Immune Cell Imbalance Linked to Depression in CVID Patients; Thymosin-α1 Proposed.
Reduced numbers of naïve CD4 + T cells and an altered CD4/CD8 balance in depressed common variable immune deficiency (CVID) patients. Is thymosin-α1 a possible treatment?
Background
Common Variable Immune Deficiency (CVID) is a primary immunodeficiency causing impaired antibody production, leading to recurrent infections and autoimmune issues. Patients with CVID frequently experience depression, but the underlying immunological links are poorly understood. This study investigated specific immune cell profiles in depressed CVID patients to identify potential therapeutic targets.
