Humanin Peptide Restores Mitochondrial Health, Improves Function After Traumatic Brain Injury

Traumatic Brain Injury (TBI) represents a significant global health challenge, leading to severe and often permanent neurological deficits that profoundly impact quality of life. A critical and pervasive component of TBI pathology is widespread mitochondrial dysfunction, which impairs cellular energy production, increases oxidative stress, and exacerbates neuronal damage, contributing to long-term cognitive, motor, and emotional impairments. Despite extensive research into various neuroprotective strategies, effective therapeutic interventions that specifically target and ameliorate post-TBI mitochondrial damage and its enduring consequences remain elusive, highlighting an urgent need for novel approaches.