272 studies on Ghrelin mimetic class curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This research highlights a novel role for ghrelin in modulating gut-brain communication, specifically its ability to dampen autonomic responses to stomach distension. This mechanism could be therapeutically exploited …
This study successfully demonstrates the synthesis of novel azapeptides that effectively modulate the CD36 receptor, highlighting their potential as a new class of therapeutic agents. The observed improvements in lipi…
This research highlights the significant atheroprotective and atheroregressive potential of novel azapeptide derivatives, offering a new therapeutic strategy beyond traditional lipid-lowering approaches. By selectivel…
This research highlights a novel role for the ghrelin receptor system in modulating opioid tolerance, suggesting that targeting these receptors could offer a new therapeutic strategy. Attenuating morphine tolerance co…
This research highlights the potential of ghrelin antagonists as therapeutic targets for managing conditions characterized by excessive hunger or metabolic dysregulation. By demonstrating that blocking ghrelin can mod…
Understanding the precise molecular interactions between these novel peptides and the ghrelin receptor is critical for rational drug design. This in silico strategy provides a powerful framework for optimizing existin…
This study establishes a robust and efficient theoretical model for ultra-fast calculation of electronic excitation spectra in large systems like proteins and other biomacromolecules. The combination of high accuracy …
This research highlights acylated ghrelin's potential as a potent renoprotective agent against chemotherapy-induced kidney damage. By activating SIRT1, a protein involved in cellular health and longevity, ghrelin appe…
This study identifies a crucial role for central CRF1 receptor signaling in regulating glucose homeostasis during periods of calorie restriction, mediated through ghrelin. Understanding this pathway could open new ave…
This study provides compelling evidence that Ghrelin can protect intestinal epithelial cells from apoptosis in Ulcerative Colitis by activating the Unfolded Protein Response (UPR) pathway. This identifies a novel ther…
This research highlights acylated ghrelin's significant potential as a therapeutic agent for mitigating cardiac damage caused by excessive thyroid hormones. Its ability to simultaneously combat oxidative stress, reduc…
These findings are highly significant as they identify Ghrelin as a potential therapeutic agent for the cognitive deficits associated with depression, a symptom often resistant to conventional treatments. The elucidat…
This study's elucidation of the atomic-level molecular recognition of ghrelin by its receptor provides invaluable structural templates that are poised to revolutionize rational drug design. By understanding exactly ho…
This research highlights the ghrelin-GOAT system as a critical modulator of food reward and motivation, offering a promising new therapeutic target for eating disorders. By specifically inhibiting GOAT, it's possible …
This research significantly expands our understanding of ghrelin's multifaceted roles, particularly its critical involvement in energy conservation and thermoregulation during periods of nutritional stress. The abilit…
This research uncovers a novel and significant role for Growth hormone secretagogue peptide-6 (GHS-6) as a potent immunomodulator in fish, specifically by enhancing the production of antimicrobial peptides. The findin…
This research highlights a novel therapeutic strategy: targeting the ghrelin signaling pathway to enhance the success of islet transplantation. By improving graft survival and function, this approach could significant…
This research highlights the therapeutic potential of ghrelin receptor antagonism in mitigating the adverse physiological and behavioral responses associated with immune challenges. By effectively reducing sickness be…
This study reveals a critical and previously underappreciated role for the ghrelin receptor type 1a (GHSR1a) in modulating seizure susceptibility and severity within the brain. The finding that GHSR1a antagonism drama…
This research provides a mechanistic understanding of how enteral nutrition combats hypercatabolism, highlighting the critical role of the ghrelin/GHS-R1α-POMC pathway. The findings suggest that optimizing enteral fee…
This research highlights Meranzin Hydrate's potential as a novel therapeutic agent for depression and associated motor deficits, acting through the ghrelin system and neuroplasticity pathways. The findings suggest a p…
This research uncovers a novel mechanism by which oral L-ornithine stimulates growth hormone (GH) secretion, specifically implicating ghrelin receptor-mediated pathways. Understanding this interaction could open new a…
This study provides compelling evidence that targeting ghrelin receptors in the brain offers a novel therapeutic strategy for NAFLD and associated metabolic dysfunctions. By improving hypothalamic insulin resistance, …
This research provides compelling evidence that ghrelin acts as a potent pro-angiogenic factor, directly stimulating new blood vessel formation in human heart cells under oxygen-deprived conditions. This finding is hi…
This study provides critical insights into the metabolic regulatory functions of ghrelin, particularly its role in modulating liver fat and glucose metabolism. The findings suggest that ghrelin's normal activity might…
This groundbreaking study offers vital new insights into the complex neurobiological underpinnings of nicotine addiction, highlighting the previously underappreciated role of ghrelin, a peptide hormone known for its i…
This research highlights the critical importance of ghrelin balance for successful embryo implantation and pregnancy outcomes, extending its known roles beyond metabolism. Understanding how ghrelin misbalance disrupts…
This research highlights ghrelin's potential as a therapeutic agent for managing GDM by targeting the underlying mechanism of ER stress. By mitigating ER stress in placental cells and improving glucose metabolism, ghr…
This study highlights Ghrelin's significant potential as a therapeutic agent for preventing or treating intestinal ischemia-reperfusion injury. By modulating the GHSR-1α/Sirt1/FOXO1 pathway, Ghrelin offers a novel and…
This research highlights GHRP-6 as a promising therapeutic agent to protect against the severe organ damage caused by doxorubicin chemotherapy. By activating intrinsic prosurvival mechanisms, GHRP-6 could potentially …
This research highlights ghrelin as a potential therapeutic agent for combating pancreatic β-cell dysfunction and apoptosis, which are central to the progression of type 2 diabetes. By targeting ER stress and the IRE1…
This groundbreaking research provides a fundamental and unprecedented understanding of how ghrelin directly influences cellular excitability and signaling by precisely modulating VGCCs. This direct molecular interacti…
The study yielded compelling evidence that ghrelin is indeed indispensable for the characteristic blood pressure reduction during torpor. A striking difference was observed: ghrelin-deficient mice exhibited a signific…
This study provides compelling evidence that intranasal delivery is a viable and effective route for engaging the brain's ghrelin signaling system. This non-invasive approach could circumvent the challenges of systemi…
This study highlights a novel therapeutic target for managing the challenging symptoms of nicotine withdrawal. By demonstrating that Ghrelin and GHRP-6 can significantly reduce withdrawal-induced hyperactivity, these …
This study provides crucial preclinical safety data, strongly supporting the continued development of CIGB-500 as a potential therapeutic agent. The robust safety profile observed in beagle dogs at high doses, includi…
This study provides compelling evidence for ghrelin's ability to promote significant neurological recovery and neurogenesis in the chronic phase after stroke. Its capacity to stimulate new neuron formation and improve…
This research highlights Danshen-Chuanxiong-Honghua (DCH) as a promising multi-target therapeutic agent for traumatic brain injury, offering both anti-inflammatory and neuroprotective benefits. The specific identifica…
This research highlights the significant potential of GHRP-6 as a functional feed additive in aquaculture, offering a novel strategy to enhance both growth performance and disease resistance in farmed fish. The abilit…
This research provides compelling evidence for the potential of GHRP-6 as a novel therapeutic agent to enhance human oocyte quality and maturation, which could significantly improve success rates for infertility treat…