New Trial Investigates Dual Therapy for Post-Surgery Complications in Aortic Dissection

Acute Aortic Syndrome (AAS) and subsequent acute aortic dissection surgery frequently lead to severe post-operative complications, notably Systemic Inflammatory Response Syndrome (SIRS) and Multiple Organ Dysfunction Syndrome (MODS), which are primary drivers of mortality. While anti-inflammatory treatments exist, there remains a critical knowledge gap in effectively preventing these immune-mediated systemic dysfunctions. This PANDA XI study aims to determine if combining the anti-inflammatory agent Ulinastatin with the immunomodulatory peptide Thymosin α1 can significantly reduce the incidence of SIRS and MODS after AAS surgery.