636 studies on GLP-1 agonist class curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This review underscores the increasing importance of real-world evidence (RWE) in shaping healthcare decisions, from reimbursement to regulatory approval. By demonstrating how RWE is being effectively utilized and ide…
This research is highly significant as it identifies semaglutide as a promising novel candidate for treating cocaine use disorder. Given the severe lack of effective pharmacological interventions for addiction, these …
This commentary underscores the urgent need for a proactive public health strategy to manage the societal implications of GLP-1RA proliferation. The authors argue that without clear guidelines and public education, th…
The widespread use of GLP-1 RAs for managing diabetes and obesity makes understanding their perioperative implications critically important for patient safety. This study directly addresses the potential for increased…
As this study is currently "NOT_YET_RECRUITING" and is scheduled to begin in 2026, no results or specific data are available at this time. The primary objective is to determine if there are significant differences in …
This study is crucial because it seeks to uncover a novel mechanism by which semaglutide promotes weight loss, specifically through its impact on brown adipose tissue (BAT). Understanding this pathway could lead to mo…
This study holds significant promise for overweight and obese women struggling with infertility, potentially offering a novel therapeutic strategy to improve IVF success rates. If Semaglutide pre-treatment proves effe…
This diagnostic study, while listed as completed, has not yet published its specific findings regarding gastric contents in patients on semaglutide, with the official completion date set for 2025-05-31. However, the f…
Optimizing early T2DM management is crucial for preventing long-term complications and improving patient quality of life. This trial could provide critical evidence for the benefits of aggressive, early combination th…
This study is significant because it provides valuable real-world evidence on Semaglutide's effectiveness, complementing the data from highly controlled clinical trials. Understanding how a drug performs in diverse pa…
Understanding tirzepatide's effects on skeletal muscle is critically important, as preserving muscle mass during weight loss is a key challenge, especially in obesity. If tirzepatide can mitigate muscle loss or even i…
This study is crucial for understanding Tirzepatide's long-term efficacy and safety outside of highly controlled clinical trial environments. If successful, the findings could significantly inform clinical guidelines …
Semaglutide is currently not FDA-approved for Type 1 Diabetes, making this research critical for exploring new therapeutic avenues in a population with significant unmet medical needs. If the trial demonstrates positi…
Understanding GIP's long-term effects on bone is critically important given the widespread use of GIP receptor (GIPR) agonists like tirzepatide for obesity and type 2 diabetes, conditions often associated with comprom…
This study holds significant promise as it could identify a new, effective pharmacological treatment for severe forms of obesity like Prader-Willi Syndrome and hypothalamic obesity, which currently have limited therap…
This study is crucial as it addresses a significant unmet need for effective anti-obesity treatments in adult congenital heart disease (ACHD) patients, a population often excluded from major clinical trials. If succes…
The successful demonstration of semaglutide's safety and tolerability in CFRD patients would be a significant step forward, potentially offering a novel therapeutic avenue beyond insulin. If proven safe and effective …
This two-year study is crucial for understanding the long-term effectiveness and safety of Semaglutide as a treatment for overweight and obesity. If the results demonstrate sustained weight loss and a favorable safety…
Understanding how liver function affects oral semaglutide's pharmacokinetics is crucial for dose adjustments and patient safety, especially given the widespread use of GLP-1 receptor agonists for type 2 diabetes. The …
This study holds significant promise for addressing a critical unmet medical need: effective treatment for early-onset, treatment-resistant obesity in young adults. If successful, the RESETTLE Study could establish se…
The discontinuation of GLP-1 agonists often leads to weight regain and a return of metabolic challenges, including elevated triglycerides, which are risk factors for cardiovascular disease. If RDX-002 proves effective…
This ongoing trial is crucial because it addresses a significant unmet medical need, potentially offering a new therapeutic option for adolescent obesity. If successful, the findings could establish tirzepatide as a s…
The study, currently underway, aims to demonstrate the significant efficacy of Tirzepatide in reducing liver fat deposition in patients with Type 2 Diabetes and NAFLD with advanced fibrosis. Based on Tirzepatide's wel…
This research is critically important as it will provide evidence-based guidance for managing incretin-based therapies in patients undergoing upper endoscopy, potentially enhancing patient safety and procedural effici…
This review highlights that obesity pharmacotherapy should be considered a disease-modifying component of Type 2 Diabetes (T2D) care, moving beyond mere weight reduction. The ability of these drugs to improve a broad …
This comprehensive 'Trial Watch' is crucial for understanding the evolving landscape of MASH treatment and identifying the most promising therapeutic avenues. It provides invaluable insights for clinicians, researcher…
This case report is highly significant as it identifies a potential rare but serious adverse event associated with tirzepatide use in a patient population not traditionally considered at high risk for ketoacidosis. It…
The pervasive and devastating impact of addiction, affecting billions globally and incurring significant health, social, and economic costs, underscores the critical need for innovative treatment strategies. Incretin-…
A deeper understanding of the precise mechanisms underlying beta-cell stress and identity failure is absolutely crucial for the development of novel, disease-modifying therapeutic strategies for type 2 diabetes. This …
This case, if substantiated by detailed clinical data, suggests that Semaglutide could represent a novel and effective therapeutic option for patients with Ulcerative Colitis, particularly those who also suffer from o…
This case report is highly significant given the rapidly expanding use of semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, including its off-label use for weight loss. This finding suggests a potential…