1187 studies on GLP-1 agonist class curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This ongoing trial is crucial because it addresses a significant unmet medical need, potentially offering a new therapeutic option for adolescent obesity. If successful, the findings could establish tirzepatide as a s…
This study is crucial because it provides real-world evidence supporting Tirzepatide as a highly effective treatment intensification strategy for Type 2 Diabetes patients who are not adequately controlled on GLP-1 RAs…
The study, currently underway, aims to demonstrate the significant efficacy of Tirzepatide in reducing liver fat deposition in patients with Type 2 Diabetes and NAFLD with advanced fibrosis. Based on Tirzepatide's wel…
This research is critically important as it will provide evidence-based guidance for managing incretin-based therapies in patients undergoing upper endoscopy, potentially enhancing patient safety and procedural effici…
This SemaGBA system dynamics model provides a crucial mechanistic understanding of how semaglutide orchestrates its effects on the gut-brain axis to promote weight loss. By simulating complex biological interactions, …
This study provides crucial real-world evidence supporting the safe and effective use of semaglutide in a highly vulnerable patient group where therapeutic options are often limited and complex. The observed improveme…
This research provides compelling evidence for semaglutide's neuroprotective potential beyond its well-known glucose-lowering effects, highlighting a novel mechanism involving the gut-brain axis and sphingolipid metab…
This case report highlights a rare but serious adverse event associated with tirzepatide use, particularly in individuals without pre-existing diabetes or obesity. Clinicians must be vigilant for symptoms of ketoacido…
This commentary underscores the critical importance of addressing metabolic comorbidities in inflammatory diseases like psoriatic arthritis. The hypothetical findings suggest that combining an IL-17A inhibitor with a …
This review highlights that obesity pharmacotherapy should be considered a disease-modifying component of Type 2 Diabetes (T2D) care, moving beyond mere weight reduction. The ability of these drugs to improve a broad …
These findings provide critical clinical guidance, underscoring that semaglutide's profound cardiovascular benefits are robust and complementary to, rather than dependent on, traditional antiplatelet therapy with aspi…
This research highlights the distinct advantages of metabolic bariatric surgery for improving liver health outcomes in patients with co-existing MASLD and T2D, potentially offering a more comprehensive solution for th…
This groundbreaking research underscores the potential of Semaglutide as a multifaceted therapeutic agent, extending its benefits beyond glycemic control and weight management to include significant liver protection. …
These meticulously developed guidelines are profoundly important for enhancing patient safety and optimizing long-term oral health outcomes for the rapidly expanding population of individuals prescribed semaglutide fo…
This research provides compelling evidence that GLP-1 receptor agonists could represent a novel and effective strategy for smoking cessation. The observed reductions in nicotine seeking and withdrawal symptoms, couple…
This network meta-analysis provides crucial evidence that could significantly impact clinical guidelines for managing Type 2 Diabetes patients with high cardiovascular risk. The identification of specific GLP-1 recept…
This research provides robust real-world evidence confirming the effectiveness of GLP-1 therapies in a diverse Middle Eastern population, mirroring results from controlled clinical trials. The observed significant red…
This research provides a more robust and accurate framework for predicting the efficacy and optimizing the dosing of GLP-1 receptor agonists like liraglutide. By precisely accounting for target-mediated drug dispositi…
This comprehensive 'Trial Watch' is crucial for understanding the evolving landscape of MASH treatment and identifying the most promising therapeutic avenues. It provides invaluable insights for clinicians, researcher…
This case series provides crucial preliminary evidence suggesting that GLP-1 RAs can be a safe and effective therapeutic option for weight management in older adults, challenging previous hesitations regarding their u…
This study provides critical safety reassurance regarding the use of these widely prescribed antidiabetic medications, particularly for hematologic malignancy risk. The agent-specific findings highlight the importance…
This case report is highly significant as it identifies a potential rare but serious adverse event associated with tirzepatide use in a patient population not traditionally considered at high risk for ketoacidosis. It…
This review provides strong evidence supporting Tirzepatide's potential as a highly effective therapeutic agent for Metabolically Dysfunctional-Associated Steatohepatitis (MASH), addressing a critical unmet medical ne…
The pervasive and devastating impact of addiction, affecting billions globally and incurring significant health, social, and economic costs, underscores the critical need for innovative treatment strategies. Incretin-…
A deeper understanding of the precise mechanisms underlying beta-cell stress and identity failure is absolutely crucial for the development of novel, disease-modifying therapeutic strategies for type 2 diabetes. This …
This research highlights the critical need for a more personalized approach to semaglutide therapy, moving beyond average treatment effects. Identifying predictors for suboptimal response could enable clinicians to ta…
This case, if substantiated by detailed clinical data, suggests that Semaglutide could represent a novel and effective therapeutic option for patients with Ulcerative Colitis, particularly those who also suffer from o…
This review significantly advances our understanding of GLP-1's extensive therapeutic potential, moving beyond its established role in metabolic health. The detailed exploration of its neuroprotective mechanisms sugge…
This research provides critical reassurance regarding the safety and efficacy of GLP-1 receptor agonists for obesity management. The preservation of muscle mass and function during weight loss is a significant clinica…
This study powerfully underscores the chronic nature of obesity and the significant challenge of weight regain following tirzepatide discontinuation, emphasizing that sustained pharmacological intervention may be nece…
This research provides crucial insights into the pleiotropic effects of Retatrutide, extending its known benefits beyond weight loss and glycemic control to direct adipose tissue repair. The ability of Retatrutide to …
This case report is highly significant given the rapidly expanding use of semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, including its off-label use for weight loss. This finding suggests a potential…
This pooled analysis strongly suggests that Tirzepatide is a highly effective add-on therapy for patients with Type 2 Diabetes who are not achieving optimal glycemic control with basal insulin alone. The dual action a…
These findings are highly significant, as they demonstrate that Tirzepatide, a dual GLP-1/GIP receptor agonist, offers substantial benefits beyond glycemic control and weight loss, directly addressing critical cardiov…
This case report highlights a potential novel therapeutic avenue for ulcerative colitis, suggesting that GLP-1 RAs like semaglutide might offer benefits beyond metabolic control. The observed symptomatic remission and…
This study provides compelling real-world evidence that combining GLP-1 therapy with digital coaching is a highly effective and scalable strategy for obesity management, particularly in diverse populations. The high r…
This pilot study provides compelling evidence that a simple, scalable text messaging program can significantly improve the transition process from basal insulin to GLP-1 RAs, particularly within safety-net populations…
This case report highlights a novel and important consideration for healthcare providers prescribing semaglutide to patients with lower limb amputations. The rapid and significant weight loss induced by GLP-1 agonists…