272 studies on Ghrelin mimetic class curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This research highlights a novel and potentially significant role for synthetic peptidyl GH secretagogues beyond their traditional endocrine functions, suggesting they could be repurposed as direct anticancer agents. …
This comprehensive review highlights ghrelin's multifaceted nature, demonstrating it is far more than just a GH secretagogue. Understanding ghrelin's broad actions opens new avenues for therapeutic development and dru…
This research is crucial as it highlights the potential of ghrelin and synthetic growth hormone secretagogues as novel therapeutic agents for treating acute ischemic heart disease, such as myocardial infarction (heart…
The development of GHSs represents a paradigm shift in treating conditions associated with GH deficiency or catabolic states. These compounds offer a non-invasive, orally active alternative to recombinant GH, potentia…
This research significantly expands our understanding of how growth hormone secretagogues interact with the ghrelin receptor, moving beyond simple agonism to reveal a sophisticated allosteric modulation. This dual mec…
This systematic methodology represents a significant advancement in pharmaceutical quality control and drug development, offering a standardized framework for impurity tracking. By enabling the early and thorough iden…
These robust findings underscore the significant therapeutic potential of ghrelin receptor agonists as a multifaceted strategy for intervening in and potentially reversing various aspects of age-related decline. The o…
This synthesis highlights the GH/IGF-I axis as a critical endocrine regulator in Alzheimer's disease, offering a novel perspective on its pathogenesis. Understanding this intricate relationship could pave the way for …
This research provides a fundamental and detailed understanding of how the ghrelin receptor is activated by a wide array of molecules, from its natural peptide hormone to synthetic small molecules. Identifying this sh…
This research provides a fundamental understanding of the precise mechanism by which GHS and GHRPs activate the Ghrelin receptor, specifically concerning Galpha(o1) signaling. The identification of these compounds as …
These findings suggest that MK-0677 could be a valuable therapeutic agent to enhance recovery and improve long-term outcomes for patients following hip fracture. By promoting muscle strength and functional mobility, i…
These findings highlight ghrelin's crucial role in modulating fear memory consolidation, suggesting that dysregulated ghrelin signaling could significantly contribute to the pathophysiology of conditions like Post-Tra…
This research highlights the critical and previously underappreciated role of GHS-R1a in the pathogenesis of neurogenic hypertension and its associated renal dysfunction. The strong association between GHS-R1a underex…
This research significantly advances our understanding of how transcriptional regulation impacts fundamental neuronal function and excitability. The findings highlight Satb1 and Satb2 as critical regulators of glutama…
This study presents a paradigm shift in how complex nonlinear signals can be analyzed, offering a powerful tool for fields beyond theoretical physics. For the biotech and peptide community, this AI-driven approach cou…
This research provides a critical advancement for anti-doping strategies in equine sports, particularly for Thoroughbred racing. By identifying long-lived metabolites and establishing their detection windows, regulato…
This groundbreaking research provides a robust and significantly extended detection method for MK-0677, poised to revolutionize anti-doping strategies in equine sports. The ability to detect this potent growth hormone…
The discovery of these novel, orally active growth hormone secretagogues represents a significant advancement in the field of endocrinology and drug development. Oral administration offers a more convenient and patien…
This study marks a significant advancement by identifying Ipamorelin as the first truly selective growth hormone secretagogue, offering a cleaner pharmacological profile. The absence of significant prolactin or cortis…
This research highlights Ipamorelin's potential as a potent and selective growth hormone secretagogue capable of directly stimulating bone growth. Its efficacy, comparable to recombinant human GH in this model, sugges…
The discovery of NN703 as a potent and orally bioavailable GH secretagogue represents a significant advancement in the field of endocrinology. An oral GH secretagogue could revolutionize the treatment paradigm for con…
This research provides critical insights into the pharmacology of ipamorelin, establishing a robust quantitative link between its systemic exposure and its growth hormone-releasing effects in humans. Understanding thi…
This finding is highly significant because it suggests that this novel GHS could potentially be effective even in individuals undergoing glucocorticoid therapy, where GH secretion is often suppressed. This could open …
This foundational research is profoundly significant as it underscores the promising potential of GH secretagogues as a novel therapeutic strategy for managing and preventing conditions characterized by bone loss, suc…
This study reveals a critical GH-independent mechanism by which GHSs can increase body fat, potentially driven by increased feeding and altered metabolic signaling. This finding is highly significant for understanding…
This research provides a crucial mechanistic insight into how GHRPs stimulate growth hormone release, suggesting a significant interaction with the body's endogenous ghrelin system. Understanding this pathway could le…
This research significantly deepens our understanding of ghrelin's structure-activity relationship, particularly concerning its minimal active core and the critical role of specific amino acid positions. The identific…
This research highlights a successful strategy for designing highly potent growth hormone secretagogues by combining structural features from different active compounds. The discovery that re-introducing specific mole…
This research highlights Ipamorelin's potential to mitigate severe side effects of glucocorticoid therapy, which are widely used but often limited by their catabolic impact on bone and muscle. By demonstrating that Ip…
This study provides crucial insights into the long-term effects of Ipamorelin on the pituitary, demonstrating that chronic administration can lead to a sustained enhancement of somatotroph function and GH release capa…
This research successfully identified novel growth hormone secretagogues with significantly improved potency and, crucially, excellent oral bioavailability. The development of orally active GHS is a major step forward…
This study highlights a critical paradox in diabetes: GH hypersecretion coexisting with peripheral GH receptor resistance. This finding suggests that the body attempts to compensate for impaired GH signaling by increa…
This research is significant because it identifies a novel role for Ipamorelin beyond its known growth hormone-releasing effects, demonstrating its ability to directly stimulate insulin secretion. The finding that Ipa…
This research provides the first comprehensive molecular characterization of ghrelin in seabream, a commercially important aquaculture species. Understanding the genetic structure and regulatory elements of seabream g…
This study provides compelling evidence that both growth hormone and growth hormone secretagogues can effectively mitigate the severe catabolic effects of steroid treatment, specifically by improving nitrogen balance …
This study provides compelling evidence that ipamorelin, a novel ghrelin mimetic, can effectively mitigate the symptoms and accelerate recovery from postoperative ileus in a preclinical model. The observed improvement…
This study provides a highly sensitive and robust analytical tool that significantly enhances the capabilities of anti-doping laboratories to detect GHRP abuse. By simultaneously identifying both parent GHRPs and thei…
This research highlights ipamorelin's potential as a novel therapeutic agent for managing postoperative ileus by directly addressing gastric dysmotility and associated inflammation. Its ability to accelerate gastric e…
This advanced analytical method significantly enhances anti-doping efforts by providing a highly sensitive, robust, and expandable tool for detecting a broad panel of small prohibited peptides. The ability to detect t…
Understanding these specific metabolic pathways is crucial for anti-doping efforts, enabling the development of more sensitive and specific detection methods for the misuse of performance-enhancing GHRPs. This researc…
This advanced analytical method provides a crucial tool for anti-doping agencies to combat the illicit use of GHRPs in both equine and human sports. By enabling reliable and high-throughput detection, it helps ensure …
This study provides compelling early evidence that ipamorelin, by mimicking the action of ghrelin (a hormone that stimulates appetite and GI motility), can effectively accelerate gastrointestinal recovery after bowel …
This research significantly enhances anti-doping capabilities by providing specific, long-lasting biomarkers for GHRPs administered nasally. The identification of these metabolites means that athletes misusing these s…
This detailed structure-activity relationship analysis provides invaluable insights for the rational design of next-generation peptidic growth hormone secretagogues. Understanding how specific amino acid changes impac…
This pilot study provides compelling evidence that a specialized doping control container can substantially enhance the stability of urine samples, ensuring the accurate detection of prohibited substances over extende…