MOTS-C Levels Linked to Obesity, Inflammation, and Metabolic Dysfunction
MOTS-C levels ın ındividuals with and without obesity and ıts association with ınflammation, insulin resistance and endothelial dysfunction.
Background
Obesity is a global health crisis, profoundly impacting public health by increasing the risk of chronic inflammation, insulin resistance, and endothelial dysfunction, which contribute to cardiovascular disease and type 2 diabetes. Mitochondrial-derived peptides like MOTS-C (mitochondrial open reading frame of the 12S rRNA-c) regulate metabolic homeostasis. However, its specific association with these pathological markers in human obesity remains underexplored, limiting our understanding of its role in disease progression.