188 studies on Mitochondrial peptide class curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
These findings highlight MOTS-c as a highly promising therapeutic candidate for treating diabetic cardiomyopathy by directly addressing the underlying mitochondrial dysfunction. The ability of MOTS-c to restore fundam…
This research is significant because it suggests that repeated heat stress could serve as a non-pharmacological intervention to influence metabolic and muscular health, particularly during periods of muscle disuse or …
This review significantly advances our understanding of Parkinson's disease by highlighting the previously underappreciated role of mitochondria-derived microproteins (MDPs) as key players in its pathogenesis. The fin…
This research highlights MOTS-c as a promising therapeutic candidate for mitigating sepsis-associated brain injury by directly targeting the blood-brain barrier. The ability of MOTS-c to preserve BBB integrity and red…
This research highlights the immense potential of a novel multi-biomarker panel to revolutionize prostate disease diagnosis and risk stratification. By combining Humanin, GAS5, miR-21, and miR-103, clinicians could ac…
These findings are highly significant as they identify MOTS-c as a critical regulator of pancreatic islet cell senescence, a process implicated in both type 1 and type 2 diabetes. The ability of MOTS-c to reduce senes…
This research highlights the critical role of muscle-fat crosstalk in maintaining metabolic health during aging and provides compelling evidence that its decline can be pharmacologically targeted. The findings suggest…
This research highlights MOTS-c as a promising therapeutic candidate for osteoarthritis, offering a novel approach by simultaneously targeting mitochondrial health, reducing inflammatory cell death, and activating pro…
This comprehensive review highlights MOTS-c as a highly promising therapeutic candidate for Type 2 Diabetes Mellitus (T2DM), offering a multi-pronged approach to combat both metabolic dysfunction and severe cardiac co…
This research highlights MOTS-c as a highly promising therapeutic candidate for intrauterine growth restriction (IUGR), a condition currently plagued by limited effective treatment options. By demonstrating its abilit…
This research highlights the potential of Humanin, Mots-c, and telomere length as novel, non-invasive biomarkers for Alzheimer's disease. Identifying such biomarkers could pave the way for earlier and more accurate di…
This groundbreaking research suggests that circulating MOTS-c could serve as a powerful new diagnostic and prognostic biomarker for Acute Coronary Syndrome and Major Cardiac Events. The ability to identify patients at…
This review establishes a crucial link between mitochondrial-derived microproteins and the pathogenesis of both cancer and neurodegenerative diseases, offering a novel perspective on disease etiology. By identifying c…
This research positions MOTS-c as a highly promising complementary biomarker for assessing treatment response in Multiple Myeloma, offering a novel avenue for patient monitoring. Its dynamic changes could enable earli…
This research highlights MOTS-c as a potent activator of muscle mitochondrial function, offering a novel therapeutic strategy for conditions characterized by mitochondrial dysfunction and muscle decline. By improving …
This review significantly advances our understanding of mitochondria-derived peptides (MDPs) as critical regulators of hepatic metabolism and potential therapeutic agents. The identification of MDPs like MOTS-c and Hu…
These findings suggest that elevated MOTS-c could serve as a novel biomarker for obesity-associated metabolic dysregulation, potentially identifying individuals at higher risk for complications. The persistence of hig…
This review highlights a significant untapped area of research with profound implications for understanding and treating lung diseases. Given the established roles of MDPs in other complex diseases, their investigatio…
This study provides compelling evidence that exogenous MOTS-c can effectively mitigate myocardial ischemia-reperfusion injury by preserving cardiac function, reducing infarct size, and combating oxidative stress. Give…
This research provides compelling evidence that MOTS-c could serve as a novel and effective therapeutic agent for preventing or treating cardiac dysfunction associated with high-altitude exposure. By actively promotin…
This research highlights MOTS-c as a potential biomarker and therapeutic target for Polycystic Ovary Syndrome (PCOS). The strong association between reduced MOTS-c and mitochondrial dysfunction suggests that restoring…
This research highlights MOTS-c as a promising novel therapeutic candidate for Autism Spectrum Disorder, potentially addressing both behavioral symptoms and underlying neurobiological deficits. The ability of MOTS-c t…
This research provides compelling evidence that MOTS-c and humanin could represent novel therapeutic agents for preventing or treating muscle atrophy, particularly in contexts involving corticosteroid use or other cat…
This research highlights MOTS-c as a promising therapeutic candidate for preventing or treating acute liver injury caused by acetaminophen overdose. Its ability to modulate the MAPK signaling pathway and reduce both n…
This research is highly significant as it identifies MOTS-c as a promising therapeutic candidate for preventing or treating bronchopulmonary dysplasia, a major cause of morbidity in premature infants. By activating th…
SS-31 represents a highly promising therapeutic strategy for a wide range of conditions characterized by mitochondrial dysfunction, offering a direct and targeted approach to cellular protection. Its unique ability to…
This detailed chemical profile is crucial for the unambiguous identification and characterization of MOTS-c in research and development. Accurate chemical identification is the bedrock for all subsequent experimental …
Friedreich Ataxia (FRDA) currently lacks effective treatments for vision loss, a symptom that significantly impacts patients' independence and quality of life. Positive results from this pilot study could validate Ela…
This comprehensive screening program holds immense potential to revolutionize early intervention strategies for newborn hearing loss. By identifying genetic causes early, clinicians can offer more personalized prognos…
This research highlights the significant therapeutic potential of N-Acetylcysteine and especially Elamipretide (SS-31) as interventions for ozone-induced respiratory injury. Given that Elamipretide specifically target…
This research highlights a novel therapeutic strategy for ischemic stroke by targeting mitochondrial cardiolipin homeostasis. The findings suggest that modulating cardiolipin can effectively interrupt the damaging cas…
This research powerfully highlights the graviola oil extract's potential as a natural, multi-faceted supplement for significantly enhancing livestock productivity and overall health. By effectively improving fattening…
This research highlights a novel role for MOTS-c in modulating adrenal gland metabolism, specifically by enhancing mitochondrial function and energy production without directly impacting steroid hormone synthesis. Thi…