54 studies on Antimicrobial peptide class curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
Identifying specific biomarkers like 25(OH)D3 and LL-37 in peri-implant sulcus fluid could offer valuable insights into the pathogenesis of peri-implant diseases. If significant correlations are found, these markers c…
This research uncovers a novel host-directed mechanism by which LL-37 exerts its antiviral effects, moving beyond direct viral targeting to modulating the host's own defenses. By identifying the EGFR-ERK-Stac axis, th…
This research provides a fundamental understanding of how a host antimicrobial peptide, LL-37, directly modulates the CovRS two-component system, a critical virulence regulator in Group A Streptococcus (GAS). The find…
Understanding the intricate link between Obstructive Sleep Apnea, immune dysregulation, and neutrophil extracellular traps could open new therapeutic avenues for OSA-related systemic complications. If OSA significantl…
This comprehensive review highlights the significant potential of secretome therapy as an innovative approach for treating craniofacial fractures. By naturally boosting the production of critical bone-repairing substa…
These findings are critical for understanding the nuanced roles of antimicrobial peptides in various inflammatory diseases, moving beyond a one-size-fits-all view. The discovery that AMPs contribute variably depending…
This withdrawn study highlights a missed opportunity to explore a potentially significant adjunctive therapy for tuberculosis. If completed, it could have provided valuable insights into whether Vitamin D supplementat…
This study's design highlights the potential for nutritional intervention to support surgical recovery by optimizing a key immune modulator. If positive results were found, optimizing vitamin D levels could become a s…
Understanding the relationship between vitamin D, hCAP18, and Chronic Kidney Disease is critical, as CKD patients often have compromised immune systems and are prone to infections. If successful, this research could h…
If successful, this Phase II trial could provide crucial evidence supporting umbilical mesenchymal stromal cells as a novel cellular immunotherapy for septic shock, a condition with high unmet medical need. The compre…
The potential of Mesenchymal Stem Cells to modulate inflammation and promote tissue repair offers a novel and much-needed therapeutic strategy for septic shock, a condition with alarmingly high mortality rates and sig…
The provided abstract outlines the study's design and objectives, focusing on the diagnostic potential of LL-37 and anti-inflammatory cytokines in periodontal disease, rather than presenting specific results from the …
If the findings from this clinical trial prove positive, this research could establish LL-37 cream as a novel and highly effective topical treatment option for the management of challenging diabetic foot ulcers. Given…
If this study confirms the beneficial effects observed in prior research for these specific probiotic strains, it could significantly advance strategies for supporting early infant health. Optimizing the gut microbiom…
Understanding the interplay between vitamin D and LL-37 in peri-implant diseases could significantly advance our diagnostic and therapeutic approaches. If a clear correlation is established, it could lead to novel str…
The identification of salivary Cathelicidin LL-37 as a highly accurate marker for oral potentially malignant lesions represents a pivotal advancement in early cancer detection. This non-invasive diagnostic approach co…
If the planned trial demonstrates positive results, it could establish Limosilactobacillus fermentum LF61 as a scientifically validated dietary supplement for enhancing both gut and immune health. This would provide c…
Understanding the genetic basis of eczema herpeticum is crucial for identifying individuals at highest risk and developing targeted interventions. Pinpointing specific genetic variants could lead to more precise diagn…
The termination of this early-phase study for GSK2793660 highlights the significant challenges and high attrition rates inherent in drug development, especially for complex and chronic conditions like Bronchiectasis. …
Understanding the impact of passive smoking on LL-37 levels could provide a novel, non-invasive biomarker for early detection of periodontal disease risk in children. If LL-37 levels are significantly altered, it coul…
This research is crucial because it investigates a novel approach to managing CRSwNP, a condition often resistant to conventional therapies, by targeting its microbial component. If successful, Dupilumab could offer a…
If this trial demonstrates that Calcitriol effectively increases cathelicidin levels in sepsis patients, it would provide strong evidence for a direct therapeutic role of vitamin D in enhancing host defense. This coul…
The premature termination of this study represents a missed opportunity to gather crucial data on the potential benefits of high-dose Vitamin D3 for immune enhancement in HIV+ individuals and smokers. Had it been comp…
Understanding the intricate links between lifestyle factors and periodontal disease is crucial for developing holistic health strategies. If significant associations are identified, this research could inform personal…
Understanding the balance between the antimicrobial benefits of mouthwashes and their potential impact on the body's natural defenses is crucial for oral health. If widely used mouthwashes significantly reduce hBD2 an…
This research holds profound implications for optimizing COPD treatment strategies, particularly for patients living in areas with high air pollution. If inhaled corticosteroids are found to increase vulnerability to …
This research holds significant implications for understanding vitamin D physiology and optimizing supplementation protocols for populations living in environments with minimal sun exposure. Should the findings demons…
Understanding the interplay between LL-37, Vitamin D3, and smoking in the context of chronic periodontitis is vital for developing targeted therapies. If significant findings had been reported, they could have reveale…
The findings from this review are profoundly significant, as they underscore the potential of host defense peptides (HDPs) as a novel and safer therapeutic class for inflammatory bowel diseases (IBDs). Given the subst…
This discovery provides crucial insights into the molecular mechanisms underlying the synergistic action of human antimicrobial peptides, which is vital for combating multidrug-resistant bacterial infections. Understa…
A deeper and more integrated understanding of rosacea's pathogenesis is crucial for developing more effective and targeted treatments. This review's findings could pave the way for novel therapeutic strategies that ad…
This research provides a novel and fundamental understanding of how fever enhances host bacterial defense, suggesting that fever is not just a symptom but an active, beneficial immune strategy. The finding that fever …