Mulberry Twig Alkaloids Stabilize Blood Sugar in Type 2 Diabetes When Combined with Insulin

Type 2 Diabetes (T2D) is a chronic metabolic disorder characterized by high blood sugar, often managed with insulin therapy. However, achieving stable blood glucose levels and minimizing blood glucose variability remains a significant challenge for many patients, leading to long-term complications like cardiovascular disease and neuropathy. This study specifically investigates how Mulberry Twig Alkaloids, in combination with insulin, impact blood glucose fluctuations in a diabetic model.

The study revealed significant improvements in blood glucose control with the combined therapy. The MTA-only group showed a modest 15% reduction in mean blood glucose compared to control, while insulin monotherapy resulted in a 28% reduction. However, the combination of MTA and insulin led to the most pronounced effects, achieving a 43% reduction in mean blood glucose compared to the control group. Furthermore, the Mean Amplitude of Glycemic Excursions (MAGE), a key indicator of blood glucose variability, was significantly reduced. > The combination therapy significantly reduced blood glucose variability by 43% compared to insulin monotherapy (p<0.001), indicating a powerful synergistic effect. This synergistic effect was also reflected in improved insulin sensitivity, with the combination group showing a 2.1-fold increase in glucose disposal rate compared to insulin alone (p<0.01).