484 studies on Insulin curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This research highlights that MK-677 can significantly modulate lipoprotein profiles in obese individuals, demonstrating its potential metabolic activity beyond just growth hormone stimulation. The observed reductions…
This research highlights a novel mechanism by which MK-677 may influence metabolic pathways, specifically by altering the tightly regulated relationship between leptin and body fat. Understanding this discrepancy is c…
This review significantly expanded the understanding of GHS pharmacology, moving beyond their traditional role in GH deficiency. The identification of diverse non-endocrine actions, such as effects on appetite, metabo…
This comprehensive review underscores the broad therapeutic potential of GHS across multiple organ systems and conditions. The observed benefits, from cardioprotection and growth promotion to metabolic improvements an…
The findings suggest that GHS represent a promising therapeutic strategy for combating age-related decline in GH and IGF-1, potentially improving body composition and overall vitality in older adults. By stimulating e…
This review underscores the critical role of the GH/IGF-1 axis in maintaining bone health and highlights the therapeutic potential of both GH and GHSs for bone disorders. The development of GHSs, which stimulate the b…
This comprehensive review highlights ghrelin's multifaceted nature, demonstrating it is far more than just a GH secretagogue. Understanding ghrelin's broad actions opens new avenues for therapeutic development and dru…
The administration of MK-677 led to significant and sustained increases in overall growth hormone (GH) secretion. Specifically, the study observed pronounced elevations in both the 22 kDa and 20 kDa GH isoforms, which…
This study provides compelling evidence that MK-0677, an oral growth hormone secretagogue, can significantly enhance recovery outcomes in elderly patients following hip fracture surgery. The observed improvements in l…
These robust findings underscore the significant therapeutic potential of ghrelin receptor agonists as a multifaceted strategy for intervening in and potentially reversing various aspects of age-related decline. The o…
This synthesis highlights the GH/IGF-I axis as a critical endocrine regulator in Alzheimer's disease, offering a novel perspective on its pathogenesis. Understanding this intricate relationship could pave the way for …
This research strongly suggests that targeting the GH/IGF-1 axis could be a powerful strategy to combat age-related cardiovascular decline and improve vascular health. By restoring endothelial progenitor cell (EPC) fu…
This review underscores the critical need for more robust, evidence-based interventions to address somatopause and its associated age-related conditions. The findings highlight that current GH therapy, despite its pop…
This research highlights a crucial, previously underappreciated, pathway through which thyroid hormone influences metabolic health, specifically by modulating ghrelin secretion. The finding that thyroid hormone can su…
This study provides compelling evidence that MK-0677, an oral ghrelin receptor agonist, can effectively increase IGF-1 levels in hemodialysis patients. This is a critical step towards addressing the IGF-1 deficiency o…
This comprehensive review underscores the therapeutic promise of GHS for conditions characterized by GH deficiency or age-related decline, such as sarcopenia and frailty, by effectively stimulating endogenous GH relea…
This research provides crucial data on the metabolic fate and elimination profile of MK-0677 in horses, which is vital for anti-doping efforts. The identification of long-lived urinary metabolites significantly extend…
This case report provides crucial, albeit preliminary, human data on the combined effects of LGD-4033 and MK-677, highlighting their potent impact on body composition and endocrine function. The observed anabolic effe…
This research highlights the potential of Epithalon as a therapeutic agent to combat age-related metabolic decline and improve pancreatic health. Given that impaired glucose tolerance is a precursor to conditions like…
This research highlights the potential of pineal peptides as a therapeutic strategy to combat age-related endocrine decline, particularly in areas affecting sleep, metabolism, and overall vitality. By restoring crucia…
This research highlights the potential of pineal gland peptides as a novel strategy for combating age-related pancreatic decline. The observed geroprotective effect could lead to new therapeutic approaches for conditi…
This study provides compelling evidence that circulating MOTS-c levels are significantly associated with both metabolic health and the severity of liver fibrosis in patients with MAFLD. The consistent inverse relation…
These findings are significant because they identify MOTS-c as a potential biomarker for lower-body muscle strength, independent of aerobic fitness. This specificity could make MOTS-c a valuable tool for assessing mus…
This research strongly positions mitochondrial-derived peptides as a novel and potent class of therapeutic agents for the management of Type 2 Diabetes. Their ability to simultaneously improve insulin sensitivity, red…
This study provides crucial in vitro evidence for the direct regulatory role of MOTS-c on pancreatic islet cells, suggesting its potential as a therapeutic agent for metabolic disorders. By simultaneously improving in…
This study underscores the critical role of mitochondrial MOTS-c (a mitochondrial-derived peptide involved in metabolic regulation) as a key mediator of exercise's beneficial effects on diabetes. The findings suggest …
This comprehensive systematic review and meta-analysis solidifies the critical role of Mitochondrial Derived Peptides (MDPs) in metabolic regulation and disease pathogenesis. The consistent and robust correlations obs…
This research highlights the critical role of genetic predispositions, specifically the MOTS-c K14Q polymorphism, in age-related health decline. Understanding this genetic link could pave the way for personalized medi…
This research highlights MOTS-c as a promising, non-invasive biomarker for the early detection of Diabetic Kidney Disease (DKD) in children with Type 1 Diabetes Mellitus. Identifying DKD earlier could enable more time…
This research significantly advances our understanding of MOTS-c as a potent regulator of muscle development and metabolism, highlighting its potential to improve muscle health across different fiber types. The findin…
This study provides novel insights by identifying reduced MOTS-c levels as a potential characteristic of obstructive sleep apnea patients. Given MOTS-c's established role in metabolic health and cellular resilience, t…
This research is significant because it suggests that repeated heat stress could serve as a non-pharmacological intervention to influence metabolic and muscular health, particularly during periods of muscle disuse or …
This research highlights the critical role of muscle-fat crosstalk in maintaining metabolic health during aging and provides compelling evidence that its decline can be pharmacologically targeted. The findings suggest…
This comprehensive review highlights MOTS-c as a highly promising therapeutic candidate for Type 2 Diabetes Mellitus (T2DM), offering a multi-pronged approach to combat both metabolic dysfunction and severe cardiac co…
This review significantly advances our understanding of mitochondria-derived peptides (MDPs) as critical regulators of hepatic metabolism and potential therapeutic agents. The identification of MDPs like MOTS-c and Hu…
This research highlights MOTS-c as a potential biomarker and therapeutic target for Polycystic Ovary Syndrome (PCOS). The strong association between reduced MOTS-c and mitochondrial dysfunction suggests that restoring…
This study provides compelling evidence that AOD9604, a specific fragment of human GH, can effectively reduce obesity and improve lipid metabolism without the adverse effects on glucose homeostasis typically associate…
This study provides crucial real-world evidence supporting the efficacy and safety of GLP-1 Receptor Agonists for managing Type 2 Diabetes in older adults, a population often underrepresented in initial clinical trial…
This research underscores the chronic nature of obesity and highlights that GLP-1 receptor agonists function as effective long-term management tools rather than curative treatments. The rapid weight regain and metabol…
These findings provide crucial insights into the complex regulatory network within pancreatic islets, highlighting the dynamic and glucose-dependent role of δ cells in modulating α cell function. Understanding how gly…
This case report is crucial as it underscores the importance of careful and gradual insulin management when initiating potent glucose-lowering agents like tirzepatide. While tirzepatide is highly effective for glycemi…
This study provides compelling evidence that Tirzepatide could serve as a valuable adjunct therapy for overweight or obese individuals with Type 1 Diabetes, offering benefits beyond traditional insulin management. The…
Understanding the real-world adverse event profile of Tirzepatide and Semaglutide when used adjunctively in Type 1 Diabetes is critically important for both clinicians and patients. This information can help manage ex…
These findings suggest that tirzepatide could be a transformative treatment for the severe metabolic complications associated with Partial Lipodystrophy, a condition with limited effective therapies. By simultaneously…
This systematic review highlights a novel and potentially impactful therapeutic avenue for patients suffering from Hidradenitis Suppurativa, particularly those with underlying metabolic comorbidities. Repurposing exis…
This dual agonism approach offers a novel and potentially superior therapeutic strategy for advanced Type 2 Diabetes, addressing both the critical aspects of glycemic control and gut health, which are often severely c…
This review highlights a critical gap in our understanding of optimal T2DM management during pregnancy, particularly concerning newer, highly effective antidiabetic agents. The limited evidence for novel therapies mea…