194 studies on Oxidative stress mechanism curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This study provides compelling evidence that passive smoking significantly impairs oral health in children, not only by exacerbating oxidative stress but also by compromising crucial innate immune defenses. The findin…
This review significantly advances our understanding of bioactive antioxidant peptides as promising natural agents for preventing and managing cardiometabolic disorders. By elucidating their multi-target mechanisms, i…
This research highlights MOTS-c as a promising therapeutic candidate for conditions involving impaired spermatogenesis. By targeting SLC7A11 and suppressing ferroptosis, MOTS-c offers a novel mechanism to protect germ…
This research is significant because it elucidates a novel and potent mechanism of action for cathelicidin peptides against multidrug-resistant A. baumannii, specifically targeting the bacterial respiratory chain. By …
SS-31 represents a highly promising therapeutic strategy for a wide range of conditions characterized by mitochondrial dysfunction, offering a direct and targeted approach to cellular protection. Its unique ability to…
The premature termination of this study represents a missed opportunity to gather crucial data on the potential benefits of high-dose Vitamin D3 for immune enhancement in HIV+ individuals and smokers. Had it been comp…
The ability to accurately predict cardiovascular mortality in Type 2 Diabetes Mellitus patients with Coronary Artery Disease is paramount for enhancing patient care and improving long-term outcomes. Positive findings …
This study provides compelling evidence that modified C-terminal apelin fragments possess significant cardiometabolic and antioxidant properties, offering a novel therapeutic avenue for treating cardiac pathologies. T…
This study provides compelling evidence that SS-31 peptide can mitigate severe cardiac mitochondrial dysfunction in a genetic model of Barth syndrome, suggesting its potential as a novel therapeutic strategy. By impro…
This review highlights the critical role of mitochondrial health in NAFLD pathogenesis and underscores the immense potential of mitochondrial-targeted therapies. By summarizing the efficacy of various compounds and me…
This research highlights SS-31 as a promising therapeutic agent for combating age-related cerebrovascular dysfunction by directly targeting mitochondrial health. The observed proteomic improvements suggest that SS-31 …
This research provides compelling evidence for Elamipretide's therapeutic potential in treating Idiopathic Pulmonary Fibrosis by targeting a crucial inflammatory and fibrotic pathway. The ability of Elamipretide to mo…
The successful application of SS-31 as a mitochondrial-targeted antioxidant represents a significant advancement in therapeutic strategies for diseases driven by mitochondrial pathology. By directly addressing the roo…
This research highlights mitochondrial ROS as a crucial mechanistic driver of calcium alternans in atrial myocytes, offering a novel perspective on the pathogenesis of atrial fibrillation (AF). The findings suggest th…
This research highlights SS-31 as a promising therapeutic candidate for hepatic fibrosis by simultaneously targeting mitochondrial dysfunction and NLRP3 inflammasome-mediated inflammation. The ability of SS-31 to dire…
This research highlights Elamipretide's significant potential as an additive to cryopreservation solutions, offering a novel strategy to mitigate cellular damage during ovarian tissue vitrification. By protecting mito…
This study highlights elamipretide's significant potential as a therapeutic agent for combating cognitive impairments associated with chronic sleep deprivation. Its ability to directly target and restore mitochondrial…
This research highlights SS-31 as a promising therapeutic candidate for Barth syndrome, directly targeting the mitochondrial dysfunction central to the disease's pathology. By ameliorating mitochondrial morphology and…
This research highlights SS-31's potential as a therapeutic agent for mitigating cellular damage caused by cigarette smoke, offering a novel approach to combat oral diseases. By targeting mitochondrial dysfunction and…
This extensive review highlights the critical and multifaceted role of mitochondrial dysfunction in driving the aging process and underscores the significant therapeutic potential of targeting these organelles. The co…
This review underscores the pivotal role of mitochondria in determining the trajectory of recovery and long-term neurological health after TBI. By identifying mitochondrial dysfunction as a key pathological mechanism,…
This discovery of SS-31-X represents a significant advancement in the development of mitochondrial-targeting therapeutics. The observed enhanced efficacy in protecting mitochondrial function and reducing oxidative str…
This research provides compelling evidence that SS-31 (elamipretide) is a highly promising therapeutic agent for treating diabetic cardiomyopathy. The identification of its mechanism of action, specifically through th…
The combination of H/R and SPIONs (50 µg/mL) significantly induced ferroptosis in cardiomyocytes, resulting in a 45% reduction in cell viability and a 2.8-fold increase in lipid peroxidation (MDA levels) compared to u…
This research highlights the critical role of mitochondrial health in mitigating the long-term debilitating effects of sepsis on muscle function. The findings suggest that targeting mitochondrial dysfunction could rep…
This study's findings are highly significant as they demonstrate a novel and effective therapeutic strategy that simultaneously targets multiple critical pathological mechanisms of Alzheimer's disease: mitochondrial d…
This study presents a highly promising regenerative strategy for intervertebral disc degeneration by directly targeting mitochondrial dysfunction, a fundamental cause of disc breakdown. The ability of the multifunctio…
This study provides compelling evidence that SS-31@Fer-1 can effectively prevent ferroptosis in heart cells following hypoxia/reoxygenation injury, offering a critical new strategy to reduce damage after events like h…
This research underscores the critical importance of mitochondrial health in preventing age-related cerebral microhemorrhages, offering a highly promising therapeutic strategy. The findings suggest that SS-31 could em…
This research highlights the therapeutic potential of SS-31 as a novel treatment strategy for pulmonary fibrosis by targeting mitochondrial dysfunction and oxidative stress, key drivers of the disease. Given the curre…
This research provides crucial insights into the early molecular events following traumatic muscle injury, identifying acute mitochondrial ROS as a central player in the ensuing dysfunction. Targeting these early ROS …
This research highlights SS-31 as a potent therapeutic candidate for combating age-related decline in bone formation by targeting mitochondrial health and NOS2 activity. The ability of SS-31 to restore mitochondrial f…
This research identifies YTHDF1 as a novel and critical regulator of allergic airway inflammation and mitochondrial dysfunction, offering a new perspective on asthma pathogenesis. By elucidating its interaction with t…
This study provides compelling evidence that Szeto-Schiller 31 can effectively alleviate acute lung injury in neonatal mice by targeting critical inflammatory pathways. The ability of SS-31 to suppress TXNIP expressio…
This case report, supported by existing evidence, suggests that elamipretide holds significant promise as a targeted therapy for Barth Syndrome, directly addressing the core mitochondrial dysfunction. The observed imp…
This review underscores the transformative potential of nanoliposomal technology for improving human health by revolutionizing nutrient and drug delivery. By enhancing bioavailability and enabling targeted action, nan…
This study highlights SS-31's potential as a therapeutic agent for improving female fertility, particularly in cases of advanced maternal age. By directly targeting mitochondrial dysfunction, a central mechanism of oo…
This research is significant because it identifies hippocampal mitochondrial dysfunction as a central mechanism underlying opioid-induced postoperative cognitive dysfunction in aged individuals. By pinpointing specifi…
These findings are highly significant as they demonstrate that Ghrelin acts as a potent neuroprotective agent against HIE-induced brain injury by modulating oxidative stress and neuronal apoptosis. The elucidation of …
This research highlights acylated ghrelin's potential as a potent renoprotective agent against chemotherapy-induced kidney damage. By activating SIRT1, a protein involved in cellular health and longevity, ghrelin appe…
This research highlights acylated ghrelin's significant potential as a therapeutic agent for mitigating cardiac damage caused by excessive thyroid hormones. Its ability to simultaneously combat oxidative stress, reduc…
This research highlights the critical importance of ghrelin balance for successful embryo implantation and pregnancy outcomes, extending its known roles beyond metabolism. Understanding how ghrelin misbalance disrupts…
This study highlights Ghrelin's significant potential as a therapeutic agent for preventing or treating intestinal ischemia-reperfusion injury. By modulating the GHSR-1α/Sirt1/FOXO1 pathway, Ghrelin offers a novel and…