37 studies on Humanin curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This study highlights Humanin-G as a promising therapeutic candidate for septic ARDS, offering a novel approach to protect lung vascular endothelial cells by directly targeting mitochondrial dysfunction. For biohacker…
This research significantly advances our understanding of Humanin's neuroprotective capabilities and its potential as a therapeutic agent for neurodegenerative conditions characterized by oxidative stress, such as Par…
This research highlights HNF14 as a novel and promising therapeutic strategy for Age-related Macular Degeneration, particularly for the atrophic forms where current treatment options are severely limited. Its ability …
The study demonstrated that Humanin treatment significantly improved crucial semen quality parameters. Sperm motility, viability, and membrane integrity were all markedly enhanced compared to untreated controls.
This research highlights humanin's strong potential as a non-invasive, accessible biomarker for early detection and diagnosis of breast cancer. Its high sensitivity and specificity could significantly improve screenin…
This research highlights Humanin's promising role as a novel therapeutic strategy to combat glucocorticoid-induced bone fragility in Duchenne Muscular Dystrophy. By effectively improving both bone density and microarc…
This complete mitogenome sequence provides a foundational genetic resource for Haemaphysalis parva, a species whose vector competence and geographical distribution are not fully understood. The identified unique gene …
This research highlights the potential of Humanin-Like 3 (HN-L3) as a novel, non-invasive biomarker for Multiple Sclerosis (MS), especially in cases with predominant optic nerve and spinal cord involvement. Current di…
This study provides compelling evidence that HNF14, a humanin fragment peptide, holds significant therapeutic potential for Age-related Macular Degeneration. Its ability to simultaneously reduce abnormal blood vessel …
This research provides crucial mechanistic insights into how arsenic, a common environmental contaminant, could contribute to Alzheimer's disease pathology. The findings highlight APP upregulation, NEP downregulation,…
This research highlights Humanin's conserved yet evolutionarily tuned role in protecting against mitochondrial dysfunction and oxidative stress across mammals. The observed species-specific differences provide critica…
The review consistently highlighted that Humanin demonstrated potent and broad-spectrum anti-inflammatory and cytoprotective effects across diverse experimental models. In several mouse models of acute inflammation, H…
This research provides a novel molecular mechanism explaining how the Mediterranean diet may exert its cardioprotective effects, specifically through its influence on mitochondrial microproteins like Humanin and SHMOO…
This study provides compelling evidence that water-based resistance training is a highly effective, accessible, and low-impact intervention for promoting brain health in older adults. The observed improvements in hipp…
This study provides compelling evidence that Humanin-G possesses significant neuroprotective capabilities in a preclinical model of retinal degeneration. The observed preservation of both retinal structure and functio…
Identifying an early and reliable biomarker for AKI after heart transplantation is critically important, as it could enable clinicians to intervene sooner, potentially preventing severe kidney damage and improving pat…
Understanding the precise role of Humanin in the context of cardiac surgery outcomes could significantly advance patient care and risk management. If specific Humanin levels are found to correlate with, or predict, th…
Identifying novel and early biomarkers for Acute Kidney Injury is critically important for improving patient outcomes and guiding therapeutic strategies. If Humanin proves to be a reliable predictive marker, it could …
This research highlights Humanin's significant potential as a novel therapeutic agent for neurodegenerative diseases like Alzheimer's and Parkinson's, as well as other conditions involving mitochondrial dysfunction an…
Understanding the evolutionary history and selective pressures on humanin and SHLP6 provides crucial insights into their functional significance and potential roles in health and disease. The identification of sites u…
This research strongly positions mitochondrial-derived peptides as a novel and potent class of therapeutic agents for the management of Type 2 Diabetes. Their ability to simultaneously improve insulin sensitivity, red…
This research is significant because it reveals that radiation therapy has a systemic impact on mitochondrial-derived peptides, which are crucial for cellular resilience and metabolism. The observed decrease in Humani…
This research is significant as it identifies Humanin and MOTS-c as potential protective agents against chemotherapy-induced reproductive damage. Given the devastating impact of male infertility on cancer survivors, f…
This comprehensive systematic review and meta-analysis solidifies the critical role of Mitochondrial Derived Peptides (MDPs) in metabolic regulation and disease pathogenesis. The consistent and robust correlations obs…
This research significantly advances our understanding of the pleiotropic benefits of SGLT2 inhibitors in diabetic heart failure. By demonstrating their ability to enhance protective mitochondrial peptides and mitigat…
These findings are crucial as they identify multiple novel biomarkers that could potentially aid in the early detection and risk stratification of preeclampsia. Understanding the altered expression of VPO1, humanin, M…
This review underscores the immense therapeutic potential of mitochondria-derived peptides as a novel class of agents for treating cardiovascular diseases. By directly targeting mitochondrial dysfunction, MDPs offer a…
The findings underscore the significant therapeutic potential of mitochondrial-derived peptides as a novel class of agents for preventing and treating vascular aging and associated cardiovascular diseases. By targetin…
This research highlights the immense potential of a novel multi-biomarker panel to revolutionize prostate disease diagnosis and risk stratification. By combining Humanin, GAS5, miR-21, and miR-103, clinicians could ac…
This research highlights the potential of Humanin, Mots-c, and telomere length as novel, non-invasive biomarkers for Alzheimer's disease. Identifying such biomarkers could pave the way for earlier and more accurate di…
This review establishes a crucial link between mitochondrial-derived microproteins and the pathogenesis of both cancer and neurodegenerative diseases, offering a novel perspective on disease etiology. By identifying c…
This review significantly advances our understanding of mitochondria-derived peptides (MDPs) as critical regulators of hepatic metabolism and potential therapeutic agents. The identification of MDPs like MOTS-c and Hu…
This review highlights a significant untapped area of research with profound implications for understanding and treating lung diseases. Given the established roles of MDPs in other complex diseases, their investigatio…
This research provides compelling evidence that MOTS-c and humanin could represent novel therapeutic agents for preventing or treating muscle atrophy, particularly in contexts involving corticosteroid use or other cat…