484 studies on Insulin curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This case report provides compelling evidence that oral semaglutide could be a highly effective and well-tolerated treatment option for patients with HNF4A-MODY, potentially offering a valuable alternative to traditio…
This case report holds significant clinical importance as it expands the known adverse event profile of Tirzepatide, alerting clinicians to the possibility of drug-induced liver injury. While such events are rare, rec…
If successful, this study could highlight a novel therapeutic benefit of semaglutide beyond its established roles in glycemic control and weight management. Identifying an effective pharmacological intervention for di…
While specific numerical outcomes from this completed trial (NCT03882970) are not detailed in the provided record, the study's primary objective was to demonstrate the superior efficacy of tirzepatide in improving gly…
This research holds significant promise as tirzepatide could represent an innovative approach to effectively induce weight loss and inhibit tumor growth in obesity-driven endometrial cancer. Given the strong link betw…
This review significantly advances our understanding of bioactive antioxidant peptides as promising natural agents for preventing and managing cardiometabolic disorders. By elucidating their multi-target mechanisms, i…
This research highlights the immense potential of bioengineered spider silk as a versatile and robust platform for targeted and sustained delivery of therapeutic ligands. The ability to precisely activate GPCRs with p…
This research unveils a highly promising and novel strategy to significantly enhance the survival and long-term function of transplanted stem cell-derived islets. By specifically targeting zinc transport to pre-condit…
This review underscores the profound and expanding therapeutic potential of GLP-1 receptor agonists, solidifying their role as cornerstone treatments for type 2 diabetes and obesity. The confirmed cardiovascular and r…
This case report is significant because it raises awareness of a potentially novel adverse event associated with tirzepatide, a widely used and highly effective medication. If a causal link were established, it would …
If GHRH were found to be effective, this research could pave the way for a novel therapeutic strategy to address age-related sleep disturbances, a widespread issue affecting millions. Successfully augmenting the GH-IG…
This review provides crucial evidence to guide clinical decision-making and optimize the allocation of these highly effective therapies, especially in healthcare systems facing resource constraints. By identifying spe…
The intent behind this study highlights a critical challenge in endocrinology: the potential for significant inter-assay variability to compromise the accurate diagnosis and management of Growth Hormone (GH) disorders…
The intent behind this withdrawn study highlights a critical unmet need: finding effective treatments for sleep-disordered breathing in patients with lipodystrophy. If Tesamorelin could demonstrably improve sleep apne…
This foundational Phase 1 study is critical because it provides essential data on how Tesamorelin behaves in HIV positive patients, a population with unique metabolic considerations. The successful characterization of…
Understanding Tesamorelin's short-term effects in healthy individuals is crucial for broadening its potential therapeutic applications beyond HIV-associated lipodystrophy. If Tesamorelin can safely enhance GH secretio…
The investigation into TH9507, a growth hormone-releasing factor (GRF) analogue, represents an important step in exploring novel therapeutic strategies for Type 2 Diabetes. GRF plays a role in metabolic regulation, an…
Understanding the precise role of GHRH (a hormone that stimulates GH release) in acromegaly is crucial for developing more targeted therapies. If endogenous GHRH significantly contributes to GH hypersecretion, then GH…
Understanding how growth hormone and growth hormone-releasing hormone impact GH secretion and glucose metabolism in HIV-infected patients is profoundly important for managing HIV lipodystrophy and its associated metab…
If the GHRH + Arginine test proves to have high specificity and sensitivity comparable to the ITT, it could represent a significant advancement in diagnosing AGHD. The ITT carries inherent risks due to induced hypogly…
This Phase 1 study is crucial for establishing the foundational safety and preliminary efficacy signals for VRS-317, a potential long-acting treatment for Growth Hormone Deficiency. If successful in maintaining IGF-I …
The successful development of an oral growth hormone secretagogue like AEZS-130 for diagnostic purposes would represent a significant advancement in the management of Adult Growth Hormone Deficiency (AGHD). Such a tes…
The potential of TH9507 to selectively reduce visceral adipose tissue (VAT) in HIV patients with lipodystrophy is highly significant, as this fat accumulation is strongly linked to serious metabolic complications like…
The potential for an oral GH secretagogue like MK-677 to restore youthful GH and IGF-I levels in older adults holds significant promise for combating age-related decline. If successful, this intervention could improve…
The ability to accurately predict cardiovascular mortality in Type 2 Diabetes Mellitus patients with Coronary Artery Disease is paramount for enhancing patient care and improving long-term outcomes. Positive findings …
MOTS-c is a novel mitochondrial-derived peptide with potential roles in metabolic regulation, including glucose homeostasis. If this Phase 2a study demonstrates significant improvements in insulin sensitivity and a fa…
Understanding the optimal pre-procedural management for patients on GLP-1RAs like semaglutide is critical for patient safety and procedural efficacy during endoscopy. If a one-week discontinuation significantly reduce…
This research could fundamentally change our understanding of how GLP-1 RAs exert their metabolic benefits, extending beyond peripheral tissues to direct brain mechanisms. By clarifying the role of semaglutide in enha…
This pilot study is significant because it explores a novel adjunctive therapeutic strategy for Crohn's disease by targeting metabolic health and weight. If successful, it could demonstrate that GIP/GLP-1 receptor ago…
This Phase II IMPACT-ADT trial is profoundly important as it directly addresses a major unmet need in prostate cancer survivorship, aiming to mitigate the severe cardiometabolic side effects of Androgen Deprivation Th…
Understanding the precise mechanisms by which Tirzepatide impacts pancreatic alpha and beta cell function and insulin sensitivity is critically important. This mechanistic insight can refine our understanding of optim…
Understanding the extrapancreatic effects of GIP and GLP-1 is crucial for optimizing current and developing future treatments for type 2 diabetes and obesity. This research will provide critical insights into why comb…
This research is crucial because it addresses a significant unmet need for effective treatments targeting adiposopathy in a vulnerable population with CKD and Type 2 Diabetes. Understanding how GLP-1RAs impact fat dis…
If these anticipated findings are confirmed, this study could redefine the therapeutic approach to obesity and its metabolic complications, moving beyond mere weight loss to direct reversal of underlying metabolic dys…
The successful integration of tirzepatide with automated insulin delivery could represent a paradigm shift in Type 1 Diabetes management, offering a novel strategy to improve glucose control beyond current capabilitie…
This planned study is significant because it aims to explore a novel therapeutic avenue for a highly complex patient population: individuals with obesity and chronic kidney failure. If Tirzepatide demonstrates a favor…
This Phase 3 trial is highly significant as it directly compares Tirzepatide, a novel dual GIP/GLP-1 receptor agonist, against a standard rapid-acting insulin, insulin lispro (U100), in a challenging patient populatio…
If successful, this trial could represent a significant advancement for patients with Type 2 Diabetes and renal impairment, a group with limited treatment options and high unmet medical need. Retatrutide could offer a…
Retatrutide is a novel triple agonist targeting GLP-1, GIP, and glucagon receptors, showing promise in weight loss and glucose control in earlier studies. If this Phase 1 trial demonstrates a significant positive impa…
Tempeh represents a promising functional food for the prevention and management of Type 2 Diabetes Mellitus, offering a natural and sustainable dietary intervention. Its rich profile of bioactive compounds, enhanced b…