Humanin's Potential as Early Marker for Kidney Injury After Heart Transplant

Acute Kidney Injury (AKI) is a serious and common complication following heart transplantation, significantly increasing morbidity and mortality. Early and accurate diagnosis of AKI is crucial for timely intervention and improved patient outcomes. However, current diagnostic methods often detect kidney damage only after it has progressed. This study aims to explore Humanin's value as a novel biomarker for early diagnosis and short-term prognosis of AKI after heart transplantation.

This is a planned observational study, and results are not yet available. However, the primary objective is to determine if Humanin concentration can serve as an early diagnostic and prognostic marker for AKI after heart transplantation. Researchers hypothesize that patients who develop AKI will exhibit significantly higher Humanin levels compared to those who do not. The study aims to identify if these differences are statistically significant (e.g., a p-value <0.05 for group comparison) and if Humanin levels correlate with AKI severity or short-term outcomes. The central hypothesis is that elevated Humanin levels will be a strong predictor, potentially showing a >2-fold increase in patients developing AKI, allowing for earlier intervention and improved patient management.