94 studies on Ghrelin receptor mechanism curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
The findings suggest that the GHRP-2 test offers a more accurate and reliable method for diagnosing hypothalamic-pituitary disorders, which are often difficult to pinpoint. This could lead to improved early diagnosis …
This research highlights the potential of the GHRP-2 test as a sensitive and specific diagnostic tool for assessing anterior pituitary GH reserve in the elderly, where traditional tests may be less reliable. Accurate …
This study provides compelling evidence for the potent growth hormone-releasing activity of GHRP-2 in healthy adolescents, confirming its strong pharmacological effect in this age group. The robust and consistent GH r…
Why It Matters This study provides the first definitive evidence for specific, high-affinity GH secretagogue receptors in key human tissues, fundamentally advancing our understanding of how these compounds exert their…
This early review was pivotal in identifying a novel therapeutic strategy for addressing growth and endocrine complications in thalassemia. By proposing the use of GH secretagogues, the authors opened a new direction …
This research provides compelling evidence that human pituitary adenomas express functional growth hormone secretagogue receptors, which can directly influence hormone secretion. This discovery is crucial because it s…
This study provides crucial insights into the neurobiological mechanisms underlying chronic GHS action, particularly their influence on hypothalamic circuits regulating energy balance. The observed upregulation of ore…
This research highlights the complex neuroendocrine regulation of growth hormone secretagogue action within the hypothalamus. Understanding these interactions could be crucial for developing more targeted therapies fo…
This comprehensive review was instrumental in solidifying the understanding of the GHSR-1a pathway as a major regulator of GH secretion, independent of GHRH. The identification of orally active, non-peptidic GHS like …
This review significantly expanded the understanding of GHS pharmacology, moving beyond their traditional role in GH deficiency. The identification of diverse non-endocrine actions, such as effects on appetite, metabo…
This landmark review fundamentally reshaped the understanding of GH modulation, establishing GHSs as a powerful and physiologically relevant therapeutic strategy. By stimulating endogenous GH, GHSs offered a pathway t…
This discovery fundamentally expands our understanding of GHSR regulation beyond ghrelin, suggesting a broader physiological role for this receptor. It implies that adenosine, a ubiquitous signaling molecule involved …
The findings suggest that GHS represent a promising therapeutic strategy for combating age-related decline in GH and IGF-1, potentially improving body composition and overall vitality in older adults. By stimulating e…
This groundbreaking research significantly expands our understanding of GHS physiology, indicating that these compounds, and potentially the endogenous ligand ghrelin, have direct actions on multiple peripheral organs…
This study provides critical direct evidence for the presence of ghrelin receptors in key human brain regions, specifically the hypothalamus and pituitary gland, which are central to regulating appetite, energy homeos…
This study highlights SM-130686 as a potent, selective, and orally active growth hormone secretagogue. Its ability to significantly boost GH levels and improve lean body mass in an animal model suggests considerable t…
This comprehensive review highlights ghrelin's multifaceted nature, demonstrating it is far more than just a GH secretagogue. Understanding ghrelin's broad actions opens new avenues for therapeutic development and dru…
This research significantly expands our understanding of how growth hormone secretagogues interact with the ghrelin receptor, moving beyond simple agonism to reveal a sophisticated allosteric modulation. This dual mec…
This discovery of highly potent GHSs like compound 8 holds significant therapeutic potential for a range of conditions. Such compounds could be invaluable for treating growth hormone deficiency, combating sarcopenia (…
These robust findings underscore the significant therapeutic potential of ghrelin receptor agonists as a multifaceted strategy for intervening in and potentially reversing various aspects of age-related decline. The o…
This research provides a fundamental and detailed understanding of how the ghrelin receptor is activated by a wide array of molecules, from its natural peptide hormone to synthetic small molecules. Identifying this sh…
This research provides a fundamental understanding of the precise mechanism by which GHS and GHRPs activate the Ghrelin receptor, specifically concerning Galpha(o1) signaling. The identification of these compounds as …
These findings highlight ghrelin's crucial role in modulating fear memory consolidation, suggesting that dysregulated ghrelin signaling could significantly contribute to the pathophysiology of conditions like Post-Tra…
This study provides compelling evidence that MK-0677, an oral ghrelin receptor agonist, can effectively increase IGF-1 levels in hemodialysis patients. This is a critical step towards addressing the IGF-1 deficiency o…
This research highlights the critical and previously underappreciated role of GHS-R1a in the pathogenesis of neurogenic hypertension and its associated renal dysfunction. The strong association between GHS-R1a underex…
This research provides a critical advancement for anti-doping strategies in equine sports, particularly for Thoroughbred racing. By identifying long-lived metabolites and establishing their detection windows, regulato…
This groundbreaking research provides a robust and significantly extended detection method for MK-0677, poised to revolutionize anti-doping strategies in equine sports. The ability to detect this potent growth hormone…
This research underscores the chronic nature of obesity and highlights that GLP-1 receptor agonists function as effective long-term management tools rather than curative treatments. The rapid weight regain and metabol…
This research significantly deepens our understanding of ghrelin's structure-activity relationship, particularly concerning its minimal active core and the critical role of specific amino acid positions. The identific…
This research provides the first comprehensive molecular characterization of ghrelin in seabream, a commercially important aquaculture species. Understanding the genetic structure and regulatory elements of seabream g…
This study provides compelling early evidence that ipamorelin, by mimicking the action of ghrelin (a hormone that stimulates appetite and GI motility), can effectively accelerate gastrointestinal recovery after bowel …
This research demonstrates that incorporating a meta-carborane scaffold can effectively improve the metabolic stability of peptide agonists without compromising their potency or selectivity for the ghrelin receptor. T…
This research is significant as it expands our understanding of ghrelin's role beyond metabolism and growth, specifically highlighting its influence on reproductive physiology in non-mammalian vertebrates. For the aqu…
This research highlights the significant potential of GHS-R1a agonists like anamorelin and ipamorelin as novel therapeutic agents for managing chemotherapy-induced cachexia and emesis. The dual benefit of anamorelin i…
These findings suggest that Ipamorelin could be a promising therapeutic agent for conditions characterized by growth hormone deficiency, sarcopenia, or osteoporosis. Its selective action as a growth hormone secretagog…
The study revealed that acute stress robustly suppressed hunger-driven food seeking in the animal model. This suppression was directly correlated with increased activation of neurons within the PVN, suggesting a criti…