188 studies on Mitochondrial peptide class curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This discovery represents a pivotal breakthrough in understanding the mechanism of action of SS-31, a drug with significant therapeutic potential across a range of mitochondrial dysfunction-related diseases. Identifyi…
These findings underscore SS-31's significant potential as a novel therapeutic agent for managing and treating inflammatory liver conditions. By elucidating its mechanism through ATG5-dependent autophagy, this researc…
This research highlights Elamipretide's significant potential as an additive to cryopreservation solutions, offering a novel strategy to mitigate cellular damage during ovarian tissue vitrification. By protecting mito…
This study highlights elamipretide's significant potential as a therapeutic agent for combating cognitive impairments associated with chronic sleep deprivation. Its ability to directly target and restore mitochondrial…
This study provides compelling evidence that MitoPeptide-X can effectively reverse skeletal muscle mitochondrial dysfunction and improve muscle performance in a preclinical model of metabolic disease. This identifies …
This research highlights SS-31 as a promising therapeutic candidate for Barth syndrome, directly targeting the mitochondrial dysfunction central to the disease's pathology. By ameliorating mitochondrial morphology and…
This research highlights SS-31's potential as a therapeutic agent for mitigating cellular damage caused by cigarette smoke, offering a novel approach to combat oral diseases. By targeting mitochondrial dysfunction and…
This extensive review highlights the critical and multifaceted role of mitochondrial dysfunction in driving the aging process and underscores the significant therapeutic potential of targeting these organelles. The co…
This review underscores the pivotal role of mitochondria in determining the trajectory of recovery and long-term neurological health after TBI. By identifying mitochondrial dysfunction as a key pathological mechanism,…
This discovery of SS-31-X represents a significant advancement in the development of mitochondrial-targeting therapeutics. The observed enhanced efficacy in protecting mitochondrial function and reducing oxidative str…
This research provides compelling evidence that SS-31 (elamipretide) is a highly promising therapeutic agent for treating diabetic cardiomyopathy. The identification of its mechanism of action, specifically through th…
The combination of H/R and SPIONs (50 µg/mL) significantly induced ferroptosis in cardiomyocytes, resulting in a 45% reduction in cell viability and a 2.8-fold increase in lipid peroxidation (MDA levels) compared to u…
This research highlights the critical role of mitochondrial health in mitigating the long-term debilitating effects of sepsis on muscle function. The findings suggest that targeting mitochondrial dysfunction could rep…
This study's findings are highly significant as they demonstrate a novel and effective therapeutic strategy that simultaneously targets multiple critical pathological mechanisms of Alzheimer's disease: mitochondrial d…
This study presents a highly promising regenerative strategy for intervertebral disc degeneration by directly targeting mitochondrial dysfunction, a fundamental cause of disc breakdown. The ability of the multifunctio…
This study provides compelling evidence that SS-31@Fer-1 can effectively prevent ferroptosis in heart cells following hypoxia/reoxygenation injury, offering a critical new strategy to reduce damage after events like h…
This research fundamentally shifts our understanding of how telomere length is established and inherited, demonstrating its modifiability during the earliest stages of embryonic development. The ability to intervene w…
This research underscores the critical importance of mitochondrial health in preventing age-related cerebral microhemorrhages, offering a highly promising therapeutic strategy. The findings suggest that SS-31 could em…
This research highlights the therapeutic potential of SS-31 as a novel treatment strategy for pulmonary fibrosis by targeting mitochondrial dysfunction and oxidative stress, key drivers of the disease. Given the curre…
This research provides crucial insights into the molecular mechanisms underlying angiotensin II-induced kidney damage, highlighting Sirt6 as a key regulator of lipid metabolism in podocytes. The findings suggest that …
This research provides crucial insights into the early molecular events following traumatic muscle injury, identifying acute mitochondrial ROS as a central player in the ensuing dysfunction. Targeting these early ROS …
This study provides compelling evidence that targeting mitochondrial dysfunction with MitoRenin can effectively reverse key pathological features of kidney disease progression, including both functional impairment and…
This research highlights SS-31 as a potent therapeutic candidate for combating age-related decline in bone formation by targeting mitochondrial health and NOS2 activity. The ability of SS-31 to restore mitochondrial f…
This research identifies YTHDF1 as a novel and critical regulator of allergic airway inflammation and mitochondrial dysfunction, offering a new perspective on asthma pathogenesis. By elucidating its interaction with t…
This research provides compelling evidence that mitochondrial dysfunction is a primary driver of age-related aortic degeneration. The successful intervention with elamipretide highlights its potential as a therapeutic…
This study provides compelling evidence that Szeto-Schiller 31 can effectively alleviate acute lung injury in neonatal mice by targeting critical inflammatory pathways. The ability of SS-31 to suppress TXNIP expressio…
This research highlights the critical importance of standardized and optimized quenching protocols in environmental water analysis. Inaccurate DBP profiles due to improper sample handling could lead to misjudgments of…
This case report, supported by existing evidence, suggests that elamipretide holds significant promise as a targeted therapy for Barth Syndrome, directly addressing the core mitochondrial dysfunction. The observed imp…
This study provides compelling evidence that patient self-selection for ream-and-run arthroplasty does not negatively influence postoperative outcomes, including pain, function, and satisfaction. This finding is signi…
This research highlights SS-31's novel mechanism of action in neuroprotection, specifically by targeting microglial ferroptosis and modulating their inflammatory state. The ability to shift microglia towards a protect…
This scoping review provides a crucial roadmap for future research by consolidating the diverse landscape of peptides being explored for skeletal muscle wasting. It highlights the significant therapeutic potential of …
This research provides strong evidence that mitochondrial dysfunction is a primary driver of aortic aging, offering a novel understanding of age-related cardiovascular decline. The successful restoration of mitochondr…
This research highlights the critical role of endothelial glycocalyx integrity in maintaining cognitive function during aging and suggests that SS-31 could be a promising therapeutic agent. By protecting the glycocaly…
This review underscores the transformative potential of nanoliposomal technology for improving human health by revolutionizing nutrient and drug delivery. By enhancing bioavailability and enabling targeted action, nan…
This study highlights SS-31's potential as a therapeutic agent for improving female fertility, particularly in cases of advanced maternal age. By directly targeting mitochondrial dysfunction, a central mechanism of oo…
This research is significant because it identifies hippocampal mitochondrial dysfunction as a central mechanism underlying opioid-induced postoperative cognitive dysfunction in aged individuals. By pinpointing specifi…
Understanding the evolutionary history and selective pressures on humanin and SHLP6 provides crucial insights into their functional significance and potential roles in health and disease. The identification of sites u…
This study provides compelling evidence that circulating MOTS-c levels are significantly associated with both metabolic health and the severity of liver fibrosis in patients with MAFLD. The consistent inverse relation…
This research uncovers a novel antiviral mechanism for MOTS-c, demonstrating its potent ability to combat HBV infection by modulating mitochondrial dynamics. This unique approach could offer a significant advantage ov…
These findings are significant because they identify MOTS-c as a potential biomarker for lower-body muscle strength, independent of aerobic fitness. This specificity could make MOTS-c a valuable tool for assessing mus…
The findings suggest that MOTS-c holds significant promise as a novel therapeutic agent for managing inflammatory pain, leveraging its ability to act on both central and peripheral pain pathways. This dual mechanism o…