31 studies on Blood-brain barrier mechanism curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This study highlights the neuroprotective and regenerative potential of Elamipretide (SS-31) in the context of spinal cord injury. By directly targeting mitochondrial dysfunction and promoting neural remodeling, Elami…
This finding is significant because it confirms that liraglutide can reach the central nervous system (CNS), providing a physiological basis for its observed central effects on appetite regulation, glucose homeostasis…
These findings are crucial as they establish a direct mechanistic link between tau oligomers and blood-brain barrier dysfunction, a critical early event in neurodegenerative diseases like Alzheimer's. The activation o…
This research highlights Kisspeptin-10 as a promising novel therapeutic agent for combating the neurological complications of HIV-1 infection, particularly HIV-associated neurocognitive disorders (HAND). By specifical…
This groundbreaking research identifies Kisspeptin-10 as a highly promising therapeutic agent for mitigating post-stroke brain injury by directly targeting and preserving the blood-brain barrier. By significantly upre…
This research is highly significant because it establishes a robust, efficient, and scalable method for producing a modified Delta Sleep-Inducing Peptide (DSIP) with enhanced pharmacokinetic properties. The successful…
This research represents a significant advancement by demonstrating a scalable and efficient method for producing therapeutic peptides that can effectively overcome the formidable challenge of the blood-brain barrier.…
This research offers a crucial breakthrough in the quest for oral peptide drug delivery, potentially revolutionizing how many chronic conditions are treated. By identifying effective strategies to boost intestinal per…
This research provides crucial insights into the central mechanism of action for Survodutide, demonstrating its direct engagement with brain regions critical for appetite regulation. Understanding that Survodutide act…
This study highlights the significant potential of NRP1-PDC as a dual-action therapeutic strategy for highly aggressive cancers like glioblastoma. By simultaneously targeting tumor cells and their blood supply through…
This study introduces a powerful and innovative computational approach, Direct Preference Optimization, that can revolutionize the design of macrocyclic drugs with significantly improved permeability and oral bioavail…
This research provides a powerful new strategy for designing highly efficient cell-penetrating peptides, potentially revolutionizing drug delivery systems. By precisely engineering secondary structures with non-protei…
This research offers a highly promising novel strategy for improving the treatment of severe and often fatal fungal encephalitis. By leveraging melittin's ability to temporarily modulate the blood-brain barrier (BBB),…
Understanding metformin's brain-mediated actions represents a critical advancement, opening entirely new avenues for optimizing existing T2D treatment strategies and developing innovative therapies. This deeper mechan…
Understanding the acute cognitive impacts of high-altitude hypoxia is crucial for safety and performance in various contexts, including mountaineering, military operations, and occupational tasks in high-altitude envi…
This research is profoundly important as Type 2 Diabetes (T2D) significantly elevates the risk of severe cerebrovascular events like stroke, and understanding semaglutide's direct impact on brain health is critical. I…
This research significantly advances our understanding of spinal cord injury pathology by identifying a critical role for cPLA2-mediated lysosomal membrane permeabilization in driving pyroptosis. The finding that Elam…
The study yielded compelling evidence that ghrelin is indeed indispensable for the characteristic blood pressure reduction during torpor. A striking difference was observed: ghrelin-deficient mice exhibited a signific…
This study provides compelling evidence that intranasal delivery is a viable and effective route for engaging the brain's ghrelin signaling system. This non-invasive approach could circumvent the challenges of systemi…
This research highlights a significant new therapeutic potential for GHRH antagonists, particularly MIA-602, in conditions involving blood-brain barrier dysfunction. Given their ability to protect brain microvascular …
This research significantly advances our understanding of how transcriptional regulation impacts fundamental neuronal function and excitability. The findings highlight Satb1 and Satb2 as critical regulators of glutama…
This research provides crucial insights into the neurobiological mechanisms underlying the known anxiolytic and nootropic effects of Selank and Semax. Understanding how these peptides modulate specific brain networks …
This research highlights MOTS-c as a promising therapeutic candidate for mitigating sepsis-associated brain injury by directly targeting the blood-brain barrier. The ability of MOTS-c to preserve BBB integrity and red…
This research highlights bremelanotide's potential as a novel therapeutic candidate for glioblastoma, a highly aggressive and treatment-resistant brain cancer. Given its known safety profile from other clinical applic…
This innovative biodegradable suction patch represents a significant advancement in non-invasive drug delivery, particularly for peptide-based therapeutics. By offering sustained release and high bioavailability throu…
If this study reveals positive findings, it could significantly expand our understanding of non-pharmacological interventions for cognitive enhancement. Demonstrating that balance exercises, whether traditional or gam…