39 studies on Mitochondrial biogenesis mechanism curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This pilot study provides compelling evidence that Estrogen-Related Receptors (ERRs) represent a highly promising and previously under-explored therapeutic target for combating sarcopenia and disuse-induced muscle atr…
This research highlights the therapeutic potential of targeting ERR pathways to combat heart failure by directly addressing its underlying metabolic dysfunction. By enhancing the heart's ability to generate energy and…
This study identifies a novel mechanism by which Oroxylin A can combat NAFLD, highlighting its potential as a therapeutic agent. By modulating CPT1A through m6A methylation, Oroxylin A directly addresses the core meta…
This groundbreaking study introduces a highly effective and targeted strategy for delivering thermogenic agents, presenting a novel and potentially safer pathway for obesity treatment. By specifically boosting mitocho…
This review significantly advances our understanding of Diabetic Kidney Disease (DKD) by firmly establishing mitochondrial dynamics as a crucial pathogenic mechanism. Identifying specific pathways within mitochondrial…
These findings suggest that MOTS-c could serve as a novel biomarker for PCOS diagnosis or severity, and its genetic variants might identify individuals at higher risk. Understanding this metabolic link opens avenues f…
This research highlights the potential of synovial fluid mtDNA as a novel, non-invasive biomarker for assessing cartilage damage severity after joint injury. Such a biomarker could significantly improve early diagnosi…
This review highlights the critical role of mitochondrial health in NAFLD pathogenesis and underscores the immense potential of mitochondrial-targeted therapies. By summarizing the efficacy of various compounds and me…
This research is significant because it identifies a specific mechanism by which elamipretide (SS-31) can counteract age-related mitochondrial decline. By improving ADP sensitivity and enhancing ANT function, SS-31 co…
Understanding these intricate molecular mechanisms is profoundly crucial for the rational design and optimization of more effective mitochondria-targeted therapeutics. By elucidating precisely how specific peptide seq…
This discovery represents a pivotal breakthrough in understanding the mechanism of action of SS-31, a drug with significant therapeutic potential across a range of mitochondrial dysfunction-related diseases. Identifyi…
This study provides compelling evidence that MitoPeptide-X can effectively reverse skeletal muscle mitochondrial dysfunction and improve muscle performance in a preclinical model of metabolic disease. This identifies …
This extensive review highlights the critical and multifaceted role of mitochondrial dysfunction in driving the aging process and underscores the significant therapeutic potential of targeting these organelles. The co…
This research provides crucial insights into the molecular mechanisms underlying angiotensin II-induced kidney damage, highlighting Sirt6 as a key regulator of lipid metabolism in podocytes. The findings suggest that …
These findings are highly significant as they demonstrate that Ghrelin acts as a potent neuroprotective agent against HIE-induced brain injury by modulating oxidative stress and neuronal apoptosis. The elucidation of …
This research highlights that the central melanocortin system plays a distinct and enhanced role in regulating physical activity and skeletal muscle metabolism in individuals predisposed to leanness and high activity.…
This research highlights PGC-1α activation as a promising therapeutic strategy for mitigating brain damage following ischemic stroke. By enhancing mitochondrial function and reducing oxidative stress, PGC-1α activator…
This research uncovers a novel antiviral mechanism for MOTS-c, demonstrating its potent ability to combat HBV infection by modulating mitochondrial dynamics. This unique approach could offer a significant advantage ov…
This research highlights the significant therapeutic potential of MOTS-c as a novel intervention for myocardial infarction, offering a promising strategy beyond conventional treatments. By targeting mitochondrial func…
This study provides compelling evidence that MOTS-c peptide could be a novel and effective therapeutic agent for diabetic cardiomyopathy. Its ability to improve cardiac function, reduce fibrosis, and mitigate oxidativ…
This research highlights MOTS-c as a promising therapeutic agent for combating muscle wasting and associated fat infiltration caused by immobilization. The ability of MOTS-c to simultaneously preserve muscle mass and …
This research provides compelling evidence that mitochondria-derived peptides represent a novel and promising therapeutic strategy for treating painful diabetic neuropathy. By directly targeting mitochondrial dysfunct…
The study unequivocally revealed a significant and consistent association between markers of mitochondrial dysfunction and poorer cognitive performance across several critical domains in adults with OSA. Specifically,…
This study identifies MOTS-c as a promising novel therapeutic agent for cancer-induced bone pain, addressing a significant unmet medical need in oncology. Its unique mechanism through AMPK-mediated mitochondrial bioge…
This study provides a robust mechanistic framework for understanding how MOTS-c protects the brain after traumatic injury, highlighting its role in enhancing mitochondrial function and reducing inflammation and oxidat…
This research provides a novel mechanistic understanding of how endurance training improves skeletal muscle mitochondrial function, highlighting MOTS-c as a key player. The findings suggest that circulating MOTS-c lev…
This research significantly advances our understanding of MOTS-c as a potent regulator of muscle development and metabolism, highlighting its potential to improve muscle health across different fiber types. The findin…
This research is crucial for understanding the pleiotropic effects (multiple beneficial actions beyond the primary one) of GLP-1RAs and SGLT-2is in diabetes. By elucidating their impact on neurohumoral and mitochondri…
Circulating PGC-1α and MOTS-c could serve as novel, non-invasive biomarkers for assessing mitochondrial health, predicting post-operative complications, and stratifying risk in AVR patients. This could enable earlier …
These findings highlight MOTS-c as a highly promising therapeutic candidate for treating diabetic cardiomyopathy by directly addressing the underlying mitochondrial dysfunction. The ability of MOTS-c to restore fundam…
This research highlights the critical role of muscle-fat crosstalk in maintaining metabolic health during aging and provides compelling evidence that its decline can be pharmacologically targeted. The findings suggest…
This comprehensive review highlights MOTS-c as a highly promising therapeutic candidate for Type 2 Diabetes Mellitus (T2DM), offering a multi-pronged approach to combat both metabolic dysfunction and severe cardiac co…
This research highlights MOTS-c as a potent activator of muscle mitochondrial function, offering a novel therapeutic strategy for conditions characterized by mitochondrial dysfunction and muscle decline. By improving …
This research powerfully highlights the graviola oil extract's potential as a natural, multi-faceted supplement for significantly enhancing livestock productivity and overall health. By effectively improving fattening…
This research highlights a novel role for MOTS-c in modulating adrenal gland metabolism, specifically by enhancing mitochondrial function and energy production without directly impacting steroid hormone synthesis. Thi…