188 studies on Mitochondrial peptide class curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This study highlights the neuroprotective and regenerative potential of Elamipretide (SS-31) in the context of spinal cord injury. By directly targeting mitochondrial dysfunction and promoting neural remodeling, Elami…
This research highlights MOTS-c's potential as a novel and promising biomarker for assessing the severity of myocardial ischemia-reperfusion injury (IRI) in acute myocardial infarction (AMI) patients. Identifying pati…
This mechanistic understanding is crucial because it identifies mitochondrial dysfunction as a central, actionable target for preventing β-cell loss in T2DM. By elucidating the precise links between mitochondrial heal…
The study demonstrated that Humanin treatment significantly improved crucial semen quality parameters. Sperm motility, viability, and membrane integrity were all markedly enhanced compared to untreated controls.
This research highlights humanin's strong potential as a non-invasive, accessible biomarker for early detection and diagnosis of breast cancer. Its high sensitivity and specificity could significantly improve screenin…
This research highlights Humanin's conserved yet evolutionarily tuned role in protecting against mitochondrial dysfunction and oxidative stress across mammals. The observed species-specific differences provide critica…
The review consistently highlighted that Humanin demonstrated potent and broad-spectrum anti-inflammatory and cytoprotective effects across diverse experimental models. In several mouse models of acute inflammation, H…
This research provides a novel molecular mechanism explaining how the Mediterranean diet may exert its cardioprotective effects, specifically through its influence on mitochondrial microproteins like Humanin and SHMOO…
Identifying an early and reliable biomarker for AKI after heart transplantation is critically important, as it could enable clinicians to intervene sooner, potentially preventing severe kidney damage and improving pat…
Understanding the precise role of Humanin in the context of cardiac surgery outcomes could significantly advance patient care and risk management. If specific Humanin levels are found to correlate with, or predict, th…
Identifying novel and early biomarkers for Acute Kidney Injury is critically important for improving patient outcomes and guiding therapeutic strategies. If Humanin proves to be a reliable predictive marker, it could …
This research highlights Humanin's significant potential as a novel therapeutic agent for neurodegenerative diseases like Alzheimer's and Parkinson's, as well as other conditions involving mitochondrial dysfunction an…
This research is significant because it identifies Quercetin, a natural flavonoid, as a potential therapeutic agent for renal ischemia-reperfusion injury, a condition with limited current treatment options. The findin…
This review is crucial because it highlights the urgent need for effective treatments for dry AMD, a condition affecting millions globally with no current cure. The identification of innovative technologies like gene …
This groundbreaking study introduces a highly effective and targeted strategy for delivering thermogenic agents, presenting a novel and potentially safer pathway for obesity treatment. By specifically boosting mitocho…
This comprehensive review underscores the critical role of mitochondria as a promising therapeutic target for preventing and treating acute kidney injury (AKI) caused by ischemia-reperfusion injury (IRI). By elucidati…
This review significantly advances our understanding of Diabetic Kidney Disease (DKD) by firmly establishing mitochondrial dynamics as a crucial pathogenic mechanism. Identifying specific pathways within mitochondrial…
These findings suggest that MOTS-c could serve as a novel biomarker for PCOS diagnosis or severity, and its genetic variants might identify individuals at higher risk. Understanding this metabolic link opens avenues f…
This research highlights MOTS-c as a promising therapeutic candidate for conditions involving impaired spermatogenesis. By targeting SLC7A11 and suppressing ferroptosis, MOTS-c offers a novel mechanism to protect germ…
SS-31 represents a highly promising therapeutic strategy for a wide range of conditions characterized by mitochondrial dysfunction, offering a direct and targeted approach to cellular protection. Its unique ability to…
This ongoing TONE Trial holds immense importance as it seeks to provide robust, high-quality evidence for the efficacy of structured, high-intensity combined exercise in a particularly vulnerable patient population: t…
Understanding the role of exercise in post-diagnosis breast cancer care is crucial for improving patient outcomes and quality of life. If this pilot study demonstrates positive changes in body composition and identifi…
The ability to accurately predict cardiovascular mortality in Type 2 Diabetes Mellitus patients with Coronary Artery Disease is paramount for enhancing patient care and improving long-term outcomes. Positive findings …
MOTS-c is a novel mitochondrial-derived peptide with potential roles in metabolic regulation, including glucose homeostasis. If this Phase 2a study demonstrates significant improvements in insulin sensitivity and a fa…
This review provides novel insights into the critical role of mitochondrial calcium dysregulation in heart failure, underscoring its potential as a therapeutic target. The discussion of mCa2+ uniporter (MCU) inhibitor…
This research highlights SS-31 as a promising therapeutic agent for tendinopathy by targeting mitochondrial health, a critical factor in tissue repair and regeneration. The ability of SS-31 to protect mitochondria and…
This research highlights the significant potential of Elamipretide as a therapeutic agent for promoting healthy aging and potentially extending healthspan. By targeting mitochondrial function, Elamipretide appears to …
Sepsis-associated encephalopathy (SAE) represents a critical unmet medical need, with current treatments offering limited efficacy against its severe cognitive sequelae. This research provides compelling evidence that…
This research underscores aging as a critical and independent risk factor that significantly amplifies the heart's vulnerability to dietary sugar. The findings suggest that older individuals may require more stringent…
This study provides compelling evidence that SS-31 peptide can mitigate severe cardiac mitochondrial dysfunction in a genetic model of Barth syndrome, suggesting its potential as a novel therapeutic strategy. By impro…
This study highlights the inherent resilience of the gut microbiota in a non-Western population, suggesting that while antibiotics cause significant disruption, the microbiome can largely recover its diversity and com…
This research significantly advances our understanding of spinal cord injury pathology by identifying a critical role for cPLA2-mediated lysosomal membrane permeabilization in driving pyroptosis. The finding that Elam…
This research highlights the potential of synovial fluid mtDNA as a novel, non-invasive biomarker for assessing cartilage damage severity after joint injury. Such a biomarker could significantly improve early diagnosi…
This review highlights the critical role of mitochondrial health in NAFLD pathogenesis and underscores the immense potential of mitochondrial-targeted therapies. By summarizing the efficacy of various compounds and me…
This research highlights SS-31 as a promising therapeutic agent for combating age-related cerebrovascular dysfunction by directly targeting mitochondrial health. The observed proteomic improvements suggest that SS-31 …
This research is significant because it identifies a specific mechanism by which elamipretide (SS-31) can counteract age-related mitochondrial decline. By improving ADP sensitivity and enhancing ANT function, SS-31 co…
Understanding these intricate molecular mechanisms is profoundly crucial for the rational design and optimization of more effective mitochondria-targeted therapeutics. By elucidating precisely how specific peptide seq…
This research provides compelling evidence for Elamipretide's therapeutic potential in treating Idiopathic Pulmonary Fibrosis by targeting a crucial inflammatory and fibrotic pathway. The ability of Elamipretide to mo…
The successful application of SS-31 as a mitochondrial-targeted antioxidant represents a significant advancement in therapeutic strategies for diseases driven by mitochondrial pathology. By directly addressing the roo…
This review underscores the transformative potential of biomaterial-based drug delivery for inflammasome inhibitors, offering a pathway to overcome current therapeutic limitations. By enabling targeted and sustained r…
This research highlights mitochondrial ROS as a crucial mechanistic driver of calcium alternans in atrial myocytes, offering a novel perspective on the pathogenesis of atrial fibrillation (AF). The findings suggest th…
This research is significant because it identifies a novel therapeutic strategy for POCD, a condition with limited effective treatments, especially in the elderly. By targeting mtDNA-cGAS-STING signaling and activatin…
This research highlights SS-31 as a promising therapeutic candidate for hepatic fibrosis by simultaneously targeting mitochondrial dysfunction and NLRP3 inflammasome-mediated inflammation. The ability of SS-31 to dire…