272 studies on Ghrelin mimetic class curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This study highlights a critical distinction: while GHRP-2 effectively stimulates GH release, this alone may not be sufficient to induce linear growth in children with established GHD. The findings suggest that the un…
This research is highly significant because it directly addresses a major limitation of GHRP-2: its inherently short half-life, which necessitates frequent injections. By successfully synthesizing a mono-PEGylated GHR…
This case report suggests GHRP-2 could be a novel therapeutic strategy for severe anorexia nervosa, particularly for patients struggling with extreme emaciation and metabolic instability. The ability to restore body w…
This study provides compelling evidence that the combination of GHRP-2 and Cysteamine can synergistically enhance growth performance and muscle development in yaks with growth retardation. This could have significant …
This research suggests that the GHRP-2 test could offer a valuable, less invasive, and potentially safer alternative to current diagnostic methods for secondary adrenal failure, such as the insulin tolerance test, whi…
The findings from this research are highly significant as this new panel of genetic and protein biomarkers offers a substantially more robust and prolonged detection window for identifying growth hormone abuse. This e…
This research highlights GHRP-2 as a potential novel therapeutic agent for mitigating ovarian inflammation, which could have significant implications for treating conditions like PCOS or improving fertility outcomes. …
This research suggests that GHRP-2 could serve as a novel and highly specific diagnostic test for thyrotropin-producing pituitary adenomas. The ability to accurately differentiate TSHomas from other conditions is cruc…
The identification of this novel GHRP-2 analogue highlights a concerning trend in illicit drug manufacturing: the deliberate modification of known prohibited substances to create 'designer' peptides that can evade det…
The study revealed that the GHRP2 test consistently induced a robust increase in both ACTH and cortisol levels, mirroring the physiological stress response. Peak cortisol concentrations following GHRP2 administration …
This case is significant as it underscores the critical importance of considering rare endocrine disorders like idiopathic isolated ACTH deficiency in patients presenting with atypical symptoms, even in the absence of…
The widespread detection of impure, underdosed, and potentially contaminated black market Follistatin-344 poses a severe public health threat and undermines fair play in sports. This research provides essential analyt…
This research highlights the potential of the GHRP-2 test as a valuable prognostic tool for patients undergoing surgery for non-functioning pituitary adenomas. By identifying patients more likely to recover GH functio…
This research highlights RECK as a novel and potentially significant regulator within the GH/IGF-1 axis, offering a deeper understanding of growth and metabolic control. Identifying RECK's role could open new avenues …
This fully automated DBS-LC-HRMS method represents a significant advancement in anti-doping analysis, offering a less invasive, more efficient, and highly sensitive approach for detecting illicit substances. The abili…
This study's findings represent a significant advancement in anti-doping science, offering a more effective tool for detecting GHRP-2 abuse. The extended detection window provided by DBS sampling makes it considerably…
This case underscores the critical importance of comprehensive endocrine screening in patients presenting with CFS-like symptoms and fibromyalgia. Identifying and treating underlying hormone deficiencies, such as ACTH…
This review underscores the critical role of endocrine imbalances in the pathophysiology of cachexia and highlights the therapeutic potential of steroid pharmacotherapy. By systematically evaluating the evidence, it p…
The findings suggest that the GHRP-2 test offers a more accurate and reliable method for diagnosing hypothalamic-pituitary disorders, which are often difficult to pinpoint. This could lead to improved early diagnosis …
This research highlights the potential of the GHRP-2 test as a sensitive and specific diagnostic tool for assessing anterior pituitary GH reserve in the elderly, where traditional tests may be less reliable. Accurate …
This study provides compelling evidence for the potent growth hormone-releasing activity of GHRP-2 in healthy adolescents, confirming its strong pharmacological effect in this age group. The robust and consistent GH r…
This research highlights GHRP-2 as a promising therapeutic agent for improving rotator cuff tear repair by directly targeting the inflammatory response and enhancing tissue regeneration. By reducing detrimental M1 mac…
This study provides a critical benchmark for ACTH cell dosage in regenerative medicine, offering a clear path forward for developing more effective therapies for post-operative hypopituitarism and associated adrenal i…
This research provides crucial analytical standards and degradation profiles that can significantly enhance anti-doping detection capabilities. By understanding how these peptides break down, forensic laboratories can…
This research provides crucial, mechanistic insight into the direct neural targets of nonpeptide growth hormone secretagogues like MK-0677. Understanding how these compounds specifically activate neurons in the arcuat…
Why It Matters This study provides the first definitive evidence for specific, high-affinity GH secretagogue receptors in key human tissues, fundamentally advancing our understanding of how these compounds exert their…
This early review was pivotal in identifying a novel therapeutic strategy for addressing growth and endocrine complications in thalassemia. By proposing the use of GH secretagogues, the authors opened a new direction …
This research is significant because it definitively establishes the pituitary-dependent mechanism of MK-0677. Understanding this mechanism is crucial for developing and safely utilizing growth hormone secretagogues, …
This research highlights that MK-677 can significantly modulate lipoprotein profiles in obese individuals, demonstrating its potential metabolic activity beyond just growth hormone stimulation. The observed reductions…
This research provides compelling evidence that human pituitary adenomas express functional growth hormone secretagogue receptors, which can directly influence hormone secretion. This discovery is crucial because it s…
This study provides crucial insights into the neurobiological mechanisms underlying chronic GHS action, particularly their influence on hypothalamic circuits regulating energy balance. The observed upregulation of ore…
This comprehensive review underscores the broad therapeutic potential of GHS across multiple organ systems and conditions. The observed benefits, from cardioprotection and growth promotion to metabolic improvements an…
This landmark review fundamentally reshaped the understanding of GH modulation, establishing GHSs as a powerful and physiologically relevant therapeutic strategy. By stimulating endogenous GH, GHSs offered a pathway t…
This research significantly advances our understanding of how growth hormone secretagogues (GHS) exert their effects on the brain, revealing a novel, non-noradrenergic signaling pathway. This discovery is crucial beca…
This research provides crucial analytical and preparative separation techniques essential for the development of new growth hormone secretagogue drugs. By enabling the purification of individual diastereomers, it allo…
This review critically highlights the therapeutic potential of GHRPs beyond their established GH-releasing properties, suggesting they could be novel pharmacological agents for treating various cardiovascular diseases…
This discovery fundamentally expands our understanding of GHSR regulation beyond ghrelin, suggesting a broader physiological role for this receptor. It implies that adenosine, a ubiquitous signaling molecule involved …
The study successfully identified adenosine as a partial agonist of the GHS-R, meaning it can activate the receptor but not to its full potential. Activation of GHS-R by adenosine was significantly inhibited by select…
This groundbreaking research significantly expands our understanding of GHS physiology, indicating that these compounds, and potentially the endogenous ligand ghrelin, have direct actions on multiple peripheral organs…
This study provides critical direct evidence for the presence of ghrelin receptors in key human brain regions, specifically the hypothalamus and pituitary gland, which are central to regulating appetite, energy homeos…
This foundational review consolidated critical knowledge about the GHS-R system, providing a robust framework that significantly influenced subsequent research and drug discovery efforts. It highlighted the immense po…
This research is significant because it highlights the complex interplay between hexarelin and different cardiac cell types, specifically emphasizing the often-overlooked role of endothelial cells in mediating drug ef…
This study highlights SM-130686 as a potent, selective, and orally active growth hormone secretagogue. Its ability to significantly boost GH levels and improve lean body mass in an animal model suggests considerable t…