149 studies on Growth factor class curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This research establishes IGF-1 deficiency as a crucial, previously underappreciated factor in the pathogenesis and prediction of Poor Ovarian Response. The findings suggest that routine screening for IGF-1 levels cou…
This study underscores the significant impact of modifiable lifestyle factors on IGF-1 levels and subsequent breast cancer risk, particularly within vulnerable populations like Palestinian women in the Gaza Strip. The…
This research highlights a novel mechanism by which diabetes exacerbates coronary artery disease, specifically through its detrimental effects on lymphatic vessel formation and function in the fat surrounding the hear…
This research identifies MLPH as a novel and potent regulator of human hair growth, acting directly on the critical IGF-1 signaling pathway within the dermal papilla. Understanding this mechanism provides a new therap…
This synthesis of evidence underscores the critical role of growth hormone (GH) in driving breast cancer progression, metastasis, and angiogenesis, moving beyond the traditional focus on steroid hormones. Understandin…
This research highlights a critical, previously underappreciated mechanism by which androgenic anabolic steroid (AAS) use may exert its adverse health effects. The disruption of the IGF-PAPP-A-stanniocalcin axis could…
This study represents a significant advancement in standardizing IGF-1 measurement, which is absolutely critical for accurate diagnosis and effective monitoring of endocrine disorders. The enhanced precision, accuracy…
This comprehensive review highlights the critical role of IGF-1 in MASLD pathogenesis, suggesting it's not just a correlative factor but potentially a key player. The most significant implication is that IGF-1 levels …
This study provides compelling evidence that combining BoNT-A with CIMT offers a synergistic approach to not only improve motor function but also actively promote skeletal muscle regeneration in hemiplegic cerebral pa…
This research suggests that tripeptide-copper complex could be a potent new agent for treating hair loss by directly stimulating hair follicle cells and upregulating critical growth factors. Its ability to promote cel…
This research fundamentally shifts our understanding of IGF-1's role in aging, proposing a biphasic model that moves beyond simple 'more is better' or 'less is better' paradigms. The identification of an IGF-1 senesce…
Understanding how different exercise types acutely impact cerebral blood flow is crucial for developing targeted interventions to maintain cognitive function in healthy aging. If this study demonstrates significant im…
The development of effective and safe strategies for rapid weight loss in severe obesity is crucial for improving patient health and preparing for bariatric surgery or other long-term interventions. If the results of …
The establishment of accurate normative ranges for IGF-1, IGFBP-3, and ALS is profoundly important for pediatric endocrinology. These reference values provide clinicians with the necessary tools to differentiate betwe…
This global registry represents a crucial step in understanding the long-term safety and effectiveness of Increlex® for SPIGFD. By collecting data from a large, diverse patient population over many years, it can ident…
If successful, this research could provide a non-pharmacological strategy to mitigate breast cancer risk in individuals with BRCA mutations. Understanding the impact of diet on biomarkers like IGF-I could empower muta…
The demonstration of safety and feasibility for the Fasting Mimicking Diet (FMD) in cancer patients is a significant step, as it suggests that this non-pharmacological intervention could be safely integrated into exis…
This study provides crucial insights into the cellular mechanisms underlying the FecB mutation's prolificacy effect, demonstrating that ovarian cells from carriers are inherently more responsive to key fertility signa…
This research provides novel and critical mechanistic insights into how IGFBP-3 modulates cellular responses to growth factors, unequivocally identifying sphingosine kinase as a pivotal downstream effector in this pro…
This research highlights ALK4/5 inhibition as a highly promising therapeutic strategy for cancer cachexia, a condition with limited treatment options. By targeting a key pathway involved in muscle degradation, this ap…
This research provides compelling evidence that recombinant IGF-1 can induce targeted organ growth, rather than generalized, uncontrolled proliferation, in a developing fetus. This specificity is critical, as it sugge…
This research provides compelling evidence that GH and IGF-I can effectively counteract the decline in milk production during prolonged lactation, suggesting new avenues for intervention. The distinct yet complementar…
This research provides a fundamental understanding of how estradiol promotes muscle stem cell proliferation, highlighting the Epidermal Growth Factor Receptor (EGFR) as a critical mediator. Understanding this pathway …
This research provides critical insights into the intricate mechanisms governing coordinated cardiac and vascular development, particularly during vulnerable fetal stages. Understanding how IGF-1 orchestrates this bal…
This research provides compelling evidence that sustained elevated IGF-1 during fetal development directly programs pancreatic beta-cell dysfunction, leading to reduced glucose-stimulated insulin secretion. This is a …
This research highlights the fundamental importance of N-linked glycosylation for optimal IGF-1 signaling, providing crucial insights into cell biology and receptor function. Given that CHO cells are the primary indus…
This research highlights a complex interplay between IGF-1 and fetal glucose metabolism, suggesting that the in vivo effects of IGF-1 LR3 on insulin secretion are not solely due to direct actions on pancreatic beta ce…
This research highlights a critical insight into Alzheimer's disease pathology, suggesting that interventions solely focused on modifying amyloid plaques may not always translate into tangible cognitive benefits. The …
This study suggests that IGF-1 LR3 may not be an effective therapeutic strategy for reversing late-gestation intrauterine growth restriction (IUGR), even when systemic levels of IGF-1 are significantly elevated. The f…
This research introduces a highly innovative, sustainable, and biologically active nerve conduit derived from a plant source, offering a compelling alternative to current nerve repair strategies. The successful integr…
This research highlights a highly promising therapeutic strategy for treating volumetric muscle loss, a condition with limited effective treatments. By demonstrating that localized and sustained delivery of IGF-1 via …
This Phase 4 study is significant because it investigates a sequential therapy approach for Thyroid Associated Ophthalmopathies (TAO), a debilitating condition often resistant to current treatments. IBI311, as an anti…
Understanding the role of post-exercise protein in bone health could significantly impact recovery protocols for endurance runners and other athletes, potentially reducing the risk of stress fractures and osteoporosis…
This research is critical for understanding the molecular mechanisms behind skin aging and its response to environmental stressors like UVB. If Insulin-Like Growth Factor 1 proves effective in modulating gene expressi…
These findings highlight capsaicin as a promising therapeutic candidate for managing insulin resistance-induced prostatic hyperplasia, offering a natural compound approach to a widespread health issue. By modulating I…
The findings suggest that IGF-1 supplementation could be a safe and effective strategy for preventing severe ROP in extremely premature infants, potentially mitigating the devastating visual outcomes associated with t…
This research highlights a novel mechanistic link between Aβ pathology, IGF1R nuclear signaling, and aberrant cell cycle re-entry in Alzheimer's disease. Understanding this pathway could open new avenues for therapeut…
This research provides crucial mechanistic insights into how Electrical Muscle Stimulation (EMS) combats denervated muscle atrophy following brachial plexus injury. By demonstrating the involvement of the Cav1.1-Ca2+-…
This discovery of RGC-NRE1 provides a powerful tool for precisely targeting gene expression to retinal ganglion cells, which is a critical advancement for ocular gene therapy. By enabling highly specific delivery of n…
This research highlights the critical role of PTN/IGF-2 signaling in orchestrating the complex processes of endometrial decidualization and immune modulation essential for successful pregnancy. The findings suggest th…
This research highlights CCN5/WISP2 as a critical regulator of muscle homeostasis, acting both intracellularly and as a secreted factor to combat muscle wasting. The findings suggest that targeting CCN5/WISP2 pathways…
If GHRH were found to be effective, this research could pave the way for a novel therapeutic strategy to address age-related sleep disturbances, a widespread issue affecting millions. Successfully augmenting the GH-IG…
These findings suggest that GHRH therapy could represent a novel therapeutic strategy for improving cardiac function and quality of life in older adults with congestive heart failure and reduced growth hormone effect.…
This study provides compelling evidence that tesamorelin could be a highly effective pharmacological intervention for MASLD, addressing a critical unmet medical need. The significant reduction in liver fat observed su…