149 studies on Growth factor class curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
A successful Phase 3 trial of Saizen® for Idiopathic Short Stature (ISS) could significantly impact pediatric endocrinology by providing robust evidence for a standardized and effective treatment protocol. For clinici…
If successful, this combination therapy could offer a refined approach for GHD patients with glucose dysregulation. Current GH replacement protocols, while beneficial for body composition, can sometimes worsen insulin…
Understanding the long-term effects of early Oxytocin intervention in Prader-Willi Syndrome (PWS) is crucial for establishing potential disease-modifying therapies. If early Oxytocin treatment demonstrates sustained b…
The continuation of similar monitoring efforts, as seen in the ongoing Increlex® Global Registry (NCT00903110), underscores the importance of continuous post-market surveillance for this patient population.
This large-scale observational study is critical for understanding the true health impact of androgenic anabolic steroid (AAS) use among recreational athletes, a population with alarmingly high prevalence. The finding…
The investigation into recombinant human insulin-like growth factor I (IGF-I) as a treatment for hyperinsulinism is significant due to the limitations of existing therapies. If IGF-I effectively reduces insulin secret…
This study provides promising early evidence that recombinant human growth hormone (rhGH) could be a safe and effective therapeutic option for adolescents grappling with NAFLD. The observed improvements in liver fat, …
If the study demonstrates positive results, it could establish recombinant human growth hormone (rhGH) as a critical and effective treatment for short stature in children with chronic kidney disease prior to transplan…
This study is crucial for strengthening the global fight against doping, particularly concerning growth hormone abuse. By successfully generating standardized, positive control samples, it provides anti-doping laborat…
This study is significant because it could elucidate the precise role of IGF-1 in the pathogenesis of vitiligo, specifically its interaction with oxidative stress. Understanding this mechanism could open new avenues f…
Poor ovarian reserve is a significant and distressing challenge in IVF, often leading to repeated cycle cancellations and emotional burden for patients. The successful completion of this Phase 3 trial suggests a promi…
Despite its termination, this study highlights the ongoing effort to understand and optimize treatments for Primary IGF-1 Deficiency, a condition causing significant growth failure in children. The intent was to gathe…
While the specific, detailed results from this completed Phase 2 clinical trial (NCT01777542) are not included in the provided record, the study's primary objective was to evaluate the efficacy and safety of recombina…
This Phase 2 trial represents a significant step in exploring targeted treatments for Phelan-McDermid Syndrome, a condition with limited therapeutic options. If IGF-1 proves safe and effective in subsequent studies, i…
This study is crucial because it will provide much-needed long-term safety and effectiveness data for Sogroya (somapacitan) in a real-world setting, which is often different from controlled clinical trials. For patien…
This research is crucial because it could lead to a more personalized and tolerable preventative strategy for breast cancer in premenopausal women. By refining the Tamoxifen dose, the study hopes to improve patient ad…
The development of a sustained-release human growth hormone (SR-hGH) formulation could significantly improve treatment adherence and quality of life for children with Idiopathic Short Stature (ISS) by reducing injecti…
The successful completion of this Phase 1 trial is a crucial step towards providing a more convenient treatment option for children with Growth Hormone Deficiency. A long-acting growth hormone like somapacitan could s…
Understanding the acute anabolic and inflammatory effects of testosterone in older men is crucial for optimizing sarcopenia treatments. This research contributes to the knowledge base required to develop safer and mor…
This study successfully focused on the development, implementation, and initial validation of the MAGHD App/MAGHD Framework as a novel self-assessment system for Adult Growth Hormone Deficiency (AGHD) management. The …
The successful identification of optimal exercise and nutritional strategies for sarcopenia could revolutionize care for older adults. This research has the potential to provide evidence-based guidelines for clinician…
This research is significant because it directly addresses a critical unmet need for treatments that can improve connective tissue strength in Ehlers-Danlos Syndrome. If IGF-I proves effective in stimulating collagen …
The concept of continuous subcutaneous hydrocortisone infusion holds significant promise for patients with Addison's Disease, particularly those with co-existing Type 1 Diabetes, by potentially mimicking the body's na…
This study provides compelling evidence that endogenous FGF21 plays a critical protective role against retinal inflammation and damage. The findings suggest that maintaining adequate FGF21 levels could be a viable the…
This systematic review provides a comprehensive synthesis of the endocrine pathways connecting birth size to infant metabolic programming, highlighting the crucial roles of placental hormones and IGF-1. Understanding …
This pioneering study represents a significant step towards a proactive and personalized approach to sarcopenia management, potentially transforming how this debilitating condition is diagnosed and treated globally. B…
The termination of this trial highlights the significant challenges in developing and testing combination therapies for complex conditions like IGF-1 deficiency and short stature. While this specific study did not yie…
Sandostatin LAR is a well-established treatment for acromegaly, and this study aimed to refine our understanding of its comprehensive benefits beyond just hormone suppression. Demonstrating clear improvements in metab…
This study is significant because it investigated the impact of very early initiation of growth hormone therapy in Turner Syndrome, a critical period for growth and development. The findings, once fully published, cou…
This study is significant because it explores the practical application of lanreotide Autogel 120 mg at extended dosing intervals, potentially offering a more convenient and less burdensome treatment schedule for pati…
The successful completion of this Phase 3 trial is a significant step towards developing an effective treatment for primary IGF-1 deficiency, a condition with limited therapeutic options. rhIGF-1 (mecasermin) holds su…
This pioneering single-patient study represents an early, crucial exploration into a novel therapeutic approach for a complex and rare genetic disease. Targeting low IGF-1 levels in Werner's Syndrome patients with ost…
This comprehensive review validates the traditional uses of velvet antler with a robust body of modern scientific evidence, establishing a strong foundation for its continued investigation as a potent therapeutic agen…
This research highlights that serum IGF-1 could serve as a valuable biomarker for predicting the progression of anxiety in Parkinson's disease patients, potentially allowing for earlier intervention. Identifying patie…
This study represents a significant advancement in the management of pediatric growth hormone deficiency, offering a more convenient treatment regimen that could substantially improve patient adherence and quality of …
This Phase II trial is profoundly important because it seeks to identify a safer, more tolerable preventative strategy for breast cancer in high-risk post-menopausal women. Current preventative doses of Exemestane and…
The investigation of novel agents like CP-751,871 in combination with established chemotherapy is crucial for improving outcomes in advanced NSCLC, where new therapeutic strategies are desperately needed. Understandin…
This is a proceedings publication from the 49th Annual Meeting of the Austrian Society of Surgery, held in Innsbruck, May 21-23, 2008, guest-edited by Beate Neuhauser, Dietmar Öfner, Elfriede Ruttmann-Ulmer, and Anton…
Understanding the acute molecular response to muscle reloading is critical for optimizing rehabilitation protocols after periods of disuse. This study highlights that autophagy and myogenesis pathways are rapidly acti…
Accurate and reliable non-invasive prenatal screening for 22q11.2 deletion syndrome is crucial for early diagnosis and informed decision-making for expectant parents. The internal analytical verification of a targeted…
This research highlights Kisspeptin's potential as a therapeutic agent for mitigating the adverse effects of maternal hypothyroidism on pregnancy outcomes. The restoration of placental mTOR signaling and glucose homeo…