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mots-c mitochondrial peptide other 2019-08-28 ClinicalTrials

Exercise Program's Impact on Breast Cancer Patients' Body Composition and Activity

Exercise Post-Diagnosis of Breast Cancer

Background

Breast cancer is a prevalent disease, and its treatments often lead to adverse effects like changes in body composition, fatigue, and reduced physical activity. These changes can negatively impact quality of life and long-term prognosis. While exercise is recognized as beneficial, there's a need to understand how structured, longitudinal exercise programs specifically affect body composition and sustained physical activity in breast cancer patients post-diagnosis.

Results

The study aimed to determine if a 12-week exercise program could induce significant changes in body composition among breast cancer patients. Researchers also sought to identify factors that contribute to sustained physical activity beyond the initial intervention period, with follow-up extending for the remainder of the year for Group 1 participants. The primary objective was to quantitatively assess the impact of structured exercise on body composition metrics, such as fat mass and lean muscle mass, in patients recovering from breast cancer treatment. A secondary goal was to evaluate the long-term adherence to physical activity over a 5-year follow-up, comparing the effectiveness of group versus individual exercise settings in promoting sustained engagement. The study design was set to provide crucial preliminary data on the feasibility and potential efficacy of such interventions.

Why It Matters

Understanding the role of exercise in post-diagnosis breast cancer care is crucial for improving patient outcomes and quality of life. If this pilot study demonstrates positive changes in body composition and identifies strategies for sustained physical activity, it could pave the way for integrating structured exercise programs as a standard component of breast cancer survivorship care. This could lead to larger Phase II or Phase III human trials, potentially establishing evidence-based guidelines for exercise interventions that mitigate treatment side effects and improve long-term health for survivors.


mots-c mitochondrial peptide
Source: clinicaltrials:NCT04013568 · Ingested 2026-04-03 · Digest: gemini-2.5-flash