111 studies on Cathelicidin class curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This research provides compelling evidence for the therapeutic utility of selectively modulating ILC subsets to combat chronic inflammatory conditions such as IBD. The ability of ILC-Mod-1 to rebalance ILC2/ILC3 popul…
Identifying specific biomarkers like 25(OH)D3 and LL-37 in peri-implant sulcus fluid could offer valuable insights into the pathogenesis of peri-implant diseases. If significant correlations are found, these markers c…
This research uncovers a novel host-directed mechanism by which LL-37 exerts its antiviral effects, moving beyond direct viral targeting to modulating the host's own defenses. By identifying the EGFR-ERK-Stac axis, th…
This research provides a fundamental understanding of how a host antimicrobial peptide, LL-37, directly modulates the CovRS two-component system, a critical virulence regulator in Group A Streptococcus (GAS). The find…
Understanding the intricate link between Obstructive Sleep Apnea, immune dysregulation, and neutrophil extracellular traps could open new therapeutic avenues for OSA-related systemic complications. If OSA significantl…
This research provides a critical link between innate immunity and lipoprotein metabolism in the context of atherosclerosis, highlighting LL-37-Apo B100 complexes as a novel pathogenic entity. The findings suggest tha…
This comprehensive review highlights the significant potential of secretome therapy as an innovative approach for treating craniofacial fractures. By naturally boosting the production of critical bone-repairing substa…
This study highlights the potential of LL-37-specific adaptive immune responses as novel biomarkers for distinguishing different clinical phenotypes of ASCVD, particularly between stable and acute forms. Identifying s…
These findings are critical for understanding the nuanced roles of antimicrobial peptides in various inflammatory diseases, moving beyond a one-size-fits-all view. The discovery that AMPs contribute variably depending…
This research provides crucial mechanistic insights into how air pollution directly compromises the body's first line of defense against respiratory pathogens. The findings underscore the significant public health imp…
This research highlights the significant potential of LL-37 peptide as a novel therapeutic agent for treating complex periapical infections, especially given its broad-spectrum activity and biofilm-disrupting capabili…
This withdrawn study highlights a missed opportunity to explore a potentially significant adjunctive therapy for tuberculosis. If completed, it could have provided valuable insights into whether Vitamin D supplementat…
This research underscores the substantial potential of taurine as an effective dietary supplement to improve the welfare, health, and survival rates of fish during highly stressful events like transportation. By effec…
This research highlights a novel and promising therapeutic strategy for Glioblastoma Multiforme (GBM) by leveraging engineered exosomes to simultaneously induce cancer cell death and correct gut dysbiosis. The ability…
This research highlights a novel mechanism by which the tumor microenvironment, specifically through Neutrophil Extracellular Traps (NETs), can promote inflammation and potentially drive Triple-Negative Breast Cancer …
This comprehensive review underscores that Neutrophil Extracellular Traps (NETs) are not merely bystanders but active contributors to the pathology of severe exocrine pancreatic diseases, including acute pancreatitis …
This novel platform provides an efficient, unbiased, and high-throughput approach for discovering functional polysaccharide-binding peptides from vast natural sequence diversity. The identified peptides, particularly …
This research significantly advances our understanding of how NTHi resists host immunity, identifying SapA as a crucial virulence factor. Targeting SapA could represent a novel strategy for developing new antibacteria…
This research provides a fundamental understanding of how bacterial membrane architecture influences the efficacy of antimicrobial peptides, offering crucial insights into their mechanism of action. By identifying tha…
This research provides crucial insights into the structure-activity relationship of LL-37, demonstrating that targeted modifications can significantly enhance its antimicrobial properties and specificity. The discover…
This study's design highlights the potential for nutritional intervention to support surgical recovery by optimizing a key immune modulator. If positive results were found, optimizing vitamin D levels could become a s…
Understanding the relationship between vitamin D, hCAP18, and Chronic Kidney Disease is critical, as CKD patients often have compromised immune systems and are prone to infections. If successful, this research could h…
This study provides compelling evidence that passive smoking significantly impairs oral health in children, not only by exacerbating oxidative stress but also by compromising crucial innate immune defenses. The findin…
If successful, this Phase II trial could provide crucial evidence supporting umbilical mesenchymal stromal cells as a novel cellular immunotherapy for septic shock, a condition with high unmet medical need. The compre…
The potential of Mesenchymal Stem Cells to modulate inflammation and promote tissue repair offers a novel and much-needed therapeutic strategy for septic shock, a condition with alarmingly high mortality rates and sig…
The provided abstract outlines the study's design and objectives, focusing on the diagnostic potential of LL-37 and anti-inflammatory cytokines in periodontal disease, rather than presenting specific results from the …
If the findings from this clinical trial prove positive, this research could establish LL-37 cream as a novel and highly effective topical treatment option for the management of challenging diabetic foot ulcers. Given…
If this study confirms the beneficial effects observed in prior research for these specific probiotic strains, it could significantly advance strategies for supporting early infant health. Optimizing the gut microbiom…
Understanding the interplay between vitamin D and LL-37 in peri-implant diseases could significantly advance our diagnostic and therapeutic approaches. If a clear correlation is established, it could lead to novel str…
The identification of salivary Cathelicidin LL-37 as a highly accurate marker for oral potentially malignant lesions represents a pivotal advancement in early cancer detection. This non-invasive diagnostic approach co…
If the planned trial demonstrates positive results, it could establish Limosilactobacillus fermentum LF61 as a scientifically validated dietary supplement for enhancing both gut and immune health. This would provide c…
Understanding the genetic basis of eczema herpeticum is crucial for identifying individuals at highest risk and developing targeted interventions. Pinpointing specific genetic variants could lead to more precise diagn…
The termination of this early-phase study for GSK2793660 highlights the significant challenges and high attrition rates inherent in drug development, especially for complex and chronic conditions like Bronchiectasis. …
Understanding the impact of passive smoking on LL-37 levels could provide a novel, non-invasive biomarker for early detection of periodontal disease risk in children. If LL-37 levels are significantly altered, it coul…
This research is crucial because it investigates a novel approach to managing CRSwNP, a condition often resistant to conventional therapies, by targeting its microbial component. If successful, Dupilumab could offer a…
If this trial demonstrates that Calcitriol effectively increases cathelicidin levels in sepsis patients, it would provide strong evidence for a direct therapeutic role of vitamin D in enhancing host defense. This coul…
The premature termination of this study represents a missed opportunity to gather crucial data on the potential benefits of high-dose Vitamin D3 for immune enhancement in HIV+ individuals and smokers. Had it been comp…
Chronic inflammation and incomplete immune reconstitution remain significant challenges for HIV-infected individuals, even with effective antiretroviral therapy (ART). This study's approach, if successful, could offer…
Understanding the intricate links between lifestyle factors and periodontal disease is crucial for developing holistic health strategies. If significant associations are identified, this research could inform personal…
This study provides robust evidence supporting Ivermectin's direct anti-inflammatory properties in addition to its known antiparasitic effects, offering a more complete understanding of its therapeutic benefits in ros…