Thermal and pH Stress Impact Growth Hormone Releasing Hexapeptide Stability
Mass spectrometric and kinetics characterization of modified species of Growth Hormone Releasing Hexapeptide generated under thermal stress in different pH and buffers.
Background
Growth Hormone Releasing Hexapeptide (GHRP-6) is a synthetic peptide known to stimulate growth hormone release, crucial for muscle growth and tissue repair. Its therapeutic potential for conditions like growth hormone deficiency and sarcopenia depends on its stability. This study addresses the critical knowledge gap regarding the specific degradation pathways and kinetics of Growth Hormone Releasing Hexapeptide under varied thermal and pH conditions, essential for its pharmaceutical development.