Novel Chemical Reaction Efficiently Builds Complex Drug-Like Spirocyclic Piperidines

Electrophile-induced dearomatizing spirocyclization of N-arylisonicotinamides: a route to spirocyclic piperidines. Authors: Arnott G, Brice H, Clayden J, Blaney E Journal: Organic letters (2008) DOI: 10.1021/ol801092s Treatment of N-aryli…