116 studies on TNF-α mechanism curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This research highlights Growth Hormone Releasing Peptide-2 (GHRP-2) as a promising therapeutic candidate for Acute Lung Injury (ALI), a condition with high morbidity and mortality and limited treatment options. The o…
This research highlights GHRP-2 as a potential novel therapeutic agent for mitigating ovarian inflammation, which could have significant implications for treating conditions like PCOS or improving fertility outcomes. …
This study provides compelling evidence that GHRH analogs possess significant anti-inflammatory, antioxidant, and beneficial behavioral properties, extending their therapeutic potential beyond endocrine regulation. Th…
This research identifies LAPTM5 as a novel and critical regulator of the STING pathway in the context of rosacea, offering a new perspective on the disease's pathogenesis. The findings suggest that targeting LAPTM5 co…
This research highlights a promising strategy to create more durable and infection-resistant dental implants. By leveraging the natural antimicrobial and pro-healing properties of LL-37, these biofunctionalized implan…
This systematic review underscores the critical role of genetic factors in modulating inflammatory responses in periodontitis, especially in individuals with underlying genetic or immunological disorders. Understandin…
This research highlights cathelicidin's potential as a therapeutic agent for neuroinflammatory conditions by targeting the gut-brain axis. The ability of cathelicidin to simultaneously reduce gut permeability and brai…
This research presents a highly promising strategy for treating difficult-to-manage infected skin wounds, particularly those resistant to conventional antibiotics. The injectable, self-healing nature of the hydrogel e…
This comprehensive study provides a strong scientific basis for the traditional use of Cuochuangling Pills in treating rosacea, elucidating its multi-target anti-inflammatory and antioxidant mechanisms. The identifica…
This study provides compelling in vitro evidence that a novel food supplement combining postbiotics and plant-derived compounds can directly strengthen the intestinal barrier and promote a balanced immune response. Th…
This research provides critical insights into the complex interplay between host defense peptides and bacterial components within the oral biofilm, highlighting a previously unrecognized mechanism by which LL-37 might…
These findings highlight the significant potential of alpha-MSH peptides, particularly potent analogs like NDP-MSH, as a novel class of antimicrobial agents with a dual mechanism of action: direct bacterial killing an…
This research highlights the significant potential of alpha-MSH peptides as novel therapeutic agents for HIV-1 infection, particularly given their ability to modulate inflammation and directly suppress viral activity.…
This research highlights KPV as a promising therapeutic agent for intestinal inflammatory diseases due to its ability to be actively absorbed and exert potent anti-inflammatory effects. Its dual action of suppressing …
This research significantly broadens our understanding of α-MSH's complex anti-inflammatory mechanisms, indicating that its therapeutic potential extends beyond the well-characterized pharmacophore and melanocortin re…
This research highlights PepT1 as a critical driver in the pathogenesis of colitis-associated cancer, suggesting it could be a novel diagnostic biomarker and a promising therapeutic target. The significant anti-tumor …
This study presents a highly promising and effective targeted oral delivery system for KPV, a potent anti-inflammatory tripeptide, directly to the inflamed colon. The innovative use of hyaluronic acid-functionalized n…
This study highlights the significant potential of advanced drug delivery systems to substantially enhance the therapeutic efficacy of existing peptides like KPV for chronic inflammatory conditions. By improving both …
This research highlights the therapeutic potential of novel peptides in modulating immune cell function, offering a promising avenue for treating conditions characterized by excessive inflammation and cell proliferati…
This study provides crucial insights into the molecular mechanisms underlying Semax's neuroprotective effects by demonstrating its ability to modulate gene expression related to inflammation and vascular repair after …
This study provides critical molecular evidence supporting ACTH's neuroprotective role by elucidating its impact on the brain's protein landscape. The upregulation of neurotrophic factors like BDNF and downregulation …
This study's findings are significant because they suggest synthetic ACTH peptides could be a novel therapeutic strategy to mitigate detrimental neuroinflammation after stroke. By shifting the immune response towards …
This research uncovers a novel mechanism by which Semax peptide promotes recovery after spinal cord injury, specifically through targeting the Oprm1 gene and enhancing deubiquitination, a process crucial for protein s…
This research provides compelling evidence that Selank possesses potent immunomodulatory properties, extending beyond its known neurological effects, by directly influencing the transcriptional activity of key inflamm…
Selank's ability to normalize cytokine profiles under social stress conditions suggests its potential as a novel therapeutic agent for stress-related inflammatory disorders. This immunomodulatory effect could be parti…
This study highlights MOTS-c as a crucial mediator of the cardioprotective effects of aerobic exercise in diabetic myocardial injury, primarily through enhancing antioxidant defense. The findings suggest that targetin…
This study identifies MOTS-c as a promising novel therapeutic agent for cancer-induced bone pain, addressing a significant unmet medical need in oncology. Its unique mechanism through AMPK-mediated mitochondrial bioge…
This groundbreaking research highlights MOTS-c as a highly promising novel therapeutic agent for the prevention and treatment of radiation pneumonitis. Its ability to simultaneously modulate inflammation, reduce oxida…
This study provides a robust mechanistic framework for understanding how MOTS-c protects the brain after traumatic injury, highlighting its role in enhancing mitochondrial function and reducing inflammation and oxidat…
The most significant finding was that MOTS-c administration achieved comparable or superior protective effects to remote ischemic preconditioning in mitigating lung ischemia-reperfusion injury, reducing tissue damage …
This research highlights MOTS-c as a promising novel therapeutic agent for preventing or treating CPB-induced acute lung injury. By promoting glycolysis through the AMPK-HIF-1α-PFKFB3 pathway, MOTS-c offers a unique m…
This research highlights MOTS-c as a promising therapeutic candidate for mitigating sepsis-associated brain injury by directly targeting the blood-brain barrier. The ability of MOTS-c to preserve BBB integrity and red…
This research highlights MOTS-c as a promising therapeutic candidate for preventing or treating acute liver injury caused by acetaminophen overdose. Its ability to modulate the MAPK signaling pathway and reduce both n…
This review significantly advances our understanding of the multifaceted nature of obesity, providing a robust framework for developing more effective and personalized treatments. The detailed exploration of molecular…
This research highlights the potent renoprotective capabilities of multi-agonist incretin therapies, particularly Retatrutide, in managing Diabetic Kidney Disease. The superior efficacy of Retatrutide, which targets G…
This groundbreaking research powerfully highlights the potential of Thymosin alpha 1 as a novel and effective therapeutic agent for addressing the complex systemic complications of cystic fibrosis, offering a much-nee…
This study provides crucial insights into the gender-specific immune dysregulation observed in COVID-19, highlighting lower T-cell counts and higher inflammation in males. The finding that males with severe disease al…
This study provides compelling in vitro evidence that Thymosin Alpha 1 can effectively mitigate the cytokine storm observed in COVID-19 patients at a cellular level. The ability to dampen excessive inflammation withou…
This study provides compelling evidence that Thymosin α1, an immunomodulatory peptide, can significantly improve survival and immune function in patients with HBV-related ACLF, a condition with historically poor progn…
This study provides compelling evidence that combining Thymosin α1 with blood purification offers a promising new therapeutic strategy for managing severe shock, potentially leading to a significant reduction in patie…
This research provides compelling evidence that Thymosin α1 possesses significant immunomodulatory properties that could be highly beneficial in managing SARS-CoV-2 infection. By dampening the excessive inflammatory r…
This study provides compelling evidence that Thymosin alpha 1 can effectively restore critical aspects of immune homeostasis in patients suffering from Long COVID. The observed improvements in T cell subsets, reductio…
This research highlights a novel strategy to overcome a significant hurdle in oncolytic adenovirus (OAV) therapy: the immunosuppressive tumor microenvironment. Thymosin α1's ability to reprogram M2 macrophages into an…
This research provides compelling in vitro evidence for the direct anti-proliferative effects of Thymosin Alpha 1 on various cancer cell lines and its potent ability to activate key immune cell subsets. The key implic…
The development of Refnot represents a significant advancement, offering a novel and potentially safer strategy to combat the multifaceted challenges of age-related immune decline and chronic inflammation. By combinin…
This research highlights the significant potential of Thymosin Alpha 1 (Tα1) as an immunotherapeutic agent to overcome T cell exhaustion in chronic diseases. The observed 'reset' of CD8 T cells suggests Tα1 could be a…
These findings are highly significant as they demonstrate that GHK-Cu possesses a potent protective effect in LPS-induced acute lung injury by inhibiting excessive inflammatory responses and oxidative stress. This sug…
This study highlights the significant potential of copper peptide-functionalized biomimetic hydrogels to overcome the challenges of chronic diabetic wounds. By promoting angiogenesis, collagen synthesis, and reducing …
These findings are highly significant as they demonstrate that GHK peptide can effectively combat age-related cognitive decline through a non-invasive delivery method. This suggests GHK peptide represents a promising …
This study provides compelling evidence that GHK-Cu possesses significant anti-inflammatory, tissue-repairing, and gut barrier-enhancing properties in an experimental model of colitis. These findings suggest its stron…