272 studies on Ghrelin mimetic class curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This research provides crucial insights into how major public health crises can influence substance use behaviors, particularly concerning PIEDs. The observed shift towards online procurement and mental health-driven …
This review underscores that zebrafish models provide a cost-effective and high-throughput alternative to traditional mammalian models for early-stage drug discovery and toxicology screening. Their ability to rapidly …
The discovery and characterization of GHS-R3a significantly expands our understanding of the ghrelin system's complexity and evolution in vertebrates. This novel receptor provides new insights into the intricate mecha…
This study provides compelling evidence for hexarelin's potential as a novel therapeutic agent for ischemic heart failure by beneficially modulating the PTEN/Akt/ERK signaling pathway. The observed significant improve…
This research highlights Hexarelin's potential as a therapeutic agent for preventing or treating cardiac hypertrophy, a significant contributor to heart failure and a major public health concern. By demonstrating its …
This research offers a crucial breakthrough in the quest for oral peptide drug delivery, potentially revolutionizing how many chronic conditions are treated. By identifying effective strategies to boost intestinal per…
This research provides compelling evidence that Hexarelin possesses significant anti-atherosclerotic properties by directly interfering with a crucial mechanism of plaque formation: macrophage ox-LDL uptake. Targeting…
This research highlights Hexarelin's potential as a novel therapeutic agent for mitigating the severe damage caused by myocardial ischemia-reperfusion injury. By simultaneously preserving cardiac function and dampenin…
This research highlights a promising therapeutic avenue for obesity and related metabolic disorders by leveraging the body's own growth hormone system. Activating the GHSR could offer a strategy to improve body compos…
This research highlights Hexarelin's significant neuroprotective potential against oxidative stress, a fundamental process implicated in numerous neurodegenerative conditions. By elucidating its mechanism through the …
This research provides compelling evidence that paracellular permeation enhancers can dramatically improve the oral absorption of peptide drugs, potentially paving the way for non-injectable formulations. The substant…
This research highlights Hexarelin's potential as a novel therapeutic agent for abdominal aortic aneurysm (AAA), a life-threatening condition with limited pharmacological treatments. By simultaneously addressing both …
This study provides compelling evidence, supported by cutting-edge imaging, that Hexarelin effectively mitigates cardiac damage and improves heart function after a myocardial infarction. The detailed microstructural i…
This research highlights the significant neuroprotective potential of ghrelin receptor agonists, such as Hexarelin and JMV2894, in mitigating the cellular damage associated with the SOD1-G93A mutation, a key driver of…
This research highlights Hexarelin's potential as a potent neuroprotective agent for conditions involving retinal ganglion cell (RGC) loss. Given the devastating impact of optic neuropathies on vision, finding compoun…
The potent growth hormone-releasing and direct tissue-protective properties of Hexarelin highlight its significant therapeutic potential. Its ability to stimulate GH release could be beneficial for conditions characte…
This study highlights human ghrelin as a promising therapeutic agent for mitigating radiation-induced injury, particularly by protecting the delicate vascular system. The significant improvement in survival rates and …
This seminal research provides a fundamental and detailed understanding of how specific hippocampal subregions, through the precise actions of NMDA receptors, orchestrate distinct aspects of memory formation and retri…
This comprehensive review underscores the critical and urgent need for heightened awareness and proactive management of thrombotic risk in all patients diagnosed with ACTH-dependent Cushing syndrome. Recognizing the s…
This study highlights ghrelin's potential as a novel therapeutic agent for Alzheimer's disease, particularly in patients with co-existing diabetes. By demonstrating ghrelin's ability to suppress Aβ production through …
This review is crucial for consolidating the vast knowledge surrounding ghrelin and identifying critical areas for future research and development. Understanding ghrelin's diverse physiological roles and the hurdles t…
This study provides crucial evidence of the ongoing misuse of GHRP-2 and GHRP-6 in sports and validates a robust analytical method for their detection. The ability to accurately identify these peptides in athlete urin…
The prevalence of NAFLD and NASH is alarmingly high, and effective pharmacological treatments are scarce, making the exploration of new therapies critical. Positive findings from this pilot study could position Ibutam…
This research uncovers a novel and crucial gut-brain-liver axis where gut-derived ghrelin plays a pivotal role in the systemic regulation of glucose metabolism. Understanding this intricate pathway provides significan…
This study highlights the significant metabolic benefits of a linear fragment of unacylated ghrelin (UAG-LF), particularly its ability to improve insulin sensitivity and reduce hepatic steatosis in an obese model. The…
This research uncovers a previously unknown direct link between ghrelin and oxytocin, suggesting that ghrelin's influence extends beyond appetite regulation to potentially impact broader metabolic and behavioral pathw…
This study provides compelling evidence that both Ghrelin and LHA electrical stimulation can effectively normalize the pathological hyperactivity of gastric distention neurons in a cisplatin-induced gastric dysfunctio…
This research highlights a novel strategy for overcoming acquired drug resistance in lung cancer, a major clinical challenge. By targeting the ghrelin receptor, this study demonstrates a potential pathway to re-sensit…
This research provides critical new insights into ghrelin's direct role in regulating pancreatic islet microcirculation, a process fundamental for maintaining islet health and optimal insulin production. Understanding…
This research highlights Acylated Ghrelin as a promising therapeutic agent to prevent or reduce doxorubicin-induced cardiotoxicity. By targeting the Fas/FasL apoptotic pathway and enhancing SERCA2a activity, it offers…
This study provides compelling evidence that Ghrelin/GHSR signaling plays a crucial role in protecting hippocampal neurogenesis from chronic stress-induced damage, leading to improved mood-related behaviors. This sugg…
This research provides crucial insights into the cellular mechanisms governing gut motility, specifically how key hormones like ghrelin and motilin regulate the electrical activity of ICCs. Understanding these pathway…
These findings are highly significant as they demonstrate that Ghrelin acts as a potent neuroprotective agent against HIE-induced brain injury by modulating oxidative stress and neuronal apoptosis. The elucidation of …
This research provides compelling evidence that ghrelin plays a previously unrecognized role in promoting cartilage anabolism by activating the ERK/STAT3 pathway in AIS chondrocytes. This finding is significant becaus…
This study highlights that GHSR signaling can directly influence high-fat food intake in a binge eating context, independent of circulating ghrelin and LEAP2 levels. This suggests a novel, direct role for GHSR in the …
This research highlights a novel pathway for treating alcoholic hepatic steatosis, a critical precursor to more severe alcoholic liver disease. The findings suggest that ghrelin receptor antagonism could be a promisin…
This research uncovers a novel and critical brain-gut axis involving ghrelin that directly regulates glycolipid metabolism, providing a deeper understanding of how the brain controls energy homeostasis. The identifica…
This research highlights ghrelin as a promising therapeutic candidate for addressing cognitive impairment associated with diabetes and potentially Alzheimer's disease. The ability of ghrelin to modulate the IKK/NF-κB/…
This research identifies a novel regulatory pathway where miR-709 acts as a crucial negative regulator of GHRP6-induced GH synthesis by targeting PRKCA. This discovery provides a deeper understanding of the complex me…
This research highlights a critical mechanism by which estradiol replacement therapy can combat post-menopausal obesity by directly modulating the ghrelin pathway. Understanding this interaction provides a novel thera…
This research highlights a novel neuro-gastrointestinal pathway where central ghrelin signaling can protect the gut barrier from inflammatory insults. The findings suggest that targeting ghrelin receptors in the brain…
This research highlights a significant potential side effect of D-Lys-3-GHRP-6, indicating it may negatively impact cognitive functions, specifically memory consolidation. The observed downregulation of serotonin and …