3 studies on G protein coupled receptor mechanism curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
**The existence of a deeply conserved GHS-R strongly supports the eventual identification of an endogenous ghrelin-axis ligand**, providing a rational pharmacological target for reversing age-related GH decline. For c…
**The identification of `GPR38` as a GHS-R family member with motilin as its ligand** reveals that GH secretagogue pharmacology is entangled with gut-motility signaling — a consideration for clinicians and researchers…
**The ago-allosteric model for MK-677 and GHRP-6 is not supported in this assay system** — meaning assumptions about synergistic or supra-additive effects when combining ghrelin-pathway compounds with these secretagog…