1 study on Sphk1 mechanism curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
**SphK1-derived S1P is the 'missing link' through which IGFBP-3 amplifies both IGF and EGF receptor signaling**, reframing IGFBP-3 not merely as an IGF carrier but as an active lipid-signaling inducer. For researchers…