484 studies on Insulin curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This research highlights the potential of Mulberry Twig Alkaloids as a novel adjunctive therapy to insulin for managing Type 2 Diabetes. By significantly reducing blood glucose variability, this combination could lead…
This review underscores the critical role of adjunct therapies in optimizing metabolic health beyond insulin in Type 1 Diabetes. The findings suggest that these medications could significantly improve patient outcomes…
This study highlights the potential of innovative educational approaches to significantly improve patient outcomes in chronic disease management. By making learning engaging and interactive, game-based education can e…
These findings highlight the potential for personalized combination therapy to optimize outcomes for Type 2 Diabetes patients using insulin pumps. Integrating specific oral antidiabetic drugs can lead to better glycem…
This research highlights hUCB-MSCs as a promising therapeutic strategy for mitigating core symptoms of Autism Spectrum Disorder. The identification of the IGF-1/Akt signaling pathway as a key mechanism provides valuab…
This extensive review underscores the significant therapeutic potential of PTP1B inhibitors as a novel class of drugs for Type 2 Diabetes, offering a direct approach to reverse insulin resistance. By targeting PTP1B (…
This research highlights the potential of targeted immunomodulation to protect pancreatic beta cells from autoimmune destruction, a critical step towards preventing or reversing Type 1 Diabetes. By specifically activa…
This study provides compelling evidence that MitoPeptide-X can effectively reverse skeletal muscle mitochondrial dysfunction and improve muscle performance in a preclinical model of metabolic disease. This identifies …
This research uncovers a novel and crucial gut-brain-liver axis where gut-derived ghrelin plays a pivotal role in the systemic regulation of glucose metabolism. Understanding this intricate pathway provides significan…
This study highlights the significant metabolic benefits of a linear fragment of unacylated ghrelin (UAG-LF), particularly its ability to improve insulin sensitivity and reduce hepatic steatosis in an obese model. The…
This research provides critical new insights into ghrelin's direct role in regulating pancreatic islet microcirculation, a process fundamental for maintaining islet health and optimal insulin production. Understanding…
This research uncovers a novel and critical brain-gut axis involving ghrelin that directly regulates glycolipid metabolism, providing a deeper understanding of how the brain controls energy homeostasis. The identifica…
This study establishes a robust and efficient theoretical model for ultra-fast calculation of electronic excitation spectra in large systems like proteins and other biomacromolecules. The combination of high accuracy …
This research highlights a novel therapeutic strategy: targeting the ghrelin signaling pathway to enhance the success of islet transplantation. By improving graft survival and function, this approach could significant…
This study provides compelling evidence that targeting ghrelin receptors in the brain offers a novel therapeutic strategy for NAFLD and associated metabolic dysfunctions. By improving hypothalamic insulin resistance, …
This research highlights ghrelin's potential as a therapeutic agent for managing GDM by targeting the underlying mechanism of ER stress. By mitigating ER stress in placental cells and improving glucose metabolism, ghr…
This research highlights ghrelin as a potential therapeutic agent for combating pancreatic β-cell dysfunction and apoptosis, which are central to the progression of type 2 diabetes. By targeting ER stress and the IRE1…
This research highlights the significant potential of GHRP-6 as a functional feed additive in aquaculture, offering a novel strategy to enhance both growth performance and disease resistance in farmed fish. The abilit…
This research suggests that the GHRP-2 test is a highly effective and significantly safer alternative to the ITT for diagnosing GH deficiency in patients with hypopituitarism. Its superior safety profile, particularly…
These findings are profoundly important for understanding the considerable variability observed in responses to GH secretagogue therapies, especially within an aging population that increasingly faces obesity and hypo…
This study provides compelling evidence that the Growth Hormone-Releasing Peptide-2 (GHRP-2) test is a safe and effective alternative to the Insulin Tolerance Test (ITT) for assessing pituitary-adrenal responsiveness.…
This research provides compelling evidence that GHRP-2 can directly stimulate ACTH release from the pituitary gland, even when the hypothalamus is impaired. This direct action on the pituitary could make GHRP-2 a valu…
This research highlights the significant potential of GH-Releasing Peptide-2 (GHRP-2) as a safe, rapid, and reliable diagnostic tool for Growth Hormone Deficiency (GHD) in children. Given that the traditional Insulin …
This study delivers a significantly enhanced and highly reliable analytical tool that will empower anti-doping laboratories globally. The substantial improvements in sensitivity and specificity will strengthen the abi…
This study provides crucial preclinical evidence that GHRP-2 can effectively overcome established negative feedback to restore physiological pulsatile growth hormone secretion, rather than simply inducing a general in…
This research provides compelling evidence that the GHRP-2 test and, to a lesser extent, the arginine test, are safer and highly effective alternatives to the high-risk ITT for diagnosing adult GH deficiency. The redu…
This research highlights the potential for a less invasive and more convenient diagnostic approach for Adult Growth Hormone Deficiency. The strong discriminative power of urinary GH and IGF-SDS could significantly red…
This study provides compelling evidence that the combination of GHRP-2 and Cysteamine can synergistically enhance growth performance and muscle development in yaks with growth retardation. This could have significant …
This research suggests that the GHRP-2 test could offer a valuable, less invasive, and potentially safer alternative to current diagnostic methods for secondary adrenal failure, such as the insulin tolerance test, whi…
The study revealed that the GHRP2 test consistently induced a robust increase in both ACTH and cortisol levels, mirroring the physiological stress response. Peak cortisol concentrations following GHRP2 administration …
This research highlights RECK as a novel and potentially significant regulator within the GH/IGF-1 axis, offering a deeper understanding of growth and metabolic control. Identifying RECK's role could open new avenues …
This review underscores the critical role of endocrine imbalances in the pathophysiology of cachexia and highlights the therapeutic potential of steroid pharmacotherapy. By systematically evaluating the evidence, it p…
This research highlights the critical protective role of GHRH and the downstream GH/IGF-I axis in mitigating acute liver injury caused by acetaminophen. The findings suggest that maintaining or enhancing GHRH signalin…
These findings strongly suggest that GHRH antagonists could be a potent new therapeutic strategy for advanced prostate cancer by simultaneously inhibiting tumor growth and its ability to spread. The observed reduction…
This study's findings are significant as they highlight the potential of Growth Hormone Secretagogues (GHS) to effectively elevate IGF-1 levels in hypogonadal men, a population often struggling with associated metabol…
These findings highlight GHRH receptor antagonists as a promising therapeutic strategy for prostate cancer by targeting multiple pathways involved in tumor growth and angiogenesis. The ability to inhibit both cell pro…
This study highlights MR-409 as a promising therapeutic candidate for preventing beta-cell destruction, a critical step in managing Type 1 Diabetes and potentially other forms of diabetes where beta-cell loss is a fac…
This study highlights that MIA-602 represents a novel, targeted therapeutic approach for Acute Myeloid Leukemia, by effectively antagonizing the GHRH pathway. Given the significant unmet need for more effective and le…
This research highlights the potential of a dermofunctional vehicle to therapeutically intervene in skin conditions characterized by inflammation, excessive tissue breakdown, or impaired healing. By downregulating LL-…
MC4R agonists represent a highly promising class of drugs for treating obesity, particularly in patients with genetic forms of the disease where other treatments are ineffective. This review underscores the therapeuti…
This research highlights the melanocortin system as a critical mediator of leptin's therapeutic potential in diabetes, even in states of uncontrolled hyperglycemia. Understanding this pathway could pave the way for no…
These findings underscore the inherent complexity of central insulin signaling and its role in appetite regulation, indicating that the brain's response to insulin is not uniformly predictable. Understanding these inc…
This study provides compelling evidence that targeting the central melanocortin system offers a powerful and chronic mechanism for body mass reduction. The ability to achieve sustained weight loss without the necessit…
This research highlights the CeA as a pivotal hub for integrating metabolic information via AMPK, offering a novel understanding of appetite regulation. The identification of AMPK in the CeA as a sensitive target for …
This study provides compelling evidence that targeting downstream pathways or compensatory mechanisms can effectively mitigate the severe metabolic consequences of 5-HT2CR loss-of-function. The significant improvement…
This research is significant because it definitively establishes the pituitary-dependent mechanism of MK-0677. Understanding this mechanism is crucial for developing and safely utilizing growth hormone secretagogues, …
This finding is significant because it suggests that systemic administration of GH or GH secretagogues may not directly influence GH/IGF-1 signaling within the brain, at least not via increased CSF concentrations. Thi…