188 studies on Mitochondrial peptide class curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This study highlights MOTS-c as a crucial mediator of the cardioprotective effects of aerobic exercise in diabetic myocardial injury, primarily through enhancing antioxidant defense. The findings suggest that targetin…
This research highlights the significant therapeutic potential of MOTS-c as a novel intervention for myocardial infarction, offering a promising strategy beyond conventional treatments. By targeting mitochondrial func…
This study provides compelling evidence that MOTS-c peptide could be a novel and effective therapeutic agent for diabetic cardiomyopathy. Its ability to improve cardiac function, reduce fibrosis, and mitigate oxidativ…
This research strongly positions mitochondrial-derived peptides as a novel and potent class of therapeutic agents for the management of Type 2 Diabetes. Their ability to simultaneously improve insulin sensitivity, red…
This research highlights MOTS-c as a promising therapeutic agent for combating muscle wasting and associated fat infiltration caused by immobilization. The ability of MOTS-c to simultaneously preserve muscle mass and …
This research highlights MOTS-c as a novel and potent regulator of NASH progression, acting through a direct interaction with Bcl-2 to mitigate hepatic steatosis, inflammation, and fibrosis. The findings underscore th…
This research is significant because it reveals that radiation therapy has a systemic impact on mitochondrial-derived peptides, which are crucial for cellular resilience and metabolism. The observed decrease in Humani…
This research identifies DNA-PKcs as a critical driver of myocardial microvascular injury during sepsis, highlighting it as a promising therapeutic target. The findings also underscore the protective role of MOTS-c, s…
This study provides crucial in vitro evidence for the direct regulatory role of MOTS-c on pancreatic islet cells, suggesting its potential as a therapeutic agent for metabolic disorders. By simultaneously improving in…
This study provides compelling and novel evidence that central MOTS-c administration can significantly modulate reproductive hormones, with distinct effects depending on the metabolic state of the individual. The abil…
This research provides compelling evidence that MOTS-c offers significant protection against formyl peptide-induced acute lung injury by inhibiting FPR2-mediated ferroptosis and preserving endothelial barrier function…
This study underscores the critical role of mitochondrial MOTS-c (a mitochondrial-derived peptide involved in metabolic regulation) as a key mediator of exercise's beneficial effects on diabetes. The findings suggest …
This research provides compelling evidence that mitochondria-derived peptides represent a novel and promising therapeutic strategy for treating painful diabetic neuropathy. By directly targeting mitochondrial dysfunct…
The study unequivocally revealed a significant and consistent association between markers of mitochondrial dysfunction and poorer cognitive performance across several critical domains in adults with OSA. Specifically,…
This study identifies MOTS-c as a promising novel therapeutic agent for cancer-induced bone pain, addressing a significant unmet medical need in oncology. Its unique mechanism through AMPK-mediated mitochondrial bioge…
This groundbreaking research highlights MOTS-c as a highly promising novel therapeutic agent for the prevention and treatment of radiation pneumonitis. Its ability to simultaneously modulate inflammation, reduce oxida…
This study provides a robust mechanistic framework for understanding how MOTS-c protects the brain after traumatic injury, highlighting its role in enhancing mitochondrial function and reducing inflammation and oxidat…
This research is significant as it identifies Humanin and MOTS-c as potential protective agents against chemotherapy-induced reproductive damage. Given the devastating impact of male infertility on cancer survivors, f…
This research highlights MOTS-c as a promising, novel biomarker that can significantly refine risk prediction for mortality and cardiovascular events in chronic hemodialysis patients. Identifying high-risk individuals…
This comprehensive systematic review and meta-analysis solidifies the critical role of Mitochondrial Derived Peptides (MDPs) in metabolic regulation and disease pathogenesis. The consistent and robust correlations obs…
This research significantly advances our understanding of the pleiotropic benefits of SGLT2 inhibitors in diabetic heart failure. By demonstrating their ability to enhance protective mitochondrial peptides and mitigat…
This research highlights Pyrroloquinoline Quinone (PQQ) as a promising therapeutic agent for mitigating radiation-induced lung injury (RILI), a debilitating side effect of cancer radiotherapy. By demonstrating PQQ's a…
Understanding the role of MOTS-c in facilitating plasma membrane repair opens new avenues for therapeutic strategies. Given that cellular membrane damage is a fundamental component of numerous diseases and injuries, m…
This research positions MOTS-c as a novel and highly promising therapeutic candidate for ovarian cancer, offering a new avenue for treatment. By specifically targeting the USP7-LARS1 pathway, MOTS-c introduces a disti…
This research highlights the critical role of genetic predispositions, specifically the MOTS-c K14Q polymorphism, in age-related health decline. Understanding this genetic link could pave the way for personalized medi…
This research highlights MOTS-c's potential as a novel therapeutic agent to enhance the efficacy of existing cancer treatments by overcoming drug resistance, particularly in challenging tumor microenvironments like hy…
These findings are crucial as they identify multiple novel biomarkers that could potentially aid in the early detection and risk stratification of preeclampsia. Understanding the altered expression of VPO1, humanin, M…
This research provides a novel mechanistic understanding of how endurance training improves skeletal muscle mitochondrial function, highlighting MOTS-c as a key player. The findings suggest that circulating MOTS-c lev…
This research highlights MOTS-c as a promising, non-invasive biomarker for the early detection of Diabetic Kidney Disease (DKD) in children with Type 1 Diabetes Mellitus. Identifying DKD earlier could enable more time…
The most significant finding was that MOTS-c administration achieved comparable or superior protective effects to remote ischemic preconditioning in mitigating lung ischemia-reperfusion injury, reducing tissue damage …
This research significantly advances our understanding of MOTS-c as a potent regulator of muscle development and metabolism, highlighting its potential to improve muscle health across different fiber types. The findin…
This research highlights MOTS-c as a promising novel therapeutic candidate for age-related macular degeneration (AMD), addressing the critical need for treatments that target the underlying mitochondrial dysfunction. …
This pilot study positions MOTS-c as a promising novel biomarker for identifying chronic peritoneal dialysis patients at an elevated risk for sarcopenia. Early detection of sarcopenia through such a biomarker could fa…
This research is crucial for understanding the pleiotropic effects (multiple beneficial actions beyond the primary one) of GLP-1RAs and SGLT-2is in diabetes. By elucidating their impact on neurohumoral and mitochondri…
This research highlights MOTS-c as a promising novel therapeutic agent for preventing or treating CPB-induced acute lung injury. By promoting glycolysis through the AMPK-HIF-1α-PFKFB3 pathway, MOTS-c offers a unique m…
This review underscores the immense therapeutic potential of mitochondria-derived peptides as a novel class of agents for treating cardiovascular diseases. By directly targeting mitochondrial dysfunction, MDPs offer a…
Circulating PGC-1α and MOTS-c could serve as novel, non-invasive biomarkers for assessing mitochondrial health, predicting post-operative complications, and stratifying risk in AVR patients. This could enable earlier …
This research highlights MOTS-c's significant potential as a valuable new tool for the early diagnosis and improved management of Myocardial Infarction. Its ability to provide rapid and accurate diagnostic information…
This study provides compelling evidence that MOTS-c offers a robust protective effect against lung ischemia-reperfusion injury through a novel MYH9-dependent mechanism. The identification of MYH9 as a key mediator lin…
This study highlights MOTS-c as a promising therapeutic agent that can effectively combat diabetic liver fibrosis by mimicking the beneficial effects of exercise. Its ability to modulate key anti-fibrotic and antioxid…
The identification of these circulating mitochondrial biomarkers represents a significant advancement in the diagnostic landscape for Acute Coronary Syndrome. These novel markers could enable earlier and more accurate…
This research highlights MOTS-c as a promising novel therapeutic agent for allergic asthma, offering a unique approach by targeting a fundamental aspect of the disease: airway barrier dysfunction and epithelial apopto…
This research provides a critical mechanistic link between maternal obesity and the multigenerational inheritance of MASLD, highlighting mitochondrial dysfunction as a key driver. Understanding this pathway opens new …
This research highlights the significant potential of MOTS-c-modified peptide hydrogels as a novel therapeutic strategy for intervertebral disc degeneration. By enhancing the activity and survival of NP-MSCs, this app…
This study provides novel insights by identifying reduced MOTS-c levels as a potential characteristic of obstructive sleep apnea patients. Given MOTS-c's established role in metabolic health and cellular resilience, t…
The findings underscore the significant therapeutic potential of mitochondrial-derived peptides as a novel class of agents for preventing and treating vascular aging and associated cardiovascular diseases. By targetin…