive chemical signature for a suspected performance-enhancing substance. By identifying Ac-LKKTETQ as the active componen…
This study provides a crucial analytical tool for anti-doping laboratories worldwide, enabling the effective detection of TB-500 in equine sports. The high sensitivity and specificity of the LC-MS method will signific…
This research represents a pivotal advancement in equine anti-doping efforts, providing a powerful and much-needed analytical tool for regulatory bodies and anti-doping laboratories worldwide. By significantly improvi…
This review is paramount for safeguarding the integrity of sports and ensuring a level playing field for athletes globally. By outlining the most effective analytical strategies, it provides a roadmap for anti-doping …
This review is critical for advancing anti-doping science and ensuring fair play in competitive sports. By synthesizing the current state of detection methods and outlining future directions, it provides a roadmap for…
This research provides critical tools for anti-doping laboratories to predict and identify peptide metabolites, significantly improving detection windows for prohibited substances. By understanding the metabolic fate …
This study provides a robust, high-throughput, and highly efficient method for extracting small peptides from urine, which is critical for advancing various fields. Improved extraction efficiency means more accurate a…