142 studies on Other class curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This study provides compelling mechanistic evidence that ARA290 can effectively protect against cisplatin-induced nephrotoxicity by simultaneously suppressing apoptosis and inflammation. The ability of ARA290 to targe…
This research introduces a potentially groundbreaking therapeutic strategy for combating age-related cardiovascular diseases. By utilizing a small erythropoietin-derived non-hematopoietic peptide, the study successful…
This research is highly significant as it identifies a novel and effective therapeutic strategy for combating age-related diseases and potentially extending healthy lifespan. By specifically targeting the FOXO4-p53 in…
This study provides compelling evidence that targeting cellular senescence with Fisetin can effectively mitigate and even reverse age-related and disease-induced kidney dysfunction. The ability to significantly improv…
This research highlights a novel therapeutic strategy for keloids by precisely targeting senescent fibroblasts and their inherent resistance to apoptosis. By modulating p53 activity and promoting its nuclear exclusion…
This research highlights FOXO4-DRI as a potent anti-senolytic agent, capable of rejuvenating endothelial cells and improving vascular health by modulating the P53 pathway. The ability to reverse cellular aging in the …
Understanding the interaction between dexmedetomidine and orexin A could provide crucial insights into the neurobiology of anesthetic emergence and recovery. If a significant correlation or causal link is established,…
Understanding the genetic and clinical heterogeneity of narcolepsy across diverse ethnic groups is crucial for improving diagnosis and personalized treatment strategies. This research could lead to the identification …
While this specific study yielded no data due to its withdrawal, the underlying research question remains highly relevant. Understanding interventions that could improve family interactions is critical for supporting …
Postpartum depression carries grave consequences for maternal-infant bonding and childhood psychological development, making early identification critical. If prenatal oxytocin levels are confirmed as a reliable bioma…
This research is profoundly significant because it provides compelling ex vivo evidence for PNC-27's potent anti-cancer activity in a highly relevant model using actual human patient samples. This approach offers a mo…
This research highlights PNC-27 as a promising dual-mechanism anti-cancer agent that targets both an intracellular protein (HDM-2) and the cell membrane. Its selective toxicity towards cancer cells, while sparing norm…
This study provides crucial insights into the molecular mechanisms governing the stability and efficacy of p53-derived anticancer peptides, highlighting the critical role of the ETFS amino acid sequence. The findings …
This research is highly significant because it establishes a robust, efficient, and scalable method for producing a modified Delta Sleep-Inducing Peptide (DSIP) with enhanced pharmacokinetic properties. The successful…
The study found that p-DSIP treatment significantly improved sleep architecture in high-altitude exposed rats, leading to a marked increase in non-rapid eye movement (NREM) sleep duration and a significant reduction i…
This research significantly advances our understanding of the fundamental molecular mechanisms underlying precise neural circuit formation. By identifying DIP-α and Dpr10 as key transsynaptic organizers, the study pro…
This research represents a significant advancement in sustainable peptide chemistry, providing a greener and more efficient route for producing peptide pharmaceuticals and biomaterials. By drastically reducing chemica…
This study is significant because it could establish Adrenomedullin as a crucial biomarker for Acute Myeloid Leukemia prognosis and treatment response. If Adrenomedullin levels accurately reflect disease burden and pr…
The findings from this randomized controlled trial are crucial for optimizing the management of prelabor rupture of membranes at term, a condition that impacts thousands of pregnancies annually. If immediate oxytocin …
The exploration of ARA 290, a non-hematopoietic erythropoietin analogue, holds significant promise as it targets a novel mechanism for glucose regulation, potentially offering a new therapeutic avenue beyond existing …
If the study's hypothesis of a positive shift in emotional processing was confirmed, it would represent a significant step forward in neuroscience and psychopharmacology. This could establish ARA290 as a promising can…
This research introduces a sustainable and highly efficient method for extracting honeybee venom proteins, potentially unlocking their full therapeutic potential by ensuring higher yields and better preservation of bi…
This research highlights IL-3/CD123 signaling as a novel and potent regulator of microglial function, offering a promising therapeutic target for neuroinflammatory diseases and cognitive disorders. By modulating this …
Understanding the exact chemical structure and properties of Orexin B is absolutely fundamental for advancing research into its biological roles and for rational drug design and development. This detailed molecular pr…
The PubChem profile unequivocally identifies Orexin A through its unique Compound ID (CID): 56842143, a standard identifier in chemical databases. It precisely outlines the peptide's complex molecular formula as C152H…
The characterization of Pinealon as a neuroprotective tripeptide is highly significant, as it points towards a potential endogenous mechanism for maintaining brain health and resilience. This understanding could be fo…
This study provides compelling evidence that FOXO4-DRI effectively clears senescent cells and mitigates multiple hallmarks of aging in a preclinical model. The observed improvements in physical function and metabolic …
The potential significance of PNC-27 remains entirely theoretical without empirical data on its biological interactions. Its intricate peptide structure suggests it could potentially interact with various biological t…
This study provides strong preclinical evidence for a novel therapeutic approach to combat brain aging and cognitive decline by targeting the FOXO4-p53 axis. The significant improvements in cognitive function and redu…
This research unveils a highly innovative peptide-based platform that not only possesses intrinsic antioxidant properties but also incorporates a sophisticated, ROS-responsive mechanism. The remarkable ability of the …
This research provides crucial insights into the structure-activity relationships of antimicrobial peptides, highlighting the importance of specific amino acid modifications for combating multidrug-resistant bacteria.…
This research highlights scyreprocin's significant potential as a new therapeutic agent against challenging MDR bacterial infections, offering a much-needed alternative to failing conventional antibiotics. Its low pro…
This study provides a robust and rapid platform for producing high-quality, functional bovine interferon-gamma, which is critical for advancing veterinary research and diagnostics. The ability to quickly generate larg…
This study highlights the significant potential of NRP1-PDC as a dual-action therapeutic strategy for highly aggressive cancers like glioblastoma. By simultaneously targeting tumor cells and their blood supply through…
This research provides critical foundational data for developing PULMO-Modulin as a potential inhaled therapeutic for pulmonary diseases where cAMP modulation is beneficial, such as asthma or COPD. The favorable bioph…
This research presents a highly promising non-invasive oral strategy for managing sepsis, leveraging a dual-agent approach to target both inflammation and potential microbial components. The use of pH-responsive micro…
This research represents a significant step forward in developing advanced tools for copper ion detection in complex biological matrices. The ability of these Uracil-Peptide-Pyrene conjugates to act as Cu2+-sensitive …
This research provides compelling preclinical evidence that thrombopoietin receptor agonists could offer a targeted and effective therapeutic strategy for MYH9-RD, a rare disease with significant unmet medical needs. …
This research highlights the potential of chirality-converted bacteriolytic peptides as a promising new class of antimicrobials that can effectively target pathogens without causing widespread disruption to beneficial…
This study demonstrates a highly effective strategy for the rapid discovery of potent VHH therapeutics against emerging viruses, highlighting the significant potential of VHH-VEEV-001 as a lead candidate for VEEV. The…
This research represents a significant advancement by identifying a novel class of macrocyclic peptides that specifically target the oncogenic RhoA G17V mutation. The high specificity and potent in vitro inhibitory ac…
This study highlights the critical need for careful monitoring of bone health in patients on long-term PTH(1-34) therapy for hypoparathyroidism. The findings suggest that while effective in managing calcium levels, pr…
This research represents a significant step forward in developing more effective opioid peptide-based analgesics. By enhancing hydrophobicity and plasma stability, these modified Endomorphin-1 derivatives possess impr…
This research presents a groundbreaking approach to antithrombotic therapy, offering a potential solution to the long-standing challenge of balancing efficacy with safety. The ability to uncouple antithrombosis from b…