Retatrutide's Impact on Metoprolol Absorption Explored in Healthy Individuals
To Investigate the Effect of Retatrutide (LY3437943) on Metoprolol Pharmacokinetics in Healthy Participants
Background
Retatrutide is a novel triple agonist targeting GLP-1, GIP, and glucagon receptors, currently under investigation for obesity and type 2 diabetes. Metoprolol is a widely used beta-blocker prescribed for conditions like hypertension and angina. Given that Retatrutide can affect gastric emptying, there's a potential for it to alter the absorption and overall pharmacokinetics (PK) of co-administered oral medications. This study specifically aimed to determine if Retatrutide significantly impacts the systemic exposure of Metoprolol in healthy participants.
TitrateLab articles covering Retatrutide
Written by TitrateLab, separately from the study summarized above.
