LAT1-mediated delivery of engineered R13A-MOTS-c attenuates radiation-induced lung injury via Nrf2 activation and mitochondrial protection.
Abstract
This research highlights a novel strategy to enhance the therapeutic delivery of MOTS-c, a peptide with significant protective properties, by improving its cellular permeability. The findings demonstrate that R13A-MOTS-c effectively combats radiation-induced lung injury through a well-defined mechanism involving LAT1-mediated uptake and Nrf2 pathway activation.
TitrateLab articles covering MOTS-c
Written by TitrateLab, separately from the study summarized above.
