94 studies on Ghrelin receptor mechanism curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This research provides crucial insights into how major public health crises can influence substance use behaviors, particularly concerning PIEDs. The observed shift towards online procurement and mental health-driven …
The discovery and characterization of GHS-R3a significantly expands our understanding of the ghrelin system's complexity and evolution in vertebrates. This novel receptor provides new insights into the intricate mecha…
This research highlights a promising therapeutic avenue for obesity and related metabolic disorders by leveraging the body's own growth hormone system. Activating the GHSR could offer a strategy to improve body compos…
This research highlights the significant neuroprotective potential of ghrelin receptor agonists, such as Hexarelin and JMV2894, in mitigating the cellular damage associated with the SOD1-G93A mutation, a key driver of…
This review is crucial for consolidating the vast knowledge surrounding ghrelin and identifying critical areas for future research and development. Understanding ghrelin's diverse physiological roles and the hurdles t…
Understanding the interplay between GLP-1 receptor agonists like semaglutide and the ghrelin system is crucial for optimizing obesity treatments. If blocking the ghrelin receptor with LEAP2 proves beneficial, it could…
This research uncovers a novel and crucial gut-brain-liver axis where gut-derived ghrelin plays a pivotal role in the systemic regulation of glucose metabolism. Understanding this intricate pathway provides significan…
This research uncovers a previously unknown direct link between ghrelin and oxytocin, suggesting that ghrelin's influence extends beyond appetite regulation to potentially impact broader metabolic and behavioral pathw…
This study provides compelling evidence that both Ghrelin and LHA electrical stimulation can effectively normalize the pathological hyperactivity of gastric distention neurons in a cisplatin-induced gastric dysfunctio…
This research highlights a novel strategy for overcoming acquired drug resistance in lung cancer, a major clinical challenge. By targeting the ghrelin receptor, this study demonstrates a potential pathway to re-sensit…
This study provides compelling evidence that Ghrelin/GHSR signaling plays a crucial role in protecting hippocampal neurogenesis from chronic stress-induced damage, leading to improved mood-related behaviors. This sugg…
These findings are highly significant as they demonstrate that Ghrelin acts as a potent neuroprotective agent against HIE-induced brain injury by modulating oxidative stress and neuronal apoptosis. The elucidation of …
This study highlights that GHSR signaling can directly influence high-fat food intake in a binge eating context, independent of circulating ghrelin and LEAP2 levels. This suggests a novel, direct role for GHSR in the …
This research highlights a novel pathway for treating alcoholic hepatic steatosis, a critical precursor to more severe alcoholic liver disease. The findings suggest that ghrelin receptor antagonism could be a promisin…
This research uncovers a novel and critical brain-gut axis involving ghrelin that directly regulates glycolipid metabolism, providing a deeper understanding of how the brain controls energy homeostasis. The identifica…
This research highlights a critical mechanism by which estradiol replacement therapy can combat post-menopausal obesity by directly modulating the ghrelin pathway. Understanding this interaction provides a novel thera…
This research highlights a novel neuro-gastrointestinal pathway where central ghrelin signaling can protect the gut barrier from inflammatory insults. The findings suggest that targeting ghrelin receptors in the brain…
This research highlights a novel role for the ghrelin receptor system in modulating opioid tolerance, suggesting that targeting these receptors could offer a new therapeutic strategy. Attenuating morphine tolerance co…
This research highlights the potential of ghrelin antagonists as therapeutic targets for managing conditions characterized by excessive hunger or metabolic dysregulation. By demonstrating that blocking ghrelin can mod…
Understanding the precise molecular interactions between these novel peptides and the ghrelin receptor is critical for rational drug design. This in silico strategy provides a powerful framework for optimizing existin…
This study's elucidation of the atomic-level molecular recognition of ghrelin by its receptor provides invaluable structural templates that are poised to revolutionize rational drug design. By understanding exactly ho…
This research highlights the ghrelin-GOAT system as a critical modulator of food reward and motivation, offering a promising new therapeutic target for eating disorders. By specifically inhibiting GOAT, it's possible …
This research highlights a novel therapeutic strategy: targeting the ghrelin signaling pathway to enhance the success of islet transplantation. By improving graft survival and function, this approach could significant…
This research highlights the therapeutic potential of ghrelin receptor antagonism in mitigating the adverse physiological and behavioral responses associated with immune challenges. By effectively reducing sickness be…
This study reveals a critical and previously underappreciated role for the ghrelin receptor type 1a (GHSR1a) in modulating seizure susceptibility and severity within the brain. The finding that GHSR1a antagonism drama…
This research provides a mechanistic understanding of how enteral nutrition combats hypercatabolism, highlighting the critical role of the ghrelin/GHS-R1α-POMC pathway. The findings suggest that optimizing enteral fee…
This research highlights Meranzin Hydrate's potential as a novel therapeutic agent for depression and associated motor deficits, acting through the ghrelin system and neuroplasticity pathways. The findings suggest a p…
This research uncovers a novel mechanism by which oral L-ornithine stimulates growth hormone (GH) secretion, specifically implicating ghrelin receptor-mediated pathways. Understanding this interaction could open new a…
This study provides compelling evidence that targeting ghrelin receptors in the brain offers a novel therapeutic strategy for NAFLD and associated metabolic dysfunctions. By improving hypothalamic insulin resistance, …
This study provides critical insights into the metabolic regulatory functions of ghrelin, particularly its role in modulating liver fat and glucose metabolism. The findings suggest that ghrelin's normal activity might…
This study highlights Ghrelin's significant potential as a therapeutic agent for preventing or treating intestinal ischemia-reperfusion injury. By modulating the GHSR-1α/Sirt1/FOXO1 pathway, Ghrelin offers a novel and…
This groundbreaking research provides a fundamental and unprecedented understanding of how ghrelin directly influences cellular excitability and signaling by precisely modulating VGCCs. This direct molecular interacti…
The study yielded compelling evidence that ghrelin is indeed indispensable for the characteristic blood pressure reduction during torpor. A striking difference was observed: ghrelin-deficient mice exhibited a signific…
This study provides compelling evidence that intranasal delivery is a viable and effective route for engaging the brain's ghrelin signaling system. This non-invasive approach could circumvent the challenges of systemi…
This research highlights Danshen-Chuanxiong-Honghua (DCH) as a promising multi-target therapeutic agent for traumatic brain injury, offering both anti-inflammatory and neuroprotective benefits. The specific identifica…
This research provides crucial insights into the potentiation of GH secretion when GHRH and GHRPs are co-administered, suggesting a more efficient way to stimulate endogenous GH release. The observed synergy could all…
This research provides crucial insights into the dual action of GHRP-2, confirming its potent ability to both stimulate appetite and enhance upper gastrointestinal motility in a large animal model. The strong orexigen…
This research highlights a significant potential for GHRP-2 as a therapeutic agent to combat the debilitating muscle wasting associated with severe thermal injuries. By attenuating the expression of key muscle breakdo…
This research highlights a novel regulatory mechanism for ACTH secretion, involving the interplay between BMP and GHRP signaling pathways. Understanding these interactions is crucial for comprehending the intricate co…
This research is significant because it identifies an alternative pathway for stimulating growth hormone release in a severe model of GH deficiency. The finding that GHRP-2 can bypass the primary genetic defect in Ghr…
The discovery of ghrelin fundamentally transformed our understanding of growth hormone regulation, appetite control, and energy balance. It revealed a novel endocrine system linking the gut directly to the brain's neu…
This study highlights a critical distinction: while GHRP-2 effectively stimulates GH release, this alone may not be sufficient to induce linear growth in children with established GHD. The findings suggest that the un…
This research suggests that GHRP-2 could serve as a novel and highly specific diagnostic test for thyrotropin-producing pituitary adenomas. The ability to accurately differentiate TSHomas from other conditions is cruc…