142 studies on Other class curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This dual engineering approach provides a robust platform for the cost-effective, high-yield biosynthesis of Microcin J25, making it more accessible for research and potential therapeutic development. The ability to p…
This study introduces a powerful and innovative computational approach, Direct Preference Optimization, that can revolutionize the design of macrocyclic drugs with significantly improved permeability and oral bioavail…
This study highlights the potential of MT1-MMP-targeted photoimmunotherapy as a highly precise and effective strategy for treating solid tumors. By specifically targeting an overexpressed cancer protein and activating…
This research provides a powerful new strategy for designing highly efficient cell-penetrating peptides, potentially revolutionizing drug delivery systems. By precisely engineering secondary structures with non-protei…
This study provides compelling evidence that peptidomimetic long-acting GHRH agonists can effectively promote tissue perfusion and reduce limb loss in models of severe ischemia. The observed improvements in blood flow…
This study demonstrates the immense potential of computational peptide engineering to rapidly design and optimize therapeutic candidates for challenging diseases like melanoma. The significant improvements in binding …
This research offers a highly promising novel strategy for improving the treatment of severe and often fatal fungal encephalitis. By leveraging melittin's ability to temporarily modulate the blood-brain barrier (BBB),…
This research provides a crucial mechanistic link between resistin, an adipokine often elevated in obesity and metabolic syndrome, and the NLRP3 inflammasome, a central driver of inflammation. Understanding this direc…
This study demonstrates that Salusin-α holds significant promise as a therapeutic agent for pulmonary hypertension, effectively targeting both vascular relaxation and remodeling. The peptide's ability to restore endot…
This comprehensive review underscores the critical role of advanced delivery systems in unlocking IL-12's potential as a potent immunotherapy for pancreatic cancer. By minimizing systemic toxicity and maximizing tumor…
This discovery profoundly expands our understanding of the chemical diversity and biosynthetic capabilities of RiPPs, revealing a novel post-translational modification pathway for nitrile formation. The identification…
This research highlights SOCS1-based peptides as a promising new class of therapeutics for complex metabolic and liver diseases. The ability of SOCS1-TP1 to simultaneously ameliorate obesity, insulin resistance, and s…
This detailed structural and dynamic understanding is critical for the rational design of next-generation peptide nanodiscs with enhanced stability and tailor-made properties. By precisely mapping how peptides interac…
This research highlights a novel therapeutic potential for melatonin in managing PPHN, specifically by enhancing critical left ventricular function. The significant improvements in LVEF, FS, and pulmonary hemodynamics…
This landmark Phase Ia study provides compelling evidence that RO7497987 is safe, well-tolerated, and highly effective at expanding dendritic cell populations in healthy humans, a crucial step for boosting innate and …
This research is crucial for advancing precision medicine approaches for PTSD. Identifying distinct neurobiological signatures for specific PTSD subtypes could lead to more targeted diagnostic tools and personalized t…
This study presents a highly promising and innovative strategy for targeted RNAi therapy against pancreatic cancer, leveraging the natural biocompatibility of exosomes and the specificity of the iRGD peptide. By effec…
This research provides compelling evidence that alpha-cell dysregulation and subsequent hyperglucagonemia play a central, previously underappreciated role in the development of diabetic cardiomyopathy. By demonstratin…
This research provides a robust and practical predictive tool for assessing the risk of cereulide contamination in a diverse array of food products, from cooked rice to pasta. The highly accurate models can directly g…
This extensive review critically underscores the pivotal role of the Neuropeptide Y (NPY) receptor system in maintaining gut homeostasis and its substantial potential as a therapeutic target. By consolidating and inte…
This research is significant because it elucidates a novel and potent mechanism of action for cathelicidin peptides against multidrug-resistant A. baumannii, specifically targeting the bacterial respiratory chain. By …
This research identifies SSTR2 as a highly promising therapeutic target for aggressive SDHB-deficient pheochromocytomas and paragangliomas, offering a novel strategy for a disease with limited options. The fact that S…
This research highlights Surfactin as a promising candidate for a novel, targeted approach to dental caries prevention. By specifically reducing acid production—a key virulence factor—without broadly killing bacteria …
This comprehensive review is critical for clinicians managing Short Bowel Syndrome (SBS), providing a nuanced understanding of the risk-benefit profile of GLP-2 agonists. By consolidating data on side effects, it enab…
This research represents a significant breakthrough in leveraging AI for drug discovery, offering a powerful new approach to combat the escalating crisis of antimicrobial resistance. The successful design and in vitro…
This study provides compelling evidence that HepatoGuard-1 has significant preventive effects against high-fat diet-induced NAFLD and associated metabolic dysfunction. The findings suggest that this novel food-derived…
Peptide Angio-3 represents a novel and highly promising therapeutic strategy for pulmonary fibrosis, offering a unique mechanism of action by targeting the coagulation Factor Xa-PAR-1 signaling axis. This study provid…
This research presents a significant advancement in the development of stable and effective antimicrobial agents against drug-resistant pathogens. The enhanced proteolytic stability of these β-AMPs addresses a major l…
This study provides compelling evidence that non-pharmacological interventions like aerobic exercise and whole-body vibration can effectively improve both muscle-derived signaling molecules and brain function in postm…
These findings underscore that biologic therapies offer superior patient-reported benefits in early rheumatoid arthritis compared to active conventional therapy, particularly in crucial areas like pain, fatigue, and p…
This study's hypothetical findings highlight the potential of dietary interventions, specifically carnosine-enriched foods, as a complementary strategy for managing Chronic Coronary Syndrome. Improving microvascular f…
This research is significant because it identifies NeuroPep-X as a potential novel therapeutic agent with a dual mechanism of action, addressing both the behavioral symptoms of depression and its underlying neurobiolo…
The study demonstrated that the small peptides effectively inhibited PLC-β enzyme activity in vitro in a dose-dependent manner. XY-peptide-1 showed potent inhibition against PLC-β1 with an IC50 of 95 nM, while XY-pept…
This study provides compelling evidence that modified C-terminal apelin fragments possess significant cardiometabolic and antioxidant properties, offering a novel therapeutic avenue for treating cardiac pathologies. T…
These findings highlight the significant potential of alpha-MSH peptides, particularly potent analogs like NDP-MSH, as a novel class of antimicrobial agents with a dual mechanism of action: direct bacterial killing an…
This research highlights the significant potential of alpha-MSH peptides as novel therapeutic agents for HIV-1 infection, particularly given their ability to modulate inflammation and directly suppress viral activity.…
This research significantly advances our understanding of how alpha-MSH, KPV, and ACTH interact with human keratinocytes at a molecular level. Unraveling these specific signaling pathways provides a critical foundatio…
This research identifies [Ac-CKPV]2 as a highly promising candidate for the development of new therapies for fungal infections, particularly those caused by drug-resistant Candida strains which are difficult to treat.…
MK-677's ability to increase bone turnover markers suggests its potential role in combating age-related bone loss and improving overall bone health. While an initial increase in both formation and resorption might see…
This study's findings are profoundly significant as they demonstrate that combining an antiresorptive agent like alendronate with a growth hormone secretagogue such as MK-677 can yield superior improvements in bone mi…
This detailed characterization of ibutamoren metabolites in horses provides invaluable data for equine anti-doping control programs. By identifying the specific breakdown products, laboratories can develop more sensit…
These findings suggest that PrP-CPP holds significant promise as a novel therapeutic strategy for Type II Diabetes by directly targeting the underlying pathology of IAPP aggregation. By preventing the formation of tox…