24 studies on Pi3k akt mechanism curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This study provides compelling preclinical evidence that semaglutide, a widely used GLP-1 receptor agonist for type 2 diabetes and obesity, possesses significant neuroprotective properties against chemotherapy-induced…
This research identifies MLPH as a novel and potent regulator of human hair growth, acting directly on the critical IGF-1 signaling pathway within the dermal papilla. Understanding this mechanism provides a new therap…
This research highlights NDP-MSH as a promising therapeutic candidate for treating intracerebral hemorrhage by targeting multiple pathways involved in secondary brain injury. By activating the Melanocortin-1 Receptor …
This research provides compelling evidence that cellular senescence in adipocytes directly contributes to insulin resistance, offering a novel mechanistic link between aging and metabolic disease. The findings suggest…
This research highlights ARA290 as a promising neuroprotective agent that directly safeguards brain tissue from the devastating effects of ischemic stroke. By targeting the β-common receptor, ARA290 offers a novel mec…
This research positions kisspeptins as a highly promising new therapeutic candidate for the treatment of endometriosis. By simultaneously targeting both the invasion of endometrial cells and the angiogenesis that fuel…
This research highlights Kisspeptin-10's significant potential as a therapeutic agent for addressing infertility and various reproductive disorders. By elucidating the involvement of the PI3K/AKT/ERK signaling pathway…
This research provides novel and critical mechanistic insights into how IGFBP-3 modulates cellular responses to growth factors, unequivocally identifying sphingosine kinase as a pivotal downstream effector in this pro…
This research provides compelling evidence that GH and IGF-I can effectively counteract the decline in milk production during prolonged lactation, suggesting new avenues for intervention. The distinct yet complementar…
This research highlights the fundamental importance of N-linked glycosylation for optimal IGF-1 signaling, providing crucial insights into cell biology and receptor function. Given that CHO cells are the primary indus…
This study provides compelling evidence for hexarelin's potential as a novel therapeutic agent for ischemic heart failure by beneficially modulating the PTEN/Akt/ERK signaling pathway. The observed significant improve…
This research highlights Hexarelin's significant neuroprotective potential against oxidative stress, a fundamental process implicated in numerous neurodegenerative conditions. By elucidating its mechanism through the …
The findings of this study compellingly demonstrated that <b>electroacupuncture</b> treatment conferred a <b>significant</b> and <b>robust</b> alleviation of <b>learning</b> and <b>memory impairment</b> in the <b>post…
This research provides critical foundational data for developing PULMO-Modulin as a potential inhaled therapeutic for pulmonary diseases where cAMP modulation is beneficial, such as asthma or COPD. The favorable bioph…
This research highlights a novel, non-glycemic benefit of Tirzepatide, suggesting its potential beyond glucose and weight management. The ability of Tirzepatide to significantly enhance angiogenesis and improve blood …
This review significantly advances our understanding of GLP-1's extensive therapeutic potential, moving beyond its established role in metabolic health. The detailed exploration of its neuroprotective mechanisms sugge…
This research highlights hUCB-MSCs as a promising therapeutic strategy for mitigating core symptoms of Autism Spectrum Disorder. The identification of the IGF-1/Akt signaling pathway as a key mechanism provides valuab…
This research highlights Acylated Ghrelin as a promising therapeutic agent to prevent or reduce doxorubicin-induced cardiotoxicity. By targeting the Fas/FasL apoptotic pathway and enhancing SERCA2a activity, it offers…
This research highlights ghrelin's potential as a therapeutic agent for managing GDM by targeting the underlying mechanism of ER stress. By mitigating ER stress in placental cells and improving glucose metabolism, ghr…
This research highlights GHRP-6 as a promising therapeutic agent to protect against the severe organ damage caused by doxorubicin chemotherapy. By activating intrinsic prosurvival mechanisms, GHRP-6 could potentially …
This study provides compelling evidence that GHRH antagonists possess significant antiproliferative and pro-apoptotic effects on ovarian cancer cells by targeting the EGFR-Akt signaling pathway. This discovery highlig…
This research is significant because enhanced proteolytic stability is a critical factor for improving the pharmacokinetic profile and therapeutic efficacy of peptide-based drugs like Semax. By identifying specific N-…
This research provides novel insights into the neuroprotective mechanisms of Semaglutide, demonstrating its ability to combat obesity-linked neurodegeneration by modulating microglia activation and AD-like pathology t…
The findings from this study are highly significant, as they demonstrate that GHK-Cu possesses potent anti-cachectic properties, effectively preserving muscle mass and improving muscle function in a preclinical model.…