12 studies on MC4R mechanism curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This study definitively establishes glutamate as the primary neurotransmitter mediating MC4R function on Sim1 neurons in the complex process of body weight regulation. This fundamental discovery significantly advances…
This research identifies a previously unrecognized brain circuit involving the Mes5 and NTS POMC neurons that plays a crucial role in regulating appetite and body weight. Understanding this pathway could open new aven…
This research highlights the significant therapeutic potential of melanocortin peptides in addressing unmet medical needs. The development of MTI could offer a novel, preventative approach to skin cancer through induc…
This retraction highlights the critical importance of research integrity and transparency in scientific publishing. Unverified or fraudulent data can mislead future research and potentially harm patients if treatments…
The approval of bremelanotide represents a pivotal advancement in addressing a significant unmet medical need for women experiencing HSDD. Its unique profile as a self-administered, on-demand subcutaneous therapy offe…
This review consolidates extensive research, providing a clear roadmap for future drug development targeting the melanocortin system. The identification of potent and selective ligands for MC3R and MC4R offers novel a…
This review profoundly underscores the immense and expanding potential of the central melanocortin system as a drug target for a wide array of metabolic and behavioral disorders. The established safety profile and cli…
The provided clinical trial registration record, which concluded in May 2007, confirms that the study successfully completed its 8-week duration as planned. However, specific efficacy and safety results, including det…